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Showing 1 to 20 of 39 for “"Ionophores."”.
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Copper ionophores induce autophagy in melanoma cells.
… in times of stress. In this study, two copper ionophores, disulfiram and thiomaltol, were investigated against melanoma. By using immunocytochemistry, Western Blotting and supravital staining, it was confirmed that both ionophores induce autophagy, and furthermore, drive the process to …
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NMR Studies on Model Membranes. Interaction with Metal Ions, Ionophores and General Anaesthetics
… vesicles with membrane active compounds such as ionophores, anaesthetics, surfactants and metal ions.<br/><br/>In chapter 1 an introduction to the NMR technique and current progress in the field of model and biological membranes was given. In chapter 2 it was shown that pulsed NMR techniqes gave …
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Mechanisms of Ionophore Toxicoses: Laidlomycin Propionate Toxicosis in the Horse and Monensin, Laidlomycin, and Laidlomycin Propionate in Muscle Cultures
… of E-63 rat skeletal muscle cells. Each of these ionophores induced dose-dependent increases in lactate concentrations, decreases in pyruvate concentrations, and decreases in accumulations of NR. Cultures of both myoblasts and myotubes responded similarly, except that myoblasts had greater lactate …
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Effects of feeding lasalocid and monensin upon mineral status of steers, and partial absorption and renal handling of minerals in sheep
… and the effects of dietary K upon the actions of ionophores. Two 84-d grazing trials were conducted with steers fed no ionophore, 200 mg lasalocid, or 150 mg monensin. Monensin tended to increase gain of steers, but lasalocid had no effect. Feeding supplemental lasalocid and monensin altered Ca, …
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Modeling Ionophore Selectivity in the Gas Phase: IR Spectroscopy of Solvated Metal Ion-Crown Ether Complexes
… a variety of biological and naturally-occurring ionophores. Thus, crown ethers have become the prototypical ionophore-model systems in chemistry and biology. Insight gained by studying the interaction of crown ethers with metal ions may lead to the design and development of new ionophores that …
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Structure of valinomycin-K+ complex and cryptate-k+ complex in solution by extended x-ray absorption fine structure
… unknown solution states of K+ complexed with the ionophores cryptate and valinomycin. Ionophores are organic molecules which have a polar oxygen and nitrogen cage in the center of the molecule and a hydrophobic organic exterior. These ionophores are capable of trapping a potassium ion within the …
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Abnormal regulation of T lymphocytes from aged rats contributes to immunosenescence
… with the T cell lectin Con A, the calcium ionophores A23187 and ionomycin and the protein kinase C activator, PMA. Similar to human T lymphocytes, but unlike mouse lymphocytes, rat splenocytes and T lymphocytes proliferate in response to calcium ionophores in the absence of detectable IL 2 …
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Copper as an Antibacterial Agent and Disruptor of Protein Stability
… within the microbes they kill. Molecules called ionophores shuttle Cu into the cell to poison it. However, the antibacterial modes of action behind Cu and small molecule ionophores are not well understood. In this work, we employ a variety of biological, spectrometric, and proteomic techniques to …
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Dietary Methionine and Lysine Utilization by Chicks as Influenced by Coccidial Infection and Drug Therapy
… both healthy and coccidial-infected chicks. The ionophores studied were monensin and narasin, and the dietary factors were L-lysine$\cdot$HCl, L-arginine, DL-methionine, protein level and source as well as dietary electrolyte balance. Digestibility and bioavailability of crystalline …
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Multi-Nuclear NMR Studies of Phospholipid Membranes and their Interaction with Membrane Active Substances
… across lipid vesicles in the presence of the ionophores alamethicin, melittin and nystatin was monitored using the lanthanide probe ion Pr3+. Channel characteristics were found to be dependent upon molecular interactions between the lipid and the individual ionophores. The results were …
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An Investigation of Cytochrome Bd Quinol Oxidases of Vibrio Cholerae, Rhodobacter Sphaeroides, and Salmonella Typhimurium
… and efficient method to screening potential ionophores and antibiotics. Chapter six utilizes the assay to investigate the mechanism of triclosan, a widely used bactericide. It was found that triclosan might disrupt bacteria's growth by directly interrupting the membrane integrity.
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Cell biology of settlement and adhesion processes of biofouling algae
… with a 5-fold greater response to Ca\(^{2+}\)-ionophores than AM-ester Ca\(^{2+}\) indicators. During settlement, zoospores exhibited both localised and diffuse increases in cytosolic calcium implying a role in secretion of the adhesive. Secretion of redox-active substrates was detected using …
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The synthesis and sensing capabilities of new amide, urea and nitrile calix4arenes
… d) the developmet of urea-calix[4]arene ionophores showing potential for improved electrochemical aqueous nitrate sensing and e) a contribution to supramolecular synthesis techniques is made by way of a new semi-preparative liquid chromatographic method for the efficient isolation of pure …
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Development Of Single And Array Electro-Chemical Sensors For Real-Time Trace Metal Analysis In Aqueous Environmental Media
… its application through grafting Cu(II) ionophores onto CFMs. The selectivity was further reinforced via inhibition of other species’ adsorption at surface oxygen groups. This stepwise functionalization approach served as a universal platform for elevating CFMs’ selectivity, while …
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Metal ion complexation, extraction and transport by crown and lariat ether compounds
… electrodes containing the lariat ethers as ionophores were utilized. For dibenzo-16-crown-5 lariat ethers, Na* selectivity over other alkali and alkaline earth metal ions was enhanced by increasing the basicity of an oxygen atom in the side arm and by preorganizing the metal ion binding site …
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Transport phenomena in hydrogel membranes
… of the polymer backbone. The ability of ionophores to selectively modulate the permeation of salts through hydrogel membranes was also examined. The results indicated that a dualsorption model was in operation. Finally, hydrogels were used as membrane overlays on coated wire ion-selective …
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Ion channel modulation during Chlamydia trachomatis development
… When the K+ gradient was perturbed using ionophores, a time-sensitive mid-cycle treatment window enhanced a population of novel sub-compartmentalised ‘vesiculated’ inclusions in the late cycle, which contained bacteria and otherwise retained typical features of intact inclusions. …
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Novel mechanisms of Atg16L1 recruitment in non-canonical autophagy
… and LC3 associated phagocytosis (LAP). Certain ionophores and lysosomotropic drugs, such as monensin, can also activate this process and promote LC3 lipidation to lysosomes. This project focuses on Atg16L1, an essential autophagy protein that directs the membrane site where LC3 is lipidated. …
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Steric and kinetic measurements at well-defined surface sites
… ethers onto the electrode surface to serve as ionophores for aqueous metal ion detection. Binding of metal ions into the crown ether shifts the redox potential of the pyrazine linkage to the carbon electrode, and the concentration of metal ion can be quantified electrochemically. The third …
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