Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Ischemic brain injury"”.
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Pre-clinical Targets for Ischemic Brain Injury
… cerebral blood flow which results in ischemia. Injury to the myelinated axons located in white matter is observed in ischemic injuries but is generally underappreciated. Research has shown that there is extensive vesicular glutamate release during ischemia, causing excitotoxic injury to …
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Perinatal hypoxic-ischemic brain injury – characterization, mechanisms and treatment
… underlying the spread of perinatal hypoxic-ischemic brain injury, particularly connexin hemichannels, pannexin channels and purinergic signaling, as well as to identify mechanisms of injury that are poorly attenuated by therapeutic hypothermia in order to find suitable additive treatments, …
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Identifikace nových indikací léčiv pomocí analýzy transkriptomu jednotlivých buněk
… new drug candidates for the treatment of ischemic brain injury, utilizing our own single-cell transcriptomic data from a mouse model. In summary, this thesis aims to provide insights into the possibilities of single- cell transcriptomics in computational drug repurposing and to propose …
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NEUROPROTECTIVE THERAPIES CENTRED ON POST-TRANSLATIONAL MODIFICATIONS BY SUMOYLATION
Ischemic stroke poses a massive burden of disease and continues to be a leading cause of morbidity and mortality throughout the world. However, beyond thrombolysis/mechanical thrombectomy we possess few effective therapies that are able to modulate the pathogenesis of evolving ischemic brain …
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Modulation as an Acidosis-Evoked Current by A1 Adenosine Receptors in the CA1 Region of the Mouse Hippocampus
… consequences of reduced blood flow to the brain. Acidosis exacerbates ischemic brain injury by activating non-selective cation currents that induce neuronal damage in a calcium-dependent manner, independent of glutamate receptor activation. Adenosine is released during periods of metabolic …
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Mechanisms of Erythropoietin-induced Neuroprotection in: in-vivo and in-vitro Models of hypoxia Ischema
Hypoxic ischemic brain injury (HIBI) is a common cause of neonatal mortality and morbidity. Approximately 60 % of preterm babies and 2% of full term infants suffer from asphyxia. Asphyxia related death accounts for approximately 23% of neonatal mortality annually. Many therapeutic interventions …
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Perinatal Nicotine Exposure and Programming of HIE Sensitive Phenotype in Neonatal Rat Brains
… reprogramming of susceptibility to hypoxic ischemic brain injury in the immature brain, focusing on the roles of AT1R and/or AT2R and trying to reveal the underlying epigenetic mechanisms. Therefore, we established two rat models: perinatal nicotine exposure model in time-dated pregnant …
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Evaluation of cerebrospinal fluid biomarkers of endothelial damage and basement membrane degradation as indirect indicators of blood-brain barrier dysfunction in chronic canine hypothyroidism
… studies have shown that there is loss of blood brain barrier (BBB) integrity in these animals. Current research has also shown the development cerebrospinal fluid abnormalities in neurologically normal hypothyroid dogs; a finding that is related to BBB degradation. This derangement may be …
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Pharmacophore-directed retrosynthesis (PDR) and Density functional theory studies applied to the potent ion channel inhibitor waixenicin A : synthetic studies toward a more stable salarin C congener, thia-salarin C, through the lens of PDR.
… potential drug lead for the treatment of hypoxic-ischemic brain injury (HIBI) and a compelling target for synthetic efforts coupled to biological studies. We first performed conformational studies utilizing density functional theory (DFT) to gain insights into possible bioactive conformations of …
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Study of Regulated Cell Death In Two Systems: Pd-1 In Natural Killer Cells and Rip3 In Neurons
… cell death, which critically contributes to ischemic brain injury and was recently shown to occur through necroptosis, a new form of programmed necrosis. Although RIP3 has been proven to be an important mediator of necroptosis, whether acidosis-induced neuronal death requires RIP3 is not …
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Mechanisms of Neonatal Brain Injury in a Rat Pup Hypoxic-Ischemic Model
<p>Perinatal hypoxic-ischemic (HI) brain injury is a major cause of acute morbidity and chronic nemological mortality in infants and children, with a reported incidence of 2- 9 per 1000 births. The pathophyiological mechanisms leading to immature brain damage after HI are complex and relate to the …
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Analysis of Therapeutic Effect after Human Mesenchymal Stem Cell Transplantation in Ischemic Stroke Rat
… as an attractive therapeutic tool for ischemic stroke because of their plasticity and availability. For the understanding of therapeutic effect of MSCs after transplantation in ischemic rats, changes in free fatty acids (FFA) levels and proteins were detected in 4 days after MSC …
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Characterization of neural ion regulation dysfunction during insult and evaluation of micro-opioid receptor activation during simulated ischemia in the pre-botzinger complex
The health and vitality of brain tissue is dependent upon the cells' abilities to maintain ionic homeostasis across their plasma membranes. Even slight alterations in intracellular or extracellular can have a devastating effect on excitability and neural vitality. This thesis investigates several …