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Showing 1 to 20 of 255 for “"Ion channel"”.
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A Python Library For Ion Channel Modeling
The creation and simulation of ion channel models using continuous-time Markovprocesses is a powerful and well-used tool in the field of electrophysiologyand ion channel research. While several software packages exist for the purposeof ion channel modeling, none are available as a Python library. …
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Function and pharmacology of TRPM3 ion channel
For many ion channels there are few, if any, pharmacological agents, and even fewer showing specificity. In this study, a set of pharmacological tools were developed to investigate TRPM3, a widely expressed transient receptor potential (TRP) channel for which no functional role has yet been …
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FEL theory in the ION channel wiggler
The ion channel laser (ICL) is an ultra-compact version of the free-electron laser (FEL),with the wiggler replaced by an ion channel. Given its small size and the large wiggler field that can be created within a small volume, it has enormous potential for generating high-frequency coherent …
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Ion channel modulation during Chlamydia trachomatis development
… causes sexually transmitted and ophthalmic infections (trachoma) in humans. C. trachomatis resides within a specialised membrane-bound replicative compartment termed the inclusion and exhibits a biphasic lifecycle requiring interconversion between two bacterial forms, infectious non-replicative …
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The Diversity of FHF-mediated Ion Channel Regulation
… that bind directly to voltage gated sodium channels (VGSCs), thereby regulating channel activity and consequently neuronal excitability. Mutations in FGF14 cause spinocerebellar ataxia while FGF13 is a candidate for X-linked mental retardation. Since FGF13 and FGF14 are nearly identical …
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Noise Optimization for High-Bandwidth Ion Channel Recordings
… of voltage-clamp current recordings of single ion channels, and concludes that considerable improvements in signal-to-noise ratios can be achieved by minimizing all parasitic capacitances associated with these measurements. A custom integrated amplifier in a 0.13-micron complementary metal …
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Analysis of ion channel stochastic signals for biosensing
… muscle or nerve cells, produce quick depolarizations in response to electrical, mechanical or chemical stimuli: this means that they can change their internal potential through a quick exchange of ions between cytoplasm and the external environment. This can be done thanks to the presence of ion …
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Elucidating TRPA1 Ion Channel Aberrations in Oesophageal Adenocarcinoma.
… landscape of OAC is driven by structural variations and is characterised by high mutation burden. Although recurrent mutations are observed in only few genes, we have identified TRPA1 (Transient Receptor Potential Ankyrin 1) as a novel driver gene in OAC with recurrent mutations in a sequenced …
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CaV1.3 Ion channel expression and hormone therapy in prostate cancer
… with hormone therapy, such as androgen-deprivation therapy (ADT) and/or androgen receptor (AR) antagonists, e.g. Enzalutamide (ENZ). Castrate-resistant disease, where tumours become resistant to hormone therapy, is characterised by limited effective treatments and poor survival outcomes. The …
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Structural and Dynamic Proximal Proteomic Analysis of TRPV2 Ion Channel Activation
… pathway which mediates every vital cellular function through the propagation of localized calcium flux. Transient receptor potential vanilloid type 2 (TRPV2) ion channels are calcium-permeable, tetrameric ion channels with implications in several cellular processes such as immune response, …
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Structural Studies of the Cold and Menthol Sensing Ion Channel TRPM8
… into electrical signals, and elicit pain sensations in higher nerve center inside bodies. The detection of noxious stimuli at the beginning of this sensory circuit is mediated by receptors or ion channels expressed at peripheral nerve endings, which respond to specific chemical, thermal, or …
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Silicon nanopore patch clamp device for measuring single ion channel activity
… neural activity is of high interest with applications in neuron and neural circuit functioning as well as high-throughput ion channel screening for early drug development research. In 1991 Erwin Neher and Bert Sakmann received the Nobel Prize for their invention of the patch clamp, which is based …
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Lipid Chemistry and Mechanical State of the Membrane Modulate Ion Channel Function
… focused on voltage-dependent K<sup>+</sup> (Kv) channels. Kv channels serve many different functions in different cells, but most notably underlie action potentials in electrically excitable cells, such as neurons and muscle (Hodgkin and Huxley, 1952, 1945). Kv channel gating is governed by the …
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Mechanisms of ion channel activation in primary cultured and clonal cell lines
… (-80 to +100 mV). At strong depolarisations (> +50 mV) the currents exhibited time-dependent inactivation that followed a monoexponential time course. The currents were anion selective and exhibited a selectivity sequence of SCN- > I > Br- > Cl- > F- > gluconate. Current activation was …
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Glutamate Excitotoxicty Activates a Novel Calcium Permeable Ion Channel in Cultured Hippocampal Neurons
… brain injury and ALS. Excessive stimulation of NMDA subtypes of glutamate receptors leads to protracted intracellular calcium elevations triggering calcium mediated neurotoxic mechanisms culminating in delayed neuronal cell death. In addition, glutamate excitotoxicity induces a NMDA …
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1-D Brownian Dynamics Simulation With Its Application in Study of Ion Channel
The ion permeation through cell membrane facilitated by ion channel system is essentially 1-D diffusion process. With faster computer and more advanced algorithm, this process could be investigated by Brownian Dynamics simulation, which is a more straightforward and accurate method than traditional …
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Luminescence Resonance Energy Transfer Studies of the Shaker Potassium Voltage-Gated Ion Channel
"Members of the superfamily of voltage-gated ion channels are the molecular components underlying electrical excitability in nerves and muscle. Voltage-gated channels allow the selective flow of ions across the hydrophobic lipid bilayer of a cell, opening and closing in response to changes in the …
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Luminescence resonance energy transfer studies of the Shaker K+ voltage-gated ion channel
Submitted by Meng Tao (mengtao2@illinois.edu) on 2012-10-26T23:06:21Z No. of bitstreams: 1 Posson_David.pdf: 7844031 bytes, checksum: 3cee2902577cf067066066ebcaad3557 (MD5)
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