Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 5 of 5 for “"Ion Channel Gating"”.
-
Computational Studies of the Concealed Gating Pathways and Electrophysiological Function of the Human Cardiac IKs Channel
<p>Following the completion of the human genome, relating protein molecular structure to its physiological function remains a challenge for the next decade and beyond. Protein malfunction underlies many debilitating and life-threatening diseases. A framework relating protein structure-to-function …
-
Swarna Ramaswamy_Thesis
<p>STRUCTURAL INVESTIGATIONS OF LIGAND GATED ION CHANNELS</p> <p>Swarna Ramaswamy, B.S</p> <p>Advisor: Vasanthi Jayaraman, Ph.D.</p> <p>Ion channels form an integral part of membrane proteins. In the nervous system including the central and the peripheral nervous system, ligand gated ion channels …
-
Structural Insights into Ion Selectivity and Calcium Blockage in Cyclic Nucleotide Gated Channels
Cyclic nucleotides-gated (CNG) channels play an essential role in the visual and olfactory sensory systems and are ubiquitously expressed in a variety of neuronal and non neuronal cells. Details of their underlying ion selectivity properties are still not fully understood and a matter of debate in …
-
Isolation of the Cytosolic C-Terminus Segment of Mammalian Kca Channel a Subunit
<p>The last 20 years of research into ion channels has unraveled unexpected features of the BK<sub>ca</sub> channel as a rheostast for cell activity in excitable tissues and homeostatically fine tuning many biological activation processes in the cell. Great attention has been dedicated to the …
-
Acclimatization to High-Altitude, Long-Term Hypoxia Alters BK Channel Structure and Function
… possible mechanisms for the left shift of the BK channel I-V relationship in native basilar artery myocytes from the two LTH groups. These mechanisms included: differential expression of the accessary BK -1 subunit; differential phosphorylation of the BK subunit; and splice variation of the BK …