Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 515 for “"Ischemia"”.
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Astrocyte metabolism following focal cerebral ischemia
… of either the response of astrocytes to cerebral ischemia or the extent to which these cells can recover function if blood flow is restored. The main aim of the project was to assess key metabolic properties in astrocytes during early reperfusion following unilateral occlusion of the middle …
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Experimental porcine models of retinal ischemia
Retinal ischaemia resulting from e.g. diabetes, vein thrombosis or arterial occlusion, is one of the major causes of visual impairment and blindness. Although new methods of treatment are being developed, there is still a need for more effective pharmacological forms of treatment. The aim of this …
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INTRA-MITOCHONDRIAL INJURY DURING ISCHEMIA-REPERFUSION
Cardiac injury is increased following ischemia-reperfusion. Mitochondria are the “effector organelles” that are damaged during ischemia (ISC) when there is no blood flow. Resumption of metabolism by damaged mitochondria during reperfusion (REP) results in increased cell injury. Current therapeutic …
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Pharmacological interventions against myocardial ischemia and reperfusion injury
… with an up-regulation of the δ subtype after ischemia and reperfusion. The µ-opioid receptor was not detected. Conclusions: CsA did not reduce myocardial infarct size, whereas the novel enkephalin analogue EP 94 conferred cardioprotection in different porcine models. The κ- and δ-opioid …
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Treatment of Ischemia Reperfusion Injury with RNA Interference
Ischemia reperfusion injury (IRI) occurs during transplantation and causes apoptosis and inflammation. The purpose of this research was to determine the effect of caspase-3, complement 3, and RelB gene silencing in the reduction of IRI using an in vitro model. LLC-PK1 cells were used along with …
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Ribonomic Control During Global Brain Ischemia And Reperfusion
… <p>RIBONOMIC CONTROL DURING GLOBAL BRAIN ISCHEMIA AND REPERFUSION</p> <p>by HAIHUI WANG</p> <p>August 2014</p> <p>Advisor: Donald J. DeGracia, Ph.D.</p> <p>Major: Physiology</p> <p>Degree: Doctor of Philosophy</p> <p>The study presented here used "omic" technology to look at the mechanism …
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Mechanisms of translation arrest following focal brain ischemia
… TRANSLATION ARREST FOLLOWING FOCAL BRAIN</p> <p>ISCHEMIA</p> <p>by</p> <p>MONIQUE K. LEWIS</p> <p>August 2011</p> <p>Advisor: Dr. Donald DeGracia</p> <p>Major: Physiology</p> <p>Degree: Doctor of Philosophy</p> <p>The loss of blood flow to the brain is termed ischemia and the subsequent …
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Novel Strategies in Cardioprotection against Ischemia/Reperfusion Injury
… (MI), where it plays an important role in ischemia-reperfusion (I/R) injury. Considerable progress has been made towards identifying physiological and pharmacological agents that play a key role in myocardial preconditioning against I/R injury and also elucidating the molecular changes …
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Therapeutic Modalities Targeting Neuroinflammation After Neonatal Hypoxia-Ischemia
<p>Hypoxia-ischemia (HI) occurs in 1-6/1000 live full-term births (Shankaran, 2009). Of those affected, 15-20% will die in the postnatal period, and 25% of survivors will be left with long-term neurological disabilities (Gunn, 2000; Vannucci, 1997; Fatemi, 2009). It has become increasingly clear …
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Novel Protective Agents against Cerebral Ischemia/Reperfusion Injury.
… exhibited anti-apoptotic properties on cerebral ischemia injury. HNG reduced infarct volume after ischemia/reperfusion injury with pre-treatment or post-treatment (i.c.v. and i.p.) in a middle cerebral artery occlusion model in mice and decreased neurological deficits induced by ischemia. The …
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Ischemia Impairs Vasodilation in Skeletal Muscle Resistance Artery
… in arterioles is impaired with chronic ischemia. We sought to examine the impact of chronic ischemia and age on skeletal muscle resistance artery function. To examine the impact of chronic ischemia, the femoral artery was resected from young (2-3mo) and adult (6-7mo) mice and the …
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Myocardial ischemia and reperfusion injury, clinical and experimental studies
… of physiologic conditions, simulating ischemia and reperfusion at varying durations. Markers for inflammation increased over time, whereas the markers for ROS production and neutrophil activation were at the maximum level at baseline and during the first day. Biomarkers, showing …
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Flavonoid protection of cardiac cells against ischemia-reperfusion injury
Myocardial ischemia-reperfusion injury occurs following the majority of cardiac events including myocardial stenosis and heart surgeries. As reactive oxygen species are one of the major contributors to ischemia-reperfusion injury, strategies to prevent their effects may be directed towards …
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ACUTE MESENTERIC ISCHEMIA, OCCLUSIVE AND NONOCCLUSIVE CAUSES IN ELDERLY
L'ischemia mesenterica acuta è caratterizzata ancora da un alta mortalità dato che è difficile formulare la diagnosi corretta. Purtroppo non esistono linee guida basate sull evidenza di dati raccolti in studi randomizzati controllati. Il nostro studio, come la maggior parte presenti in …
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