Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 42 for “"Ischaemic Stroke"”.
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Hyperglycaemia, insulin and acute ischaemic stroke
Background: Hyperglycaemia is common in acute stroke and is associated with a poor outcome. Underlying aetiology and mechanism of action is poorly understood. Management remains uncertain. Methods: We undertook a randomised placebo controlled trial to assess the effect of GKI …
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Platelet Receptor Glycoprotein VI in Ischaemic Stroke
… thromboembolism underpins the pathophysiology of ischaemic stroke. At sites of atherothrombotic plaque rupture, it is established that platelet surface receptor glycoprotein (GP) VI-dimer binds to exposed sub-endothelial collagen, initiating the signalling required to cause platelet activation. …
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Characterising the role of substance P in acute ischaemic stroke.
… than 15 million people worldwide will suffer a stroke each year two thirds will die or be left permanently disabled. Accordingly, stroke represents an enormous financial burden on the community, due to the cost of hospitalisation, treatment and rehabilitation of stroke patients. Despite the …
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An assessment of diagnosis and prognostication in cardioembolic transient ischaemic attack and ischaemic stroke
Transient ischaemic attack (TIA) and ischaemic stroke is a heterogeneous disease with more than 150 known causes with different profiles of vascular risk factors and recurrence risk. Cardioembolic events account for approximately a third of incident stroke. The aim of my thesis has been to assess …
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The viral protein R in HIV-associated acute ischaemic stroke: a case-control study
… dysfunction, which is a major determinant of ischaemic stroke risk in HIV-infected individuals. Polymorphisms in HIV-1 viral protein R (Vpr) may alter its potential to promote endothelial dysfunction, by modifying its effects on viral replication, reactivation of latent cells, upregulation of …
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Early outcomes of thrombolysis for acute ischaemic stroke in a South African tertiary care centre
Stroke is an important cause of death and disability in sub-Saharan Africa. Recombinant tissue plasminogen activator (tPA) thrombolysis is effective in treating acute ischaemic stroke, but may not be a viable option in developing countries. This prospective observational study was designed to …
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Quality of current ischaemic stroke care practices in the Cape Metro Health District, South Africa
… to assess the acute and post-acute services for ischaemic stroke patients in the Cape Metro Health District in relation to the South African ischaemic stroke guideline. Part A: Protocol - The protocol outlines the purpose of the study and highlights the importance of conducting this study by …
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Treatment of brain cancer and ischaemic stroke utilising High Intensity Focus Ultrasound (HIFU) guide with MRI
… cancer treatment (thermal mode) and treatment of ischaemic stroke (mechanical mode). These two applications were investigated in vitro and in vivo models. MRI was utilized to monitor the lesions created by HIFU either in thermal or cavitation mode in freshly excised lamb brain tissue in vitro, and …
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Characterisation of clinical and anatomical substrates in risk stratification and management of atrial fibrillation and ischaemic stroke
Atrial fibrillation and ischaemic stroke are dual epidemics in society, both associated with poor clinical outcomes, patient disability and significant healthcare expenditure. The conditions are interrelated with a complex causal association appreciated between atrial fibrillation and stroke …
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Characterisation of Nrf2-signalling and the effects of boosting astrocytic Nrf2 in a mouse model of ischaemic stroke
Stroke is the leading cause of disability for adults and the second leading cause of death worldwide. It is characterised by a sudden weakness or numbness of the face, arm or leg, most often on one side of the body. The most common type of stroke is an ischaemic stroke, the blockage of a cerebral …
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The prevalence of atrial fibrillation in patients with ischaemic stroke in a district hospital in the Western Cape
… Atrial fibrillation accounts for 15% of all strokes and a 25% of patients with AF-related stroke have this arrhythmia diagnosed at the time of the stroke. Objectives This study sets out to determine the prevalence of atrial fibrillation in patients with ischaemic stroke, as confirmed on CT …
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Investigating white matter alterations and secondary neurodegeneration with MRI imaging and pathology in a mouse model of ischaemic stroke
Advances in acute ischaemic stroke treatment have increased survival rates, yet many individuals experience long-term complications such as post-stroke cognitive impairment and dementia. While the primary infarct is well characterised, the mechanisms driving chronic degenerative changes in remote …
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Role of non-enhanced CT characteristics for differentiating reversible and irreversible brain tissue injury and estimating the tissue fate in acute ischaemic stroke
… or an unknown time of onset following an ischaemic stroke has largely been based on advanced imaging techniques such as CT perfusion and MRI. However, the universal availability of these techniques is limited. Non-enhanced computed tomography (NECT) is the most widely accessible imaging …
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The role of the HIV-1 Tat protein in acute stroke: more than just a transactivator of transcription?
… virus (HIV) are at increased risk of developing ischaemic stroke. The reasons for this are multifactorial, but HIV-associated vasculopathy is a potentially important cause. HIVinduced chronic inflammation may initiate endothelial dysfunction or accelerate vascular injury from other disease …
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A Four-Year Descriptive Analysis of Stroke in a Private Hospital in the Western Cape
Background: Stroke is the second leading cause of death and disability globally, with an estimated 26% increase in stroke deaths between 1990 and 2010. The World Stroke Society estimated that one in six people will suffer a stroke in their lifetime. In 2010, stroke accounted for 5.9 million deaths, …
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Computed tomography (CT) head studies in a district emergency department: a focused study of CT related imaging and analysis of current practice
… (new pathology 40% and existing pathology 18%). Stroke (32%), trauma (30%) and seizures (16%) were the most common indications for imaging with a yield per indication of 54%, 48% and 20% respectively. The most common imaging finding across all categories was an ischaemic stroke. Stroke indicated …
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The role of regulatory T cells in stroke recovery
Background: Acute ischaemic stroke is a major cause of mortality worldwide. Despite the search for new therapies, tissue plasminogen activator remains the only FDA-approved medication. The immune system is involved in all stages of stroke, from risk factors to pathogenesis and tissue repair. The …
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Ionic dysregulation in white matter damage
… supply to ion pumps causes disruption early in stroke progression. Activation of ion channels through voltage or ligand gating contributes greatly to complications such as intracellular calcium overload in many diseases. This thesis investigated the contribution of different mechanisms of ionic …
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The role of mast cells in a mouse model of focal cerebral ischaemia
Treatments for ischaemic stroke are limited and have low efficacy despite many years of promising research uncovering many potential therapeutic targets. As a result, stroke ranks as the third leading cause of death and the leading cause of disability worldwide. Mast cells have been identified as …
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