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Showing 1 to 20 of 26 for “"Ion Mobility Spectrometry"”.
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Enhanced Electrospray Ionization for Mass Spectrometry and Ion Mobility Spectrometry
Electrospray ionization (ESI) has become one of the most commonly used ionization techniques for mass spectrometry (MS) and ion mobility spectrometry (IMS), and efforts continue to improve its performance. ESI-MS is most recognized for its wide application to biomacromolecules where high …
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The detection of hydrazine and related materials by ion mobility spectrometry.
A technique known as ion mobility spectrometry (IMS), which has been under development for about thirty years, has been shown to be capable of detecting hydrazines at low concentrations but with interference from ammonia. Ammonia is usually present in hydrazine environments, as a breakdown product …
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Investigations on the Use of Ion Mobility Spectrometry for Clinical Chemistry Applications
… major objective of this research is to examine ion mobility spectrometry as a rapid screening tool for specific application to clinical chemistry research and laboratory use. Methodology was developed for target analytes representing several classes of physiologically active substances, …
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Method Transfer for Gas-Chromatography Ion Mobility Spectrometry from Laboratory to Industrial Instrumentation
European Union and United Kingdom regulations promoting the use of more environmentally friendly industrial processes, such as the use of aqueous formulation rather than organic matrices, has facilitated the development of problematic biocontamination events during manufacturing. The current gold …
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Ion Mobility Spectrometry : Optimization of Parameters in Collision Cross Sections and Trace Detection of Explosives
Ion mobility spectrometry is a powerful technique for the study related to molecule. The work of tow major applications are introduced in this paper. The first application is the optimization of parameters in CCS. The accurate calculation of the collision cross section for multiple molecules is a …
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The application of ion mobility mass spectrometry to molecules of pharmaceutical significance
Ion mobility-mass spectrometry experiments have been conducted to measure the drift-time and calculate collision cross-sections (CCSs) using travelling wave ion mobility spectrometry, and determine the CCS using drift-tube ion mobility spectrometry systems of analytes. The aim of the study was to …
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Calibration, feature extraction and classification of water contaminants using a differential mobility spectrometer
High-Field Asymmetric Waveform Ion Mobility Spectrometry (FAIMS) is a chemical sensor that separates ions in the gaseous phase based on their mobility in high electric fields. A threefold approach was developed for both chemical type classification and concentration classification of water …
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An explosive vapor generator based on capillary gas chromatography
… of explosive vapors for use in the evaluation of commercial explosive vapor detection systems has been developed based on a capillary gas chromatograph. The design of the vapor generator replaces a flame ionization detector on the gas chromatograph with an effluent heater system to provide …
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Detection of contaminants using a MEMS FAIMS sensor
… of contaminants in water is a critical mission, but thorough testing often requires extensive time at a remote facility. A MEMS implementation of a FAIMS (High-Field Asymmetric-Waveform Ion Mobility Spectrometry) sensor has recently been developed, and is capable of promptly analyzing water …
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MCC-IMS data analysis using automated spectra processing and explorative visualisation methods
Ion Mobility Spectrometry (IMS) is a method to characterise chemical substances on the basis of velocity of gas-phase ions in an electrical field. The data resulting from an IMS measurement is a number of spectra sorted by retention time. Each spectrum contains a series of values and each value …
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INSTRUMENTAL ADVANCES IN CAPILLARY ELECTROPHORESIS MASS SPECTROMETRY FOR TRACE-SENSITIVE PROTEOMICS
… in organisms. Capillary electrophoresis mass spectrometry (CE-MS) serves as a powerful analytical tool for proteomics and offers superior resolution and minimal sample consumption, yet its adoption has been limited by historical gaps in instrumental development. This dissertation progresses …
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Native surface mass spectrometry via static liquid extraction and laser ablation sampling for structural characterization of macromolecules in gas phase.
Native Surface Mass Spectrometry is an emerging field in biochemical sciences that aims to combine non-denaturing macromolecular proteomics with structural biology and biophysics to elucidate protein functions. By sampling endogenous proteins from their intact biological matrix, proteins' …
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Investigating structural and stability characteristics of native-like proteins using ion mobility-mass spectrometry (IM-MS) in positive- and negative-ion mode.
Native ion mobility-mass spectrometry (IMS-MS) is widely used to investigate the structure and stability of biologically relevant proteins and protein complexes. The key goal, and arguably biggest attraction, of native IMS-MS is maintaining the noncovalent interactions responsible for stabilizing …
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Intense laser matter interactions for explosives detection and tunable spectral blueshift
This dissertation investigates explosives detection and spectral shifts induced in metal surfaces by ultrafast laser pulses at intensities ranging from 1013 to 1014 W/cm2. These ~100 femtosecond (fs) pulses facilitate non-resonant vaporization of explosives, enabling non-contact sampling and …
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Rapid and Green Volatilomics of Roasted Hazelnuts: Comparative Multiplatform Analysis and Advanced Data Mining
… While Gas Chromatography coupled with Mass Spectrometry (GC-MS) remains the reference technique, reducing analysis time and minimizing the environmental impact of analytical methods are becoming pressing priorities, especially in industrial contexts. The aim of this thesis was to evaluate …
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Counter-flow Ion Mobility Analysis: Design, Instrumentation, and Characterization
The quest to achieve high resolution in ion mobility spectrometry (IMS) has continued to challenge scientist and engineers in the field of separation science. The low resolution presently attainable in IMS has continued to negatively impact its utility and acceptance. Until now, efforts to improve …
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Development of analytical methodology based on chromatographic and mass spectrometric techniques for the characterization and fingerprinting of bioactive compounds of Crocus sativus L.
… mass spectrometric techniques for the determination and fingerprinting of bioactive compounds derived from Crocus sativus L. and also their interaction with biomolecules, with the aim to investigate their role in human health. The main bioactive analyzed compounds were picrocrocin, crocetin and …
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