Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Ipl1"”.
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The regulation of chromosome segregation by Aurora kinase, protein phosphatase 1 and nucleolar protein UTp7
The Sli15-Ipl1-Bir1 chromosomal passenger complex is essential for proper kinetochore-microtubule attachment and spindle stability in the budding yeast Saccharomyces cerevisiae. Subcellular localization of this complex during anaphase is regulated by the Cdc14 protein phosphatase, which is kept …
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Histone Post-translational Modification Dysregulation Contributes to Toxicity in Amyotrophic Lateral Sclerosis Proteinopathy Models
… alters histone PTMs in yeast. We observed that Ipl1, the histone modifying enzyme responsible for phosphorylation at serine 10 on histone H3, and Rtt109, the histone modifying enzyme responsible for acetylation at lysine 56 on histone H3, are significantly excluded for the nucleus, while the …
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Regulation of Set1-Mediated Methylation of Dam1
… phosphorylation of adjacent serines by the Ipl1 Aurora kinase. The discovery of a second Set1 substrate raised the question of how Set1 function is regulated at the kinetochore. I hypothesized that transcriptional regulatory factors essential for H3K4 methylation at gene promoters might also …
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Assembly and autoinhibitory mechanisms of the budding yeast kinetochore KMN complex
… sites for the EC pathway kinase Aurora B / Ipl1 reduced the affinity of the -helix for Mtw1c and relieved Mtw1c autoinhibition. These results therefore reveal the structural basis by which the S. cerevisiae KMN complex is assembled and recruited by CENP-CMif2 specifically to kinetochores …