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Showing 1 to 13 of 13 for “"Inverse electron-demand Diels–Alder"”.
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An Inverse Electron-Demand Diels-Alder Strategy for Mapping RNA Methylation
… and nanopore sequencing. In this work, an inverse electron-demand Diels-Alder (IEDDA) reaction between allyl-modified nucleosides and a dipyridyl tetrazine was developed and characterised. This reaction uniquely generates a sterically bulky double-addition product for all nucleosides …
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Synthetic strategies for control of structure from individual macromolecules to nanoscale materials to networks
… after their selfassembly. Post-micellization inverse electron demand Diels-Alder reactions of norbornenes and tetrazines were used to signal changes in micelle size and stability through the addition of either hydrophilic or hydrophobic tetrazines.
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A Concise, Stereocontrolled Total Synthesis of Rippertenol
… addition to an unsaturated ketone and a demanding intramolecular aldol condensation, are described. An uncommon Lewis Acid-promoted inverse electron demand Diels-Alder reaction and a challenging ring expansion lead to the first laboratory total synthesis of rippertenol. The synthesis was …
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The Development of Novel Platforms for the Imaging of Cancer by Positron Emission Tomography
… promising solution is the use of the inverse electron demand Diels-Alder (IEDDA) reaction between a 1,2,4,5-tetrazine (Tz) and a <em>trans</em>-cyclooctene (TCO) for pretargeting. By separately injecting antibody and radioligand and allowing the two to “click” <em>in vivo</em>, overall …
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EXPLORING THE REACTIVITY AND INTERACTIONS OF A POLY(FLUORENE-CO-TETRAZINE)-CONJUGATED POLYMER WITH SWNTS
… tetrazine-containing polymers that undergo Inverse Electron Demand Diels-Alder (IEDDA) reactions with trans-cyclooctenes are interesting not only for their intrinsic optoelectronic properties, but also their interactions with π-conjugated surfaces. Here, we prepared a series of …
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The Development of Novel Radioimmunoconjugates for the PET Imaging and Radioimmunotherapy of Cancer
… lastly, we report a protocol for harnessing the inverse electron demand Diels-Alder (IEDDA) click reaction for diagnostic and therapeutic pretargeting; an overall introduction to antibodies in nuclear medicine; and a review based on the role of click chemistry and its advances in recent years.</p>
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Developing unstrained alkenes and alkynes for bioorthogonal chemistry
… Among all the bioorthogonal reactions, the inverse electron-demand Diels–Alder reaction (IEDDA) reaction has its advantage of bearing the fastest kinetics. Although the IEDDA reaction drew considerable attention in chemical biology in the last decade, challenges lie in finding the suitable …
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The preparation of heterocycles by [2+2+2] cyclization and inverse electron demand Dels-Alder reactions of arynes with 1,2,4-triazines
… sixteen new annulated pyridazines were prepared. Inverse electron demand Diels-Alder (IEDDA) reactions of arynes and 1,2,4-triazines were also investigated for the generation of isoquinoline core structures. The results showed that only triazines with electron withdrawing groups participated in …
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Tetrazine-Triggered Bioorthogonal Decaging Reactions for Prodrug Activation
… controlled activation of proteins and drugs. The inverse electron-demand Diels-Alder (IEDDA) reaction between tetrazines and strained alkenes exhibits high reaction rates and selectivity and has been widely applied for the decaging of amine prodrugs. Although amines are common in small molecule …
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Studies in Synthesis and Organocatalysis: (i) The Design and Synthesis of Novel Electron Deficient Dienes and their Application in the First Enamine Activated Organocatalytic 1,6-Conjugate Addition. (ii) The Development of a New Organocatalytic Methodology through the Combination of DNA-Based Catalysis and Organocatalysis
… (52% yield, 12 : 1 d.r.) and an organocatalysed inverse electron demand Diels-Alder reaction (DAINV) (76% yield, 3.1 : 1 : 1.5 d.r.). Combining the 1,6-addition and DAINV methodology let to the development of an enamine/iminium ion organocatalytic cascade reaction which delivered a product with 5 …
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Bioorthogonal Tethering of Drug Fragments to Engineered G Protein-Coupled Receptors
… labeling of CCR5 in live cells using inverse electron demand Diels-Alder ligation was more specific and efficient than the strain promoted azide-alkyne cycloaddition reaction assessed. GCE was then employed to site-specifically introduce one of three different reactive ncAAs in CCR5 …
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Wirelessly addressable chemiresistors : carbon nanotube-based chemical sensors and dosimeters
… 1,2,4,5-tetrazines are employed as a model inverse-electron demand Diels-Alder agent for the dosimetric detection of ethylene. Possible device architectures and fabrication strategies are explored, including colorimetric and chemiresistive implementations. A new solid/liquid chemiresistor …
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Structure and Reactivity in Nanostructured Ionic Solvents
… a small number of chemical processes, such as Diels-alder reactions, polymerization reactions, nucleophilic substitution reactions, condensation reactions, and elimination reactions. The results of those investigations highlighted the untapped potential of using structured media to control the …