Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Ionotropic glutamate receptor"”.
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The role of ionotropic glutamate receptors in chronic central pain after spinal cord injury
… \r\n In models of peripheral injury, increased ionotropic glutamate receptor mediated activity results in spinal central sensitization. Extracellular single-unit recordings from all three regions of the spinal cord (lumbar enlargement, thoracic cord, and brachial enlargement) were made on both …
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Understanding the activation-deactivation mechanism of glutamate receptor proteins at the single molecule level
Ionotropic glutamate receptor proteins form ion channels at the neuronal membrane and mediate excitatory synaptic neurotransmission in the mammalian central nervous system. These receptor proteins, such as NMDA and AMPA receptors, are structurally diverse and house multiple extracellular and …
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ATGLR3.7 AS NEGATIVE REGULATOR OF ATGLR3.3 MEDIATED STRESS RESPONSES
… on the activity of the cation permeable channel Glutamate Receptor-Like 3.3 (GLR3.3), but the mechanisms regulating this crucial factor remain largely unknown. GLRs are homologous to the animals’ ionotropic glutamate receptor channels (iGluRs), which can form both homo and hetero-tetramer. This …
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Role of Cholesterol 24-Hydroxylase in Hippocampal Long-Term Potentiation
… specific defects in N-methyl-D-aspartate (NMDA) receptor function, a subtype of ionotropic glutamate receptor essential for long-term potentiation. The subunit composition of NMDA receptors located in various functional pools is normal in 24-hydroxylase knockout hippocampus, suggesting that …
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Functional consequences of mutations in GRIN2A and GRIN2B associated with mental disorders
… the GluN2A and GluN2B subunits of the NMDA receptor, a subtype of ionotropic glutamate receptor that displays voltage-dependent block by Mg2+ and a high permeability to Ca2+. These receptors play important roles in synaptogenesis, synaptic transmission and synaptic plasticity, as well as …
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Nucleus accumbens dopamine and investigatory behavior : modulation by the ventral subiculum of the hippocampus through the dopamine cell bodies of the ventral tegmental area
… neurons of the ventral tegmental area (VTA) and glutamate containing neurons from the ventral subiculum (VS) of the hippocampus. VS projections to the NAS have been suggested to influence investigatory behavior, at least in part, by evoking glutamate-mediated transmitter release from NAS …
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Endothelin-1 is over-expressed in Amyotrophic Lateral Sclerosis and induces Motor Neuron cell death
… and reactivity. We found that both ETA and ETB receptors are enriched in astrocytes in MSCs. The ET-1 toxic effect was mimicked by ET-3 (100 nM) and sarafotoxin S6C (10 nM), two selective agonists of endothelin-B receptors, and was not additive with that of ET-3 suggesting the involvement of ETB …
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DESIGN, SYNTHESIS AND CHARACTERIZATION OF ISOXAZOLE CONTAINING GLUTAMATE ANALOGS
Ligands targeting the glutamate binding proteins, both the glutamate receptors and transporters hold a great potential as medicinal agents for a wide variety of neurological disorders. In an attempt to synthesize these ligands, a number of synthetic routes have been explored. Many important …
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DESIGN, SYNTHESIS AND CHARACTERIZATION OF ISOXAZOLE CONTAINING GLUTAMATE ANALOGS
Ligands targeting the glutamate binding proteins, both the glutamate receptors and transporters hold a great potential as medicinal agents for a wide variety of neurological disorders. In an attempt to synthesize these ligands, a number of synthetic routes have been explored. Many important …
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Investigations of The Structure-Function Relationship In Kainate Receptors Using FöRster Resonance Energy Transfer
<p>Kainate receptors belong to the family of ion channels known as the ionotropic glutamate receptors. Ionotropic glutamate receptors mediate the majority of excitatory synaptic transmission, modulate the release of presynaptic glutamate, and facilitate dendrite formation. Kainate receptors are …
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The regulation of neuronal excitability by epilepsy-associated gene Nedd4-2
… including the major subunit (GluA1) of an ionotropic glutamate receptor, alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor, which our lab has identified. AMPA receptors (AMPARs) are the most commonly found receptors in the mammalian nervous system, mediating fast …
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Investigation Of Whether Sedentary And Physically Active Conditions Lead To Altered Gabaergic Signaling In The Rvlm
… response to GABA may be due the arterial baroreceptors buffering the actions of GABA through the contralateral RVLM. Once we inhibit the contralateral RVLM then we are able to see differences. Since the arterial baroreceptor reflex provides tonic GABAergic input to RVLM, we wanted to know if …