Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 40 for “"Ischemic injury"”.
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Investigating the possible cytoprotective effects of melatonin isomer against simulated ischemic injury
… of wine against lethal ischemia/reperfusion injury. Recently, the presence of melatonin isomers has been identified in red wine, but whether or not these isomers confer any physiological properties is unknown. Aim: The aim of our study was to establish a cell culture model of simulated …
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The Cross-Talk Between Neurons and Microglia Through Interleukin-4 After Ischemic Injury
<p>After ischemic stroke, the loss of blood supply to the affected region of the brain leads to a series of pathological events known as ischemic cascades, that include excitotoxicity and microglia/macrophage over-activation resulting in damaging inflammatory responses. Studies from our research …
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Cardioprotective Effect of Onion Extract against Ischemic Injury In vitro and In vivo
… apoptosis is one of the pathological features of ischemic heart desease (IHD) and is associated with thrombosis or other acute alterations of coronary atherosclerotic plaques. The mechanisms of these ischemia/reperfusion injuries have been suggested to involve reactive oxygen species (ROS). Allium …
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KDM4D Overexpression Enhances Cardiac Regeneration and Mitigates Myocardial Damage in Response to Ischemic Injury
… as a means to retain cardiac muscle after injury and prevent the development of heart failure has eluded the field for decades. We recently reported that lysine demethylase KDM4D could partially prevent and reverse cell cycle gene silencing, resulting in modest adult cardiac myocyte …
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The Role of Extracellular Matrix and Matrix-Degrading Proteases in Neonatal Hypoxic-Ischemic Injury
… low birth weight infants that survive hypoxic-ischemic (H-I) insults. Because there is a rising incidence in diseases associated with these events, it is critical to develop effective therapies to treat the various resulting neuropathies. Extracellular matrix constitutes the majority of brain …
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Gene Delivery of Adenoviral-TMBIM6 Vector Protects the Neonatal Brain after Hypoxic-Ischemic Injury
<p>Neonatal hypoxia ischemia (HI) is an injury caused to the immature brain due to reduced cerebral blood flow which is associated with life-long neurological impairments. HI causes oxidative protein folding in the endoplasmic reticulum (ER), which results in ER stress. Generation of reactive …
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Using Oxygen Generating Materials for the Preservation of Skeletal Muscle Function & Viability in a Rodent Acute Ischemic Injury Model
… force and penetration wounds can cause traumatic injury to soft tissue of varying types (i.e. skin, nerve, muscle) resulting in a decrease of tissue function and viability. A large percentage of these types of wounds are sustained to the extremities/limbs, not only in our nation’s combat …
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UNVEILING NOVEL CARDIOPROTECTIVE EFFECTS OF GYY4137, A SLOW-RELEASING HYDROGEN SULFIDE DONOR, AND THEIR RELATIONSHIP TO NEUROHORMONAL MODULATION AND MICRORNA PROFILES DURING MYOCARDIAL ISCHEMIC INJURY.
… and microRNA profiles during myocardial ischemic (MI) injury has not been clearly defined. This present study was designed to investigate the cardioprotective effects of slow-releasing water-soluble H2S donor GYY4137 (GYY) and their relationship to neurohormonal modulation and microRNA …
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Dietary Intake and Bio-activation of Nitrite and Nitrate in Newborn Infants
… of NO bioactivity that can protect against ischemic injury, yet plasma nitrite concentrations fall dramatically at birth and remain markedly lower than in adults for the first few weeks of life. The physiological importance of the diminished nitrate→nitrite→NO axis in infants and its …
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EXERCISE-INDUCED ORGAN PROTECTION IN A MURINE MODEL OF CARDIAC ARREST AND RESUSCITATION
Cardiac arrest causes whole-body ischemic injury and cell death. Successful cardiopulmonary resuscitation paradoxically confounds recovery by increasing the rate of cellular death and tissue damage through global reperfusion injury. Despite decades of basic and clinical research, the prognosis …
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Calciumkanaldichte in humanem ischämischen und reperfundierten, rechtsatrialen Myokardgewebe
… mechanisms contributing to myocardial ischemic injury. Two important calcium handling proteins responsible for the maintenance of an intracellular calcium homeostasis are the sarcolemmal voltage-gated L-type calcium channel (DHPR) and the sarcoplasmic reticulum calcium release channel …
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Ischemic Preconditioning and Hydrodynamic Delivery for the Prevention of Acute Kidney Injury
Acute Kidney Injury (AKI) is a prevalent and significant problem whose primary treatment is supportive care. Ischemic preconditioning is a strategy used to protect organs from ischemic injury via a prior injury. Ischemic preconditioning in the kidneys has been shown to confer protection onto …
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Astrocytic communication and cell death during metabolic depression and oxidative stress
… in the brain, but the astrocytic response to ischemic conditions and the extent to which these cells can recover after an ischemic insult is not well understood. An increasing amount of evidence indicates that astrocytes are more sensitive to ischemic injury than previously thought. Astrocytic …
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Long-Term T Cell Responses in the Ischemic Brain
… and morbidity rates worldwide. Following ischemic injury, blood-brain barrier integrity is disrupted and multiple inflammatory cascades are initiated both in the central nervous system and in the peripheral immune system. These early inflammatory responses result in the recruitment of …
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Long-Term T Cell Responses in the Ischemic Brain
… and morbidity rates worldwide. Following ischemic injury, blood-brain barrier integrity is disrupted and multiple inflammatory cascades are initiated both in the central nervous system and in the peripheral immune system. These early inflammatory responses result in the recruitment of …
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Inflammatory Response Following Hemorrhagic Stroke: The Role of Cytokines
… inflammatory responses that occur following injury may be partially to blame for these poor outcomes. In response to any injury, the immune system releases cytokines to recruit immune cell activation and promote inflammation. But after hemorrhagic stroke, whether aneurysmal subarachnoid …
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Innate Immune Transcription Activator Interferon Regulatory Factor-3 (IRF3) Contributes to Maladaptive Remodeling Post-myocardial Infarction
… remodeling process, which follows the initial ischemic episode of MI, is a major determinant of heart failure. Although several key mechanistic pathways involving cell growth and death have been identified, there is limited knowledge surrounding the role of the innate immune response as a …
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Pre-clinical Targets for Ischemic Brain Injury
… cerebral blood flow which results in ischemia. Injury to the myelinated axons located in white matter is observed in ischemic injuries but is generally underappreciated. Research has shown that there is extensive vesicular glutamate release during ischemia, causing excitotoxic injury to …
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Prenatal Undernutrition, Metyrapone, and the Cerebrovasculature
… determine whether glucocorticoids would increase ischemic vulnerability, an important marker of vascular health. Our results demonstrated that food restriction as well as perturbations to early glucocorticoid exposure are critical to the development of the cerebrovasculature, and that …
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