Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 134 for “"Ischaemia"”.
-
Testicularis ischaemia-reperfusio microcirculatiós vonatkozásai
Az ischaemia során az átrendeződő sejtmetabolizmus, intracelluláris energetikai krízis, az ionpumpák diszfunkciójából keletkező ioneloszlási zavar és a mitokondriumok működési elégtelensége a sejt halálához vezethetnek. A reperfusio során az oxigén ellátottság helyreáll, ami paradox módon további …
-
Mitochondrial Metabolism in Ischaemia Reperfusion Injury
Ischaemia reperfusion (IR) injury is caused by the re-introduction of oxygenated blood flow to tissues after a period of ischaemia. It is an inevitable consequence of organ transplantation, where its severity contributes to reduced levels of graft function and survival. There are no clinically …
-
Upper limb ischaemia : a twelve year experience
Introduction: Upper limb ischaemia (ULI) is a relatively uncommon, but well recognized vascular entity. The sequalae of impaired function or amputation of an arm can be devastating to the individual with loss of independence and / or livelihood. There remains much to be learned that can only be …
-
Barbiturate treatment in experimental transient focal cerebral ischaemia
… attractive situation of transient focal cerebral ischaemia simulating a cerebral vessel occlusion followed by re-vascularization, had not been specifically investigated with barbiturate treatment. Cerebral infarction is progressive and evolves over hours, proceeding from ischaemia and functional …
-
TREM-2 Expression and Regulation in Inflammation and Ischaemia
… by neurons, and this suppression is lost during ischaemia, increasing TREM-2 expression. In conclusion, this study characterised TREM-2 expression in non-myeloid cells and identified novel mediators and signalling pathways that regulate TREM-2 expression, which may be responsible for TREM-2 …
-
CARDIAC ENERGY METABOLISM IN ISCHAEMIA AND TYPE 1 DIABETES
… in greater functional recovery following ischaemia/reperfusion. Supplementation with dietary nitrate ablated this cardioprotective effect, but this highlights the importance of fatty acid oxidation to recovery from ischaemia/reperfusion injury. Ketogenesis was found to occur in the …
-
Acute, Low-Grade Inflammation elevates White Matter Sensitivity to Ischaemia
… interact with co-morbidities such as cerebral ischaemia, are yet to be examined. This thesis evaluated the response of white matter to acute, low-grade inflammation and the downstream effects this had on its sensitivity to ischaemia. <br/><br/>Here, I used isolated ex vivo white matter tracts …
-
Arrhythmia mechanisms in acute ischaemia and chronic infarction in rabbit heart
… consequences of acute regional ischaemia in rabbit heart was established using a combination of a novel snare technique and optical mapping. The purpose of this approach was to discover the mechanistic link between acute coronary infarction and the occurrence of arrhythmias. The …
-
Mitochondrial dysfunction during ischaemia reperfusion injury in models of organ transplantation
… occurring during this surgical procedure, ischaemia reperfusion injury (IRI), is still a major contributor causing poor outcome. Ischaemia arises due to the lack of blood supply, leaving the tissue without oxygen and substrates, which are crucial for energy generation. Upon reperfusion with …
-
Investigating complex I dynamics and ROS production in ischaemia-reperfusion injury
Ischaemia-reperfusion (IR) injury is caused paradoxically when the flow of oxygenated blood to an organ is restored after a period of restricted blood supply (ischaemia) in the course of a heart attack, stroke or organ transplantation. Mitochondria play a central role in the pathology of IR injury …
-
Audit of acute limb ischaemia in a paediatric intensive care unit
Objective:Iatrogenic acute limb ischaemia in paediatric patients is a well-recognised complication of vascular access. This retrospective review of a paediatric intensive care unit identified patients who developed iatrogenic acute limb ischaemia between January 2008 and July 2013. Methods: The …
-
Cellular Effects of Cerebral Ischaemia In Vitro’. Cerebroprotective Actions of GABAmimetic agents
… 80% of all strokes being the result of cerebral ischaemia. There is substantial evidence that during an ischaemic insult extracellular glutamate levels dramatically increase and this increase is strongly implicated in neuronal death. Decreased function of inhibitory mechanisms may also contribute …
-
The role of ischaemia-reperfusion injury and mitochondrial dysfunction in organ transplantation
Summary The role of ischaemia-reperfusion injury and mitochondrial dysfunction in organ transplantation Ischaemia and subsequent reperfusion is inherent to solid organ transplantation and contributes to tissue damage, organ dysfunction, and worse recipient outcome. Demand for organs for …
-
The role of mast cells in a mouse model of focal cerebral ischaemia
… the acute phase of experimental focal cerebral ischaemia, and interact with the brain to potentiate ischaemic pathology by release of a plethora of pro-inflammatory, vasoactive and proteolytic mediators. These mediators could degrade the BBB leading to vasogenic oedema, and may also promote an …
-
Molecular detection and charcaterisation of biologically relevant free radicals during surgical ischaemia-reperfusion
… process. After 30 min of global, now-flow ischaemia and 60min of reperfusion infarct size averaged 33% ± 1 in Control group and 30 % ± 1 in Vitamin C group, respectively, (P<0.05). There is strong evidence that oxygen centered radicals contribute to postischaemic dysfunction after global …
-
The role of platelets and their associated recruitment mechanisms, in intestinal ischaemia reperfusion injury
… in the pathophysiology of intestinal ischaemia-reperfusion (IR) injury. The research described in this thesis investigates the role of the major platelet glycoprotein receptors in recruiting and activating platelets following intestinal IR injury, namely GPVI, GPIb-IX-V and the …
-
Metabolism in myocardial ischaemia and reperfusion with specific reference to the role of glucose
… is known to be protective in moderate low flow ischaemia due to the production of glycolytic ATP. However, it is questioned whether glucose would still be protective in ultra-low flow ischaemia. Firstly, glycolysis is thought to be inhibited, and secondly, deleterious glycolytic metabolites …
Page 1 of 7