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Showing 1 to 20 of 53 for “"Iron homeostasis"”.
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The Role Of Cardiolipin In Iron Homeostasis And Glutathione Metabolism
… in this mutant leads to increased expression of iron uptake genes accompanied by elevated levels of mitochondrial iron and increased sensitivity to iron and hydrogen peroxide. Previous studies have shown that increased mitochondrial iron levels result from perturbations in iron-sulfur (Fe-S) …
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Determining the Molecular Underpinnings of Iron Homeostasis in Human Cells
… is crucial for cellular function and survival. Iron, in particular, is tightly regulated as it serves as an essential cofactor for numerous enzymes but can catalyze the formation of toxic radicals at elevated levels. To maintain the necessary cytoplasmic iron concentration, cells store excess …
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Hinokitiol restores hemoglobinization and mitigates neurodegeneration in animals by re-establishing iron homeostasis
Iron misdistribution disorder is characterized by iron accumulation and iron deficiency in various sites due to ferroportin (FPN1) dysfunction. Genetic FPN1 deficiency causes Ferroportin disease (FD), which is characterized by iron deposition in liver macrophages and anemia. Aside from …
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Effects of blood donation and iron homeostasis on medium and long term cardiometabolic outcomes
… of research, the relevance of blood donation and iron homeostasis on cardiometabolic outcomes remains unclear. Objectives. This thesis aims to reliably characterise the relevance of blood donation and iron homeostasis on cardiometabolic outcomes while overcoming some limitations of previous …
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Elucidation Of The Functional Role Of Pcbp-The Cytosolic Iron Chaperone Protein Family, In Cellular Iron Homeostasis
<p> <i> Biological Role of Ferritin </i> - Iron is essential for life and often utilized as a cofactor in many proteins. In humans, iron accumulation causes cirrhosis, arthritis, cardiomyopathy and diabetes mellitus, and it is associated with increased risk of cancer and heart disease. In contrast, …
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Characterization of the Role of Glutaredoxin 3 and Its Binding Partners In Maintaining Iron Homeostasis In Saccharomyces Cerevisiae
<p>The transcription of iron uptake and storage genes in S. cerevisiae is primarily regulated by the transcription factor Aft1. Nucleocytoplasmic shuttling of Aft1 is dependent upon mitochondrial Fe-S cluster biosynthesis via a signaling pathway that includes the cytosolic monothiol glutaredoxins, …
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Genetic and Biochemical Studies of YqjH and YqjI: Cross-talk between Iron Homeostasis and Nickel Homeostasis in Escherichia Coli
… cellular functions. Cells evolved metal</p> <p>homeostasis systems to control metal acquisition and utilization in response to environmental changes in order to fulfill the cellular metal demand under different situations. Extensive studies have been carried out to elucidate metal homeostasis …
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The Impact of Iron on Lysosomal Function in the Retinal Pigment Epithelium
Iron has an essential role in numerous biological processes, where its multiple oxidation states enable it to facilitate electron transfer reactions. However, this property also makes iron overload dangerous, as iron can catalyze the formation of reaction oxygen species. Iron overload has been …
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Molecular and cellular insights into iron regulation
The iron hormone hepcidin is regarded as the main iron homeostatic regulator in the human body. It is predominantly produced by hepatocytes in response to systemic iron excess. However, since the cellular and molecular mechanisms involved in hepcidin expression are not fully understood, this …
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Iron and reactive oxygen in wheat-pathogen interactions
Iron is an essential component of various proteins and pigments for both plants and pathogenic fungi. However, redox cycling between the ferric and ferrous forms of iron can also catalyse the production of dangerous free radicals and iron homeostasis is therefore tightly regulated. During pathogen …
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Novel insights into the interaction between iron and curcumin and its physiological consequences
Ferrous iron salts are used to prevent and treat iron deficiency and iron deficiency anaemia. However, supplemental iron absorption is limited leading to oxidative stress in the intestinal mucosa and gastrointestinal (GI) symptoms that eventually compromises patient adherence to treatment. Iron …
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The Role of Compartmentalized Metabolism in Cellular Metal Homeostasis
… life, as we know it, is not possible without iron. While the list of iron's vital cellular functions is extensive, iron is also quite cytotoxic. Thus, great pains have been taken, at the gene regulation level, to assure that a cell has sufficient iron to copy its genome and power its …
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V-ATPase regulation of Hypoxia Inducible transcription Factors
… isoforms by altering the intracellular iron pool and preventing HIF-$\alpha$ prolyl hydroxylation. In parallel, I characterised two putative mammalian V-ATPase assembly proteins, TMEM199 and CCDC115, identified by the forward genetic screen and subsequent mass spectrometry analysis. I …
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The Regulation of Cellular Iron Metabolism
Iron is essential for life, but it presents a challenge to our cells because of its ability to drive free radical formation that damages proteins, lipids and DNA. While the consequences of iron excess or deficiency for disease are well described, it has only been recently recognised that …
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Iron-induced Complement Dysregulation in the Retinal Pigment Epithelium: Implications for Age-Related Macular Degeneration
… is complex, but identified elements include iron, complement components, and amyloid protein derivatives. This suggests that iron may be involved in the pathophysiology of AMD. Further support for this hypothesis comes from mice lacking ferroxidases Ceruloplasmin (Cp) and Hephaestin (Heph), …
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A Mathematical Model of the Iron Regulatory Network in Aspergilus Fumigatus
… as other invasive fungal infections, are poor. Iron has been shown to be essential for Aspergillus fumigatus virulence. Furthermore, mechanisms in the iron regulatory network are believed to be potential drug targets since iron management in fungi is vastly different from that in mammals and …
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Heterologous overexpression, purification, and characteristion of the Plasmodium falciparum vacuolar iron transporter, PfVIT
… The efforts made so far identified the iron homeostasis and the transport mechanisms involved in its regulation process, as a weak point of the intraerythrocytic Plasmodium parasite. In fact, many antimalarials already target the parasite’s iron detoxification pathways. However, there is …
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Characterization of Complex Transcriptional Regulation Within the YQJH-YQJI Intergenic Region
<p>Iron is an essential cofactor for many biological processes. Due to the potential toxicity of iron as a result of Fenton chemistry, iron homeostasis in humans and other mammals is tightly controlled; this leaves only minute amounts of free iron available to invading pathogenic bacteria. This …
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