Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 38 for “"Iron Overload"”.
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IRON OVERLOAD AND BIRTH DEFECTS
Large, intravenous doses of iron-dextran are teratogenic in a number of laboratory species (M Phil). To elucidate the mechanism, studies were performed in rats and rabbits to identify possible maternal, placental and foetal sites of action. Maternal toxicity, manifested by bodyweight depression, …
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Molecular responses of iron regulatory proteins to iron overload in human liver
Iron is one of the most abundant metals in nature and a necessary element for life. It is not iron per se but rather its implication in the generation of reactive oxygen species that makes the metal harmful when present in excess as seen in iron overload disorders, such as in hereditary …
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Genetic and environmental modifiers of iron overload disease. Why do only some patients get serious health outcomes?
Type 1 genetic haemochromatosis causes iron overload and is most commonly caused by homozygosity for the HFE C282Y variant and to a far lesser extent other HFE C282Y and H63D genotypes. Haemochromatosis is one of the most common genetic conditions in populations of Northern European ancestry, with …
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The Effect of Iron Overload on the Long-term Toxicological Effects of Fumonisin B1 in Rat Liver
The long-term toxicological effects of hepatic iron overload on the cancer initiating and promoting properties of fumonisin B1 (FB1) were investigated in male Fisher 344 rats. An initial pilot (dose response) study over 15 weeks was performed to determine a level of dietary iron that achieves a …
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The Impact of Iron on Lysosomal Function in the Retinal Pigment Epithelium
Iron has an essential role in numerous biological processes, where its multiple oxidation states enable it to facilitate electron transfer reactions. However, this property also makes iron overload dangerous, as iron can catalyze the formation of reaction oxygen species. Iron overload has been …
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Cerebral Amyloid Angiopathy and Transition Metals in Alzheimer's Disease
… brain metals homeostasis and particularly brain iron overload have been postulated to play a role in Alzheimer's disease, contributing to oxidative stress and neuronal injury; however, the source of this iron is not clear and may be due to metabolic derangement(s), failed iron clearance …
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FBS0701: un nuovo chelante orale nel trattamento del paziente con sovraccarico trasfusionale di ferro
… a clinical need for a well-tolerated and safe iron chelator for the treatment of transfusional iron overload. The objective of this study was to assess the safety, tolerability and dose response of FBS0701, a novel oral iron chelator. Design and Methods This phase 2 study to assess the safety, …
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Iron-induced Complement Dysregulation in the Retinal Pigment Epithelium: Implications for Age-Related Macular Degeneration
… is complex, but identified elements include iron, complement components, and amyloid protein derivatives. This suggests that iron may be involved in the pathophysiology of AMD. Further support for this hypothesis comes from mice lacking ferroxidases Ceruloplasmin (Cp) and Hephaestin (Heph), …
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Interplay of Iron and Hydrogen Sulfide in Pathophysiology of Vascular Damage
Hydrogen sulfide (H₂S) and iron are fundamental regulators of redox biology, exerting opposing influences on oxidative stress and vascular homeostasis, yet their mechanistic interplay remains unresolved. This dissertation addresses this gap through a series of studies spanning molecular, …
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Examining Mechanisms and Functional Significance of Adiponectin Stimulated Autophagy in Cardiometabolic Diseases
… to autophagy. In the first study, the effects of iron overload on autophagy in skeletal muscle were observed. Iron toxicity is associated with reduced circulating adiponectin level and increased the diabetes mellitus incidences. Chronic iron overload altered the autophagy regulatory signaling …
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Examining the Impact of PUFAs and the Role of Autophagy in Iron-Induced Ferroptotic Cell Death
Ferroptosis, an iron-dependent non-apoptotic cell death involves lipid peroxidation and associates with cardiometabolic disease and cancer. I established a model of iron overload in L6 cells and measured cell viability, toxicity and lipid peroxidation. Importantly, in PUFA pre-treated cells, the …
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The effects of quercetin on iron metabolism
… known to be major inhibitors of dietary non-haem iron bioavailability, mainly through their action as iron chelators. In this present study Caco-2 cells were used to investigate the influence of quercetin, the most abundant flavonol in the diet, on non-haem iron bioavailability using 55Fe, and the …
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Divalent Effects on Permeatin and Gating of T-type calcium channels
… the role that calcium channels can play in iron overload condition and in cadmium toxicity. Fe2+ entry through calcium channels has potentially deleterious consequences as this entry is unregulated and in iron overload condition where cells have an impaired iron efflux mechanism, calcium …
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Erythropoietin for the Treatment of Porphyria Cutanea Tarda in End Stage Renal Disease
Porphyria Cutanea Tarda (PCT) is an iron-related disease that results from acquired inhibition of hepatic uroporphyrinogen decarboxylase (UROD), the fifth enzyme in the heme biosynthetic pathway. Clinically, PCT presents with chronic photosensitive vesiculo-bullous skin lesions that are painful and …
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Deciphering the mechanism of Transferrin Receptor mRNA degradation under iron replete conditions
Iron is an essential co-factor required for many biochemical reactions in our body, however iron overload can be detrimental to the cells. Thus, intra-cellular iron concentration is meticulously controlled. For most cells in the body, the transferrin receptor (TFRC-1) is the major means through …
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Development of Stimulus-Responsive Ligands for the Modulation of Copper and Iron Coordination
… of metal-related health concerns, including iron overload, UV skin damage, and microbial infection among many other conditions. To address this concern, chelating agents that change their metal binding characteristics in response to external stimuli have been synthesized and characterized by …
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ATHEROSCLEROSIS AND ENDOTHELIAL DYSFUNCTION IN THALASSEMIA
… cardiovascular risk, endothelial function, and iron/heme parameters. Methods included clinical data, biochemical analysis, T2* MRI for iron overload, and carotid Doppler ultrasounds for plaque detection and intima-media thickness. Inflammatory and endothelial markers were assessed in a subgroup. …
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Molecular and cellular insights into iron regulation
The iron hormone hepcidin is regarded as the main iron homeostatic regulator in the human body. It is predominantly produced by hepatocytes in response to systemic iron excess. However, since the cellular and molecular mechanisms involved in hepcidin expression are not fully understood, this …
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Investigating Inflammatory Pathways in Alcohol-Associated Liver Disease
… and processes. Some of the key factors include iron overload, reactive oxygen species (ROS) production and mitochondrial dysregulation. This project aimed to investigate the role of alcohol and iron in inducing liver damage and toxicity. HepG2 (VL-17A) cells were treated with alcohol (200 mM, …
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