Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 340 for “"Ion channels"”.
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Role of Ion Channels in Glioblastoma
… treatment. Because of diffused GBM invasion throughout the brain, it is impossible for surgery to completely remove the tumour. Chemotherapeutic adjuvants are used in attempt to eradicate remnant GBM cells. Unfortunately, the standard clinically used drugs have limited therapeutic …
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Evolution of Voltage-gated Ion Channels
<p>Voltage-gated Ion Channels (VICs) form a superfamily of energy-independent membrane transporters that facilitate the transfer of charged sodium, calcium, and potassium ions across the cell membrane (Hodgkin & Huxley 1952). The channels contain a selective ion-conducting pore along with several …
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Targeting Ion Channels to Distal Dendrites
Neurons are divided into functional compartments: the soma houses the DNA and transcriptional machinery, the axons conduct action potentials, presynaptic boutons transmit synaptic signals, and dendrites receive and integrate synaptic information. These functional differences are achieved by …
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Simulation Studies of Biological Ion Channels
Biological ion channels are responsible for, and regulate the communication system in the body. In this thesis I develop, test and apply theoretical models of ion channels, that can relate their structure to their functional properties. Brownian dynamics simulations are introduced, in which the …
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Computer Simulation of Biological Ion Channels
… are developed for the rapid and accurate solution of Poisson's equation in the presence of a dielectric boundary and multiple point charges. These algorithms are then used to perform Brownian dynamics simulations on realistic models of biological ion channels. An iterative method of solution, …
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Simulation Studies of Biological Ion Channels
Biological ion channels are responsible for, and regulate the communication system in the body. In this thesis I develop, test and apply theoretical models of ion channels, that can relate their structure to their functional properties. Brownian dynamics simulations are introduced, in which the …
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Computer Simulation of Biological Ion Channels
… are developed for the rapid and accurate solution of Poisson's equation in the presence of a dielectric boundary and multiple point charges. These algorithms are then used to perform Brownian dynamics simulations on realistic models of biological ion channels. An iterative method of solution, …
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Discrete Stochastic Modeling of Ion Channels
Kernel representations are obtained for the concentration and flux away from equilibrium, where the kernel functions have a probabilistic interpretation. This is done in a discrete space model and also in its diffusion limit. In particular, the kernel representation is given for the flux at a …
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Nanoscale transport simulation of ion channels
Ion channels are part of nature’s solution for regulating biological environments. Every ion channel consists of a chain of amino acids carrying a strong and sharply varying permanent charge, folded in such a way that it creates a nanoscopic aqueous pore spanning the otherwise mostly impermeable …
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Engineering of Light-Gated Artificial Ion Channels
… of this project is the development of artificial ion channels that can be actuated by light and thus controlled efficiently. Our artificial system is composed of two regions: the gate and the body part. The gate part is based on light-responsive azo groups while the body part is formed by …
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Synthetic Ion Channels From Lipophilic Guanosine Derivatives
Synthetic ion channels and pores not only represent models of natural transmembrane ion channels, but also demonstrate their potential applications in the areas of drug delivery, biosensors, antimicrobial agents and other molecular devices. In this thesis, lipophilic guanosine derivatives that …
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Mechanisms for Inactivation in Piezo Ion Channels
… mechanical forces is critical for the detection of environmental stimuli as well as the regulation of internal processes necessary for survival. In vertebrates, the molecular mechanisms of somatosensation has remained an important and unresolved neurobiological question. In the past decade, …
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Understanding Voltage -Gated Ion Channels via Molecular Archeology
… molecular genetic and physiological experimentation have allowed better understanding towards voltage-gated ion channels. The voltage-gated ion channels (VIC) superfamily is one of the oldest groups of membrane transporters. Members of the VIC superfamily are capable of transporting potassium, …
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Computational modeling and simulation of ligand-gated ion channels
The pentameric ligand-gated ion channel (pLGIC) superfamily, from bacteria to the brain, convert chemical signals into electric signals. These proteins are composed of two distinct domains; the extracellular domain (ECD), where the chemical compounds (ligands) bind, and the transmembrane domain …
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