Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Isl1"”.
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THE ROLE OF TRIGEMINAL ISL1 NEURONS IN FEEDING BEHAVIOUR
… The work in this thesis identified a marker, ISL1, for brain regions that control masticatory muscles (ISL1MesV and ISL1MoV). Analysis of the inputs to ISL1MoV revealed subcortical regulation of masticatory muscles. Chronic silencing of ISL1MoV resulted in mice exhibiting a starvation …
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Identificazione e Validazione di Hotspot di Metilazione del DNA come Biomarcatori per il Melanoma Cutaneo
… DNA methylation hotspots affecting RARB and ISL1 were selected for the validation analyses performed on melanoma cell lines and melanoma FFPE samples. In particular, the expression and methylation levels of these two transcription factors were evaluated in five melanoma cell lines, A375, …
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A Novel Population of Cardiovascular Progenitors Persist in Neonates as Mesendodermal Cells
… have been isolated from the heart itself express ISL1, KDR, and MESP1, and are capable of differentiating into all major cardiac lineages. The earlier developmental stage at which endogenous CPCs reside may be associated with enhanced multipotency and differentiation capacity. A clonal population …
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Characterizing the Immunogenicity of Islet-like Cells derived from HLA-edited Human Pluripotent Stem Cells
… islet-like cells enriched for islet-like (ISL1+) or enterochromaffin-like (ISL1-SLC18A1+) cells. Finally, I leverage these new protocols to study how HLA proteins affect the immunogenicity of human pluripotent stem cell-derived islets. Using human pluripotent stem cells edited to lack …
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Functional Analysis of SOX11 and NF1 in Sensory Neuron Development and Plasticity
… more specifically and completely in DRG (Nf1-Isl1-CKO). In the third part of this thesis, I discuss some unanticipated results due to Cre expression in the gastrointestinal tract. Nf1-Isl1-CKO mice develop gastric epithelium hyperplasia and inflammation with increased proliferation and …
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Zebrafish Cardiac Development Requires a Conserved Secondary Heart Field
… and myocardium. I show that this field expresses Isl1, a transcription factor associated with the SHF in other species. I further show that differentiation, induced by Bmp signaling, occurs in this progenitor population as cells are added to the heart tube. Some molecular pathways required for SHF …
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MULTI-OMICS APPROACHES TO CHARACTERIZE PATIENT-DERIVED SPINAL CORD ORGANOIDS AND ASSESS NOVEL GENES ASSOCIATED WITH C9ORF72-AMYOTROPHIC LATERAL SCLEROSIS
… course quantification of precursors (SOX2 and ISL1), as well as the progressive increase of post-mitotic MNs (TUJ1 and SMI32) supported proper organoids maturation. This outcome highlights SCOs potential as a tool to recapitulate SC features and properties in vitro. Differential expression …
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Transcriptional profile of c-kit positive cardiac stem-progenitor cells (c-kitpos eCSCs) isolated from the four chambers of the adult human heart
… Pitx2, Tbx5, Tbx20, Hrt1, Hrt2, Fgf8, Fgf10, and Isl1 were found at differential levels in c-kitpos CSCs isolated from the four cardiac chambers. Conclusion: This study is the first to show that c-kitpos eCSCs derived from human adult cardiac samples, do not appear to have a ‘chamber-specific’ …
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Molecular mechanisms of floor plate formation and neural patterning in zebrafish
… and the motoneuron-inducing factor Islet-1 (Isl1). I could show that in zebrafish LFP and p3 neuronal cells are located at the same level along the DV axis, but alternate along the anteroposterior (AP) axis. Moreover, these two different cell populations require different levels of HH …
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Regulation of the development and regeneration of the zebrafish posterior lateral line
… in central localized cells labeled with α-Isl1. In yeats2ⁿˡ²⁴ mutant embryos we see truncated migration of the posterior lateral line primordium, but no changes in proliferation. To better characterize the function and effect YEATS2 mutations have on LL development we generated a …
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PRIMING CARDIOVASCULAR STEM CELLS FOR TRANSPLANTATION USING SHORT-TERM HYPOXIA
<p>Conventional medical treatments fail to address the underlying problems associated with the damage inflicted by a coronary event. Thus, the long-term prognosis of patients admitted for heart failure is disheartening, with reported survival rates of 25 percent. Recent advances in stem cell …
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Mechanisms by which variants in the TCF7L2 gene increase the risk of developing Type 2 diabetes
Type 2 diabetes mellitus (T2DM) is a heterogeneous disease with a multifactorial aetiology comprising of genetic and environmental factors. The common variant most highly associated with T2DM known to date is a SNP rs7903146 in the TCF7L2 gene. However, the role TCF7L2 plays in the development of …