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Showing 1 to 20 of 40 for “"Ischaemia-Reperfusion"”.
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Mitochondrial Metabolism in Ischaemia Reperfusion Injury
Ischaemia reperfusion (IR) injury is caused by the re-introduction of oxygenated blood flow to tissues after a period of ischaemia. It is an inevitable consequence of organ transplantation, where its severity contributes to reduced levels of graft function and survival. There are no clinically …
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Mitochondrial dysfunction during ischaemia reperfusion injury in models of organ transplantation
… occurring during this surgical procedure, ischaemia reperfusion injury (IRI), is still a major contributor causing poor outcome. Ischaemia arises due to the lack of blood supply, leaving the tissue without oxygen and substrates, which are crucial for energy generation. Upon reperfusion with …
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Investigating complex I dynamics and ROS production in ischaemia-reperfusion injury
Ischaemia-reperfusion (IR) injury is caused paradoxically when the flow of oxygenated blood to an organ is restored after a period of restricted blood supply (ischaemia) in the course of a heart attack, stroke or organ transplantation. Mitochondria play a central role in the pathology of IR injury …
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The role of ischaemia-reperfusion injury and mitochondrial dysfunction in organ transplantation
Summary The role of ischaemia-reperfusion injury and mitochondrial dysfunction in organ transplantation Ischaemia and subsequent reperfusion is inherent to solid organ transplantation and contributes to tissue damage, organ dysfunction, and worse recipient outcome. Demand for organs for …
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Molecular detection and charcaterisation of biologically relevant free radicals during surgical ischaemia-reperfusion
… of ROS. In the vitamin C group after 5 min of reperfusion a significant, sudden increase of diastolic pressure in the heart was noted and reached a maximum of 77 mmHg after 12 min of reperfusion and then gradually decreased to 51 mmHg after 60 min of reperfusion period but was quicker than in …
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The role of platelets and their associated recruitment mechanisms, in intestinal ischaemia reperfusion injury
… in the pathophysiology of intestinal ischaemia-reperfusion (IR) injury. The research described in this thesis investigates the role of the major platelet glycoprotein receptors in recruiting and activating platelets following intestinal IR injury, namely GPVI, GPIb-IX-V and the …
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Reactive oxygen species and mitochondrial metabolism in acute myocardial ischaemia reperfusion injury: measurement and modulation
… intermediate succinate that accumulates during ischaemia. This is a major driver of damage upon reperfusion of ischaemic tissue. ROS are however increasingly understood to not only have negative effects, but also to act as biological signalling molecules that are able to activate protective …
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Complement activation and effector pathways in ischaemia reperfusion injury and at the interface with adaptive immunity
Ischaemia reperfusion injury (IRI) is an important source of morbidity and mortality and contributes to renal transplant failure. Renal IRI is known to be mediated by complement, which causes direct injury to the transplant and stimulates the adaptive immune response against transplant antigens. …
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Evaluation of a novel mitochondria‐targeted anti-oxidant therapy for ischaemia-reperfusion injury in renal transplantation
Ischaemia-reperfusion (IR) injury makes a major contribution to graft damage during kidney transplantation and increases the risks of primary non-function, delayed graft function and rejection. Oxidative damage to mitochondria is a key early event in IR injury. The aim of this project was to …
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Developing an adjunct therapy to mechanical thrombectomy in a murine model of stroke ischaemia reperfusion injury
… stroke as it allows for more rapid and complete reperfusion of the ischaemic tissue compared to recombinant tissue plasminogen activator (rtPA) alone. The advancements in imaging techniques, together with MT, have extended the therapeutic window of reperfusion therapy and have enhanced patient …
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Influence of upper limb ischaemia-reperfusion injury on the regulation of cutaneous blood flow during local thermal hyperaemia
… to investigate the effects of acute upper limb ischaemia- reperfusion (I-R) on neurovascular and endothelial control of the cutaneous micro-circulation in the forearm and finger by evaluating its influence on the magnitude and kinetics of the vasodilatory response to local skin heating. Study 1 …
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Developing methods for measuring mitochondrial redox status and membrane potential in the isolated perfused heart
… have been identified as a key player in cardiac ischaemia-reperfusion injury serving as both a source and target of damage. The energetic status of mitochondria critically determines the progression of ischaemia-reperfusion injury by dictating the thermodynamic likelihood of reverse electron …
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CARDIAC ENERGY METABOLISM IN ISCHAEMIA AND TYPE 1 DIABETES
… reactive oxygen species and tissue necrosis upon reperfusion. In a different paradigm of metabolic disease, the type-1 diabetic heart becomes more dependent upon the oxidation of fatty acids (FAO) for ATP synthesis due to an inability to regulate blood glucose concentration. The work presented in …
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The role of sublethal stress on mitochondria and the development of cardiac preconditioning
… the heart partially resistant to subsequent ischaemia/reperfusion induced cell death.
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Mitochondrial Metabolism Elucidated by Rapid Fractionation from Tissue
… and mitochondrial dysfunction, such as ischaemia-reperfusion injury. A detailed understanding of the metabolic changes in different cellular pools would aid diagnosis and treatment. However, the current methods of mitochondrial isolation are too slow to provide a snapshot of purely …
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Preconditioning and augmented preconditioning via manipulation of metabolic and signalling pathways in the rat heart
… to the heart against subsequent prolonged ischaemia and reperfusion injury. Understanding this survival programme will enable us to augment tissue tolerance against cell death. Ischaemic preconditioning is poorly understood, however, certain metabolic events and activation intracellular …
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Cardioprotective effects of Glucagon-like Peptide 1 (GLP-1) and their mechanisms
… been demonstrated to protect against non-lethal ischaemia reperfusion injury in the left ventricle in humans. It has been suggested from some animal research that this protection may be mediated through the pathway of ischaemic conditioning, of which the opening of the mKATP channel is a key …
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