Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 37 for “"Ionic current"”.
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Mechanisms of ionic current changes underlying rhythmic activity recovery after decentralization
… (decentralization). For this purpose, changes in ionic currents during the process of network activity recovery after decentralization were studied. The previously unreported phenomenon of coordinated expression of ionic currents within and between network neurons under normal physiological …
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Ion current modulation in bio-mimetic channel systems
… external manipulations. And the modulation of ionic current is a signal for nanopore sensing. Here, several simulation studies focusing on ion channel conductance modulation and nanopore sensing are presented. Specifically, comprehensive research on a designed bio-mimetic channel can lead to …
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DNA ruler : enhancing nanopore sizing resolution by multiple measurements on the same DNA molecule
… in nanopores is enabled by monitoring the ionic current through the pore: translocation (passage) of a molecule through the pore results in a measurable transient modulation of the ionic current. However, compared to methods such as electrophoresis, nanopores have a limited capacity to …
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Biophysical mechanisms of frequency-dependence and its neuromodulation in neurons in oscillatory networks
… examine how, in one neuron type, interactions of ionic currents, even when expressed at different levels, can produce consistent MPR properties, how MPR properties are modified by neuromodulators and how such modifications may lead to distinct functional effects at different network frequencies. …
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New Tools for Studying Nanoscale Electrochemical Phenomena
… discussed. Chapter 5 moves away from Faradaic current measurements toward ionic current measurements of nanoparticles. Emulsified oil droplets are monitored with ionic current measurements and fluorescence imaging to reveal their interactions at a nanopore. In Chapter 6 a new method for …
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Biomolecular transport at and through two-dimensional materials
… A nanopore sequencer operates by recording the ionic current as a single-stranded DNA molecule is electrophoretically driven through a nanopore; ionic current blockades unique to each nucleotide provide a key to the sequence readout. 2D materials provide the ultimate resolution by isolating one …
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Genomics and epigenomics using 2D nanopores
… through the pore is identified by dips in the current blockage induced by the DNA strand, as well as by peaks in the transverse electronic sheet current across the 2D layer. The positions of the methylation sites can be clearly recognized by the relative positions of the dips in the recorded …
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Engineering the Iontronic Properties of Nanoporous Anodic Alumina and Its Applications
… information transduction system based on ionic transmitters are much more energy efficient and versatile. Synthetic iontronic systems bridge solid-state electronics and biological structures, providing an alternative platform for generating and transmitting signals based on the control and …
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Nanopores for detecting and sensing biological molecules
… and single molecule detection techniques, ionic current blockade and blockade duration are the primary signatures associated with reading and scanning. Although these techniques are good enough for single molecule detection, they are not sophisticated enough to analyze and detect single DNA …
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Simulation and modelling to develop a nanopore-based device for ricin detection
… them to facilitate a corresponding blockage of ionic flow through the pore. Molecular dynamics simulations are an effective method of quantitatively and qualitatively studying key design features and mechanisms of current blockage. This work uses coarse-grained Langevin dynamics simulations to …
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Nanopore Detector Feedback Control Using Cheminformatics Methods Integrated with Labview/Labwindows Tools
… channel it can produce a highly structured ionic current blockade pattern, where the lifetimes at various sub-blockade levels reveal information about the kinetics of the biopolymer. Here we describe integration of LabVIEW/LabWindows automation capabilities with the "in-house" Channel …
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2D materials based nanopore structures as single molecule sensors
… as electrophoresis), thereby modulating the ionic current through the nanopore. The temporary modulation of ionic current due to translocation of the molecule provides useful information about the structure, length, orientation and sequence. This versatile approach permits the label-free, …
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Rational Design of DNA-Based Lipid Membrane Pores
… atomic force microscopy, confocal imaging and ionic current recordings we characterise our DNA nanochannels that mimic their natural protein-based counterparts in form and function. We find that they exhibit voltage-dependent conductance states. Amongst other architectures, we create the …
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Microstructural modeling of lithium battery electrodes
… particles aligned in parallel with the current flow, and also by producing a porosity gradient in the electrode. Using particles aligned parallel to the current flow allowed the elimination of tortuosity from the ion path. Graded electrodes provided superior ion transport near the …
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Proton dynamics in ultrathin GdO𝑥H𝑦 films for magneto-ionics
… circuit components. Metal oxides can conduct ionic current, allowing their properties and those of adjacent materials to be controlled through voltage control of ion transport and electrochemical reactions. This thesis focuses on protonic defects in gadolinium oxide and gadolinium hydroxide …
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Simulation, Fabrication, and Characterisation of Ion Track-Etched Asymmetric Nanopores in Thin Amorphous SiO2 Membranes
… devices. One of the major challenges in current nanopore technology is to combine the high throughput rates that nanopores in ultrathin membranes provide with the highly asymmetric transport properties characteristic of long, conical nanopores. This work investigates conical nanopores in …
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Simulation, Fabrication, and Characterisation of Ion Track-Etched Asymmetric Nanopores in Thin Amorphous SiO2 Membranes
… devices. One of the major challenges in current nanopore technology is to combine the high throughput rates that nanopores in ultrathin membranes provide with the highly asymmetric transport properties characteristic of long, conical nanopores. This work investigates conical nanopores in …
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Modeling Action Potential Propagation During Hypertrophic Cardiomyopathy Through a Three-Dimensional Computational Model
… alter various parameters such as tissue size or ionic current amplitudes. The goal of this thesis is to develop a computational model in MATLAB and to determine if this model can accurately indicate cases of hypertrophic cardiomyopathy. This goal is achieved by combining a three-dimensional …
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Nano-pipette as nanoparticle analyzer and capillary gated ion transistor
… but has nanometer size pores. It was found that ionic current drops when nanoparticles enter the nanopore of a pulled micropipette, producing a clear translocation signal. Pulled borosilicate micropipettes with opening 50 ~ 350 nm were used as the detecting instrument. This method provides a …
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Analysis of ion channels with hidden Markov models : parameter identifiability and the problem of time interval omission
… proved to be an appropriate description for the ionic current through specialised proteins situated in the cell membrane. These ion channels open and close randomly and control the flux of ions into and out of the cell. With the study of the current through individual ion channels it is possible …
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