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Conformationally-Controlled Late-Stage Modifications for SAR Studies of the C-3-Glcp Moiety of Ipomoeassin F

Whisenhunt, Lucas2024

<p>The resin glycoside, ipomoeassin F has been shown to be extremely potent against multiple cancer lines (IC50 = 4.2-36 nM). However, the mechanism of action of this potent and complex natural product is still not fully understood. The α,β-unsaturated esters of the glucosyl moiety have been shown …

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