Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Iron transporters"”.
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Misregulation of Iron Handling Proteins in Excitotoxic Brain Injury
The increased iron has been implicated as a major generator of reactive oxygen species (ROS), which can cause neuronal death in neurodegenerative diseases. The present study was also carried out to elucidate the expression of iron handling proteins such as divalent metal transporter-1 (DMT1) …
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THE DIVALENT CATION TRANSPORTER NRAMP IN PARASITE PERKINSUS MARINUS: GENOMIC, MOLECULAR, STRUCTURAL, FUNCTIONAL AND EVOLUTIONARY ASPECTS
… great hurdle for oyster population restoration. Iron was shown to be an essential element for P. marinus growth and virulence, but iron uptake pathways have not been elucidated. Natural Resistance-associated Macrophage Protein (Nramp), an iron transporter, was considered to be a potential …
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Impact of endosomal recycling inhibitors on drug resistant and immune tolerant breast cancers
… the impact it has on the membrane trafficking of iron transporters, and the potential repurposing of endosomal recycling inhibitors (ERIs) to target these drug-tolerant cells. Additionally, we examined the effects of ERIs on the total protein and surface levels of immune checkpoint proteins. This …
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From yeast to animals: A small molecule restores iron mobilization, absorption and hemoglobinization
… this strategy is no longer viable. Disorders of iron metabolism are the most prevalent genetic diseases worldwide and currently, there are more than 25 different human hereditary diseases associated with loss of iron transporter function and therefore aberrant iron transport, homeostasis and/or …
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Roles for multiple iron acquisition systems in Vibrio cholerae
… is a highly successful human pathogen and environmental organism. To thrive in these diverse environments, it must encode the tools necessary to acquire essential nutrients such as iron. A number of V. cholerae iron acquisition systems have been identified, and altogether are necessary for …
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The effects of quercetin on iron metabolism
… known to be major inhibitors of dietary non-haem iron bioavailability, mainly through their action as iron chelators. In this present study Caco-2 cells were used to investigate the influence of quercetin, the most abundant flavonol in the diet, on non-haem iron bioavailability using 55Fe, and the …
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Hinokitiol restores hemoglobinization and mitigates neurodegeneration in animals by re-establishing iron homeostasis
Iron misdistribution disorder is characterized by iron accumulation and iron deficiency in various sites due to ferroportin (FPN1) dysfunction. Genetic FPN1 deficiency causes Ferroportin disease (FD), which is characterized by iron deposition in liver macrophages and anemia. Aside from …
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Small molecules that imperfectly replicate protein function of missing proteins restore physiology in yeast and human epithelia
… diseases that are caused by missing protein ion transporters, including cystic fibrosis and microcytic anemia. Like many other human diseases caused by missing proteins, these diseases are difficult to treat, and new approaches are needed. Some small molecules can perform ion transporter-like …
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Developmental Regulation of the Expression of Nutrient Transporter and BrushBorder Membrane Hydrolase Genes in the Small Intestine of Piglets
… and dipeptidyl peptidase IV, DPP IV), two sugar transporters (Na+-dependent glucose transporter 1, SGLT1, and facilitated glucose transporter 5, GLUT5), a peptide transporter (H+-dependent peptide transporter 1, PepT1), four amino acid transporters (excitatory amino acid carrier 1, EAAC1, …