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Showing 1 to 14 of 14 for “"Ischemic Stroke (IS)"”.
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Development of intranasal therapeutic nanoparticles for the treatment of neurological disorders
Globally, ischemic stroke is a leading cause of both death and adult disability. Current therapeutics emphasize reperfusion without further mechanisms to reduce infarct volume or promote healing and are most effective within 3 h of symptom onset: a window in which less than 30% of stroke victims …
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Establishment of the white matter stroke model in rats to study oligodendrogenesis
Subcortical ischemic stroke is a common cause of cognitive dysfunction in the elderly. In this stroke, ischemic injuries to the white matter result in demyelination leading to defective neural connection between the cerebral cortex and subcortical structures. Therefore, repair of the ischemic …
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The Cannabinoid-2 Receptor Agonist O-1966 Reverses Postischemic Learning and Memory Deficits Through Anti-Inflammatory Processes
Ischemic stroke is the third leading cause of death and the leading cause of morbidity in the United States. Cognitive deficits, specifically with respect to learning and memory, are a significant contributor to morbidity in stroke patients. Unfortunately, current treatment options must be …
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Effect of sinusoidal extremely low-frequency electromagnetic stimulation on neurons and glia in a transient stroke model
Ischemic stroke is one of the leading causes of death worldwide. Nowadays, treatment options despite their benefits, have limited use. Therefore, the search for new therapeutic strategies is imperative. Previous studies proved sinusoidal extremely low-frequency electromagnetic stimulation (ELF-EMS) …
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Longitudinal tracking of neural vascular recovery post microinfarct using multimodal neural platform
Ischemic stroke is a leading cause of morbidity and mortality worldwide, with hundreds of thousands of cases occurring annually. The disease is caused by the obstruction or reduction of blood flow to part of the brain, typically due to the buildup of cholesterol-containing fatty deposits called …
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The Role of Insulin and Insulin-like Ischemic Stroke and Cognitive Impairment
… play an important role in growth, metabolism and regeneration throughout the entire life span. In contrast, the role of IGF-II in adult life has been unclear. Animal studies have demonstrated that altered brain activity of the insulin/IGF-system is associated with reduced cognitive …
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Nuove acquisizioni in termini di insufficienza mitralica: complicanze tromboemboliche dopo chirurgia della valvola mitrale: incidenza, predittori e implicazioni cliniche
… surgery for mitral regurgitation (MR) the risk of thrombo-embolic complications, particularly ischemic stroke (IS) compared to that in the general population. Background: MR is frequent, occurs mostly in the elderly and guidelines recommend surgery in asymptomatic patients but IS risks are …
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Gelatin nanoparticles for improved neuroprotection of intranasally delivered osteopontin in ischemic stroke
Delivery of therapeutic agents to the brain is significantly hampered by the blood- brain barrier (BBB). Typically, only small, lipophilic molecules can freely enter the brain parenchyma following systemic administration. During the initial development phases, many drug candidates for neurological …
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Deficits in Auditory, Cognitive, and Motor Processing Following Reversible MCAO in Mice: Understanding the Human Stroke Phenotype
<p>Stoke is characterized by a loss or alteration in neurological and/or bodily function resulting from a cerebral vascular accident (interruption of blood flow to the brain). Acute ischemic stroke is the third leading cause of death in the United States, and the leading cause of long-term …
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Hereditary risk factors for stroke in humans - Association studies with emphasis on familial and genotypic factors
Background Stroke is a serious vascular disorder that comprises intracerebral hemorrhages, subarachnoid hemorrhages and ischemic stroke (IS). The etiology of stroke, including hereditary components induced by cellular mechanisms, is therefore a research field of vital importance. The aim of this …
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INVESTIGATION OF GENETIC FACTORS DETERMINING ISCHEMIC STROKE OUTCOME
<p>Cerebrovascular disease (stroke), especially ischemic stroke, is a major cause of death and neurological disability in adults. Because of its clinical heterogeneity, stroke is considered as a multi-factorial and polygenic disorder. Most current genetic studies of ischemic stroke focus on genetic …
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Aging Exacerbates Neutrophil Pathogenicity In Ischemic Stroke
<p>Ischemic stroke is a major cause of disability and mortality worldwide. As most patients cannot receive the currently approved therapies for ischemic stroke, novel treatments are critically needed. Cerebral ischemia causes irreversible tissue damage, referred to as the “tissue core”, which is …
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Mcp-1 Release Modulation Through Interaction of Pulmonary Endothelial Cells and Mesenchymal Stromal Cells
<p><strong>Background:</strong> Ischemic stroke is a leading cause of death and long-term disability</p> <p>around the world. Current treatment options are limited to the administration of</p> <p>tissue plasminogen activator (tPA) and/or endovascular therapy, administered within</p> <p>a limited …
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MAPK and pro-inflammatory mediators in the walls of brain blood vessels following cerebral ischemia
INTRODUCTION Stroke is a serious neurological disease which may lead to death and severe disability [1, 2]. There are two major types of stroke: ischemic and hemorrhagic stroke. Both are associated with disruption of blood flow to a part of the brain with rapid depletion of cellular energy and …