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Showing 1 to 20 of 59 for “"Iron uptake"”.
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Mechanistic studies of iron uptake into, and release from, Ferritins
Abstract Iron is the most common and perhaps the most crucial transition metal. It is essential for virtually all of life yet it is also potentially extremely toxic; therefore, how organisms handle iron (iron metabolism) is of critical importance. Ferritins constitute a large family of iron storage …
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Investigation of a novel iron-uptake system and other genomic features in mecC Staphylococcus aureus
… lineages. For microbes and humans alike, iron is an essential cofactor in many biochemical reactions and S. aureus requires iron for colonisation and subsequent pathogenesis. The success of S. aureus is partly attributed to its ability to exploit the host iron pool. It does this through …
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Soil and plant factors associated with iron chlorosis of Kentucky bluegrass
Iron (Fe) chlorosis is a common problem on turfgrasses grown under alkaline soil conditions. The objective of this study was to determine the iron uptake efficiency of different varieties of Kentucky bluegrass. In this study, 25 varieties and 5 blends of Kentucky bluegrass (Poa pratensis L.) were …
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Characterization of the degradation of wild-type and mutant HFE proteins during stress signalling in the endoplasmic reticulum
… the cell membrane. It acts to regulate cellular iron uptake by interacting with the Type 1 transferrin receptor and interfering with its ability to bind iron-loaded transferrin. There is also evidence that HFE regulates systemic iron levels by binding to the Type II transferrin receptor although …
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The development of a new reporter system to study the interaction between FbpA and FbpBC
Bacteria require efficient iron acquisition systems to infect and colonize the mammalian host. Neisseriaceae and Pasteurellaceae have developed an iron uptake system that involves iron removal from host glycoproteins. The human pathogen, Haemophilus influenzae, has a surface receptor complex …
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CHARACTERIZING THE ROLE OF PUTATIVE VIRULENCE GENES ASSOCIATED WITH INFECTION, COLONIZATION AND PERSISTENCE OF SALMONELLA ENTERITIDIS IN CHICKEN USING A BIOLUMINESCENT REPORTER
… during yolk sac infection hinted that Salmonella iron homeostasis may be critical to pathogenesis in a chicken model. The contribution of various iron uptake systems has been investigated comprehensively in murine models with inconsistent data. Lack of information in a chicken model encouraged us …
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Molecular and cellular insights into iron regulation
The iron hormone hepcidin is regarded as the main iron homeostatic regulator in the human body. It is predominantly produced by hepatocytes in response to systemic iron excess. However, since the cellular and molecular mechanisms involved in hepcidin expression are not fully understood, this …
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Mechanisms of Iron Acquisition Employed by Neisseria Gonorrhoeae for Survival within Cervical Epithelial Cells
… has evolved a repertoire of high-affinity iron acquisition systems to facilitate essential iron uptake in the human host. Acquisition of iron requires both the energy-harnessing cytoplasmic membrane protein, TonB, as well as specific outer membrane TonB-dependent transporters (TdTs). The …
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The Impact of Iron Deficiency on Plant-Oomycete Interactions
… adapted to cope with dynamic changes in their environment. Abiotic stresses, such as heat, drought, or nutrient deficiency must be overcome simultaneously with biotic threats such as pathogens and herbivores. Oomycete pathogens represent a significant threat to global food production and natural …
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Iron and reactive oxygen in wheat-pathogen interactions
Iron is an essential component of various proteins and pigments for both plants and pathogenic fungi. However, redox cycling between the ferric and ferrous forms of iron can also catalyse the production of dangerous free radicals and iron homeostasis is therefore tightly regulated. During pathogen …
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Non-precious metal catalysts prepared by chemical functionalization of carbon surfaces.
… attempts to make smaller, more convenient and environmentally friendly sources are being investigated. Hydrogen fuel cells are a way to combine both an effective method of power supply, converting chemical energy into electrical energy directly, and a way to employ clean energy. Fuel cells involve …
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The Role Of Mimosine, A Non-protein Amino Acid In Leucaena Leucocephala Subsp. Glabrata (giant Leucaena)
… of the world. It is highly tolerant to many environmental stresses, including drought, low soil fertility, salinity, acidic and alkaline soils, and disease and pest infestation. The entire plant of giant leucaena contains a non-protein amino acid, called mimosine, which is also toxic to animals. …
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A Mathematical Model of the Iron Regulatory Network in Aspergilus Fumigatus
… as other invasive fungal infections, are poor. Iron has been shown to be essential for Aspergillus fumigatus virulence. Furthermore, mechanisms in the iron regulatory network are believed to be potential drug targets since iron management in fungi is vastly different from that in mammals and …
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Responses to Reactive Oxygen Species in Escherichia Coli: The Roles of Aconitase a and Fur Protein
… regulon that monitors intracellular iron concentrations by monitoring concentrations of the ferrous ion. We observed that sub-micromolar concentrations of H2O2 in vivo can cause E. coli catalase and NADH peroxidase mutants (Hpx -) to lose control of their intracellular iron pools. …
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THE DIVALENT CATION TRANSPORTER NRAMP IN PARASITE PERKINSUS MARINUS: GENOMIC, MOLECULAR, STRUCTURAL, FUNCTIONAL AND EVOLUTIONARY ASPECTS
… great hurdle for oyster population restoration. Iron was shown to be an essential element for P. marinus growth and virulence, but iron uptake pathways have not been elucidated. Natural Resistance-associated Macrophage Protein (Nramp), an iron transporter, was considered to be a potential …
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Regulation of Iron Sequestration Systems in Escherichia Coli and Salmonella Typhimurium (Heme, Outer Membrane)
Regulation of iron uptake systems by iron, growth temperature, and heme was examined. Operon fusions were constructed in which the lactose utilization genes were fused to the promoter of the iron-regulated gene which encodes the colicin I receptor. Regulation by iron was shown to be at the level of …
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Identification and Characterization of a Suppressor Mutation That Relieves the Enzymic and Growth Defects of Sod-Deficient Escherichia Coli
… SOD-deficient strains are somewhat starved for iron, and the iron-binding ability of these dipicolinates caused the Fur (iron uptake) regulon to be derepressed in the suppressed strains. However, a fur mutation only partially relieved the auxotrophies, indicating that Fur derepression assists …
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Transferrin binding protein B structure, function, and export in Neisseria gonorrhoeae
Iron, an essential nutrient for most microorganisms, is sequestered in the host by iron-binding proteins, such as lactoferrin and transferrin. Neisseria gonorrhoeae utilizes transferrin as an iron source and its iron acquisition system is composed of two transferrin binding proteins: TbpA and TbpB. …
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