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Showing 1 to 20 of 31 for “"Iontophoresis"”.
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Redox Flow Iontophoresis for Brain Cancer Therapy
… the results of my PhD research on redox flow iontophoresis, a new approach that I have developed based on the continuous flow of a redox mediator solution to facilitate charge transfer in iontophoretic devices. Redox flow iontophoresis addresses long standing issues of iontophoresis …
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Ocular Iontophoresis of Nanocarriers for Sustained Drug Delivery to the Eye
<p>Transscleral iontophoresis has been shown as a viable modality to deliver therapeutic drugs for the treatment of eye diseases. Although several studies have been conducted to examine the utility of iontophoresis for both charged and neutral molecules, the understanding of the mechanisms …
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Topical Formulation For Stimulating Sweat Secretion as an Alternative to Iontophoresis
Sweat test or pilocarpine iontophoresis test is the existing method for diagnosis of cystic fibrosis that is recommended to perform at 48 hours after birth. However, the current method is painful, with several side effects such as full thickness skin burn, skin rash, erythema etc. Therefore, the …
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Sweating After Repeated Intradermal Injections or Iontophoresis of Pilocarpine or Acetyl Beta-Methylcholine
Made available in DSpace on 2014-12-09T23:34:01Z (GMT). No. of bitstreams: 1 6910740.pdf: 3066275 bytes, checksum: 4caa6469732971f10b539d15d2a1475d (MD5) Previous issue date: 1968
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Transdermal and transbuccal delivery of lidocaine and nicotine : combined effects of iontophoresis and chemical enhancers
This study focused on the effects of iontophoresis and chemical enhancers on drug release. The transport of Lidocaine HCl (LHCl) and Nicotine Hydrogen Tartrate (NHT) through the skin and mucosa was evaluated for potential clinical applications. These two potential delivery routes have the advantage …
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Novel approaches for ungual and trans-ungual delivery of drugs
… into the nail apparatus. In second project, iontophoresis technique was investigated to improve the ungual and trans-ungual permeation of itraconazole for the treatment of onychomycosis. In vitro and ex vivo permeation studies were performed following two protocols, a) pulse application of …
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Transdermal Iontophoretic Delivery Of Lipophilic Drugs
Iontophoresis is one of the most widely studied active technique for enhancing transdermal delivery of drugs. However, its ability to enhance the delivery of highly lipophilic compounds is poor due to lack of any charge and poor water solubility of molecules. Propofol, a sedative and anesthetic …
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Development of Microfluidic Platforms for Electric Field-Driven Drug Delivery and Cell Migration
… Transdermal drug delivery systems such as iontophoresis are useful tools for delivering chemotherapeutics for tumor treatment not only because of their non-invasiveness but also due to their lower systematic toxicity compared to other drug delivery systems. While iontophoresis animal models …
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Assessment of the Impact of Loading Pressure on Endothelial Function in Diabetic Foot
… of pressure on the skin blood flow response to iontophoresis of acetylcholine (ACh), an endothelium-dependent vasodilator and sodium nitroprusside (SNP), an endothelium-independent vasodilator, were assessed in a group of subjects with Type 2 diabetes and an age-matched control group of subjects …
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Coordination between presynaptic and postsynaptic properties measured at single terminals in hippocampal cultures
… events and local responses using glutamate iontophoresis at putative single-synaptic sites. I monitored pre-synaptic strength via vesicle staining with FM dyes. I found an inverse correlation between pre-synaptic and post-synaptic strength at individual synapses: Intensity of presynaptic …
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Polymer Electrolytes For lontophoretic Drug Delivery
Iontophoresis is a process in which the transport of ions of soluble salts across skin is facilitated by an externally applied potential difference. This technique is novel in providing an external stimulus to ionic drugs in their passage across a skin. Hence, a positively charged drug may be …
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Chemical and physical methods of enhancing the percutaneous absorption of antimicrobial agents
… and supersaturated systems) or physical (iontophoresis) techniques. The hydrochloride salt of chlorhexidine (CHX), a poorly soluble salt, was used throughout this study. The effect of ionisation on in vitro permeation rate across the excised human epidennis was investigated using …
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Novel Delivery Systems For Iron Replenishment
… of FPP using chemical permeation enhancers, iontophoresis, microneedle pretreatment and combination of these techniques were evaluated and proved to be successful in delivering iron across the skin. When iontophoresis was combined with microneedle pretreatment, adequate iron could be …
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Visualization of neuronal geometry in ventral nerve cord ganglia of Acheta domesticus
… the results obtained when using the axonal iontophoresis method applied to the third through seventh ventral nerve cord ganglia. A segmental ganglion of the thorax or abdomen is usually an oval mass of nerve tissue, continuous with the interganglionic connectives (Fig. A). Two or three …
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The cyclic AMP-activated sodium current in the molluscan neuron: A kinetic analysis of regulation by diffusion, phosphodiesterase and calcium ion
… californica were studied by intracellular iontophoresis of cyclic AMP under voltage clamp condition. The I$\sb{\rm Na,cAMP}$ response to cyclic AMP injection is resistant to protein kinase inhibitors, and is very likely mediated by direct cyclic AMP binding to the channel receptor. The slow …
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Microvascular endothelial function in a multi-ethnic group of apparently healthy South African men and women: Implications for testing and the relationship between insulin resistance and microvascular reactivity
… function using Laser Doppler Imagery (LDI) and iontophoresis of acetylcholine (ACh) and sodium nitroprusside (SNP) in a multi-ethnic, apparently healthy group to determine whether: 1) there are ethnic differences in microvascular endothelial function and 2) whether the association between …
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Development and Characterisation of Solid-State Ion-Selective Electrodes, and their Application to Sweat Analysis for Cystic Fibrosis Diagnosis
… test for CF is the Quantitative Pilocarpine Iontophoresis Test (QPIT) for the sweat electrolytes sodium and chlorideii. In the QPIT, the sweat glands are artificially stimulated, a sweat sample is collected, and the concentrations of sodium and chloride ions determined separately using …
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Treatment of dentine hypersensitivity using desensitising toothpastes
… fluoride trays or solutions in conjunction with iontophoresis; or use oflow-level laser therapy. As desensitising dentifrices are so easy to access, inexpensive and can be used at home rather than requiring one or more visits to the dental surgery, they are the most widely used form oftreatment. …
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Transfer Properties of the Hair Cell-Afferent Fiber Synapse
… recordings, capacitance measurements, and iontophoresis. Glutamate is released from hair cells in response to Ca<sup>2+</sup> influx through L-type Ca<sup>2+</sup> channels and is detected by AMPA receptors in postsynaptic fibers. Gradations in the extent of presynaptic stimulation are …
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