Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 40 for “"Invasive breast cancer"”.
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Treatment outcomes of young patients with invasive breast cancer treated radically at Groote Schuur Hospital from 2013-2017: A single centre study
Treatment outcomes of young patients with invasive breast cancer treated radically at Groote Schuur Hospital from 2013 to 2017: A single centre study Background: Breast cancer is the leading cause of cancer- related deaths globally, and the commonest cancer in women under 40 years. There is …
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BREAST CANCER PROGRESSION AND METASTASIS: DISCOVERY OF NOVEL GENES AND THEIR FUNCTIONAL STUDY
Breast cancer is one of major public health problem worldwide. However, the underlying molecular mechanism of breast cancer progression and metastasis is not well understood. Ductal carcinoma in situ (DCIS) is a non-invasive form of breast cancer which could progress to or recur as invasive breast …
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Evidence of Human Endogenous Retrovirus K Involvement In Human Cancer
… patient plasma, serum, and tissue samples from invasive breast cancer (N=19), ductal carcinoma</p> <p><em>in situ </em>(N=13), malignant ovarian cancer (N=12), and benign ovarian tumors (N=9), via IRB-approved and informed consent protocols through M.D. Anderson Cancer Center, as well as normal …
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Breast Cancer Specimen Collection, Handling & Adherence to ASCO/CAP Guidelines
<p>Breast Cancer Specimen Collection, Handling & Adherence to ASCO/CAP Guidelines</p> <p><strong>Background</strong></p> <p>Specimens removed from their blood supply begin to degrade immediately. Specimens are placed in formalin to halt the process of degradation. Under or over-exposure of …
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Investigating The Ecology and Evolution of Normal Breast Tissues and Breast Cancer With Single Cell Genomics
<p>There is vast cellular heterogeneity in human breast tissues, with different transcriptional programs in the stromal, epithelial, and immune components, however, it remains unclear how their reprogramming and interplay leads to the progression of invasive phenotypes such as Triple- Negative …
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Folate - Associations with breast cancer depending on intake, metabolism, genetic variation and estrogen receptor status.
Folate is a B-vitamin that may influence cancer development via its role as methyl donor for DNA synthesis and methylation. Plant foods contain many bioactive compounds including folate and fiber. Results from the Malmö Diet and Cancer (MDC) cohort indicate lower breast cancer risk at high fiber …
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Molekulare Genomanalysen des invasiven Mammakarzinoms und Untersuchung des Einflusses chromosomaler Imbalancen auf die Genexpression
… resolutions of cytogenetic aberrations in invasive breast cancer. The most frequent changes found were gains of 1q, 8q, chromosome 20, and losses involving 16q, 19p, 17p and chromosome 22. The chromosomal imbalances correlated neither with extent of tumour growth, grade or differentiation. …
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A study of the relationship of the internal endocrine environment to the p53 network, cyclin D1 and replication licensing proteins in breast cancer
… endocrine environment in patients with primary breast cancer and to study the expression and prognostic association of cyclin D1 and replication licensing proteins (mcm2 and geminin) in invasive breast cancer. Hypothesis The endocrine environment may be critical in the development and efficacy …
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Krūties vėžio magnetinio rezonanso vaizdo tekstūros analizė /
… resonance imaging radiomics in the detection of breast cancer linked to BRCA1 and BRCA2 gene mutations and to identify precise radiomic features that could develop new non-invasive breast cancer diagnostic approaches, oriented at genetics. Methods: A prospective analysis of MRI radiomic features …
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Improving Medicare & Medicaid Reimbursement Framework for Molecular Diagnostics Tests Using Gene Sequencing: A Case Study in Health Economics
<p>Breast cancer is the second leading cause of deaths among women, as about one in eight women in the US will develop invasive breast cancer during their lifetime. After the diagnosis of breast cancer, chemotherapy is the commonly prescribed first line of treatment. In the recent past, research …
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Frequent expression loss of Inter-alpha-trypsin inhibitor heavy chain (ITIH) genes in multiple human solid tumors : a systematic expression analysis
… TNFAIP6 in 13 different human tumor entities (of breast, endometrium, ovary, cervix, stomach, small intestine, colon, rectum, lung, thyroid, prostate, kidney, and pancreas) using cDNA dot blot analysis (Cancer Profiling Array, CPA), semi-quantitative RT-PCR and immunohistochemistry. RESULTS: We …
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Breast cancer cells cooperate during invasion and metastasis
Metastasis continues to be the leading cause of breast cancer-related deaths. Metastasis is a multistep process during which cancer cells leave the primary tumor, invade and seed inside secondary tissues, leading to lethal organ failure. Currently, no efficient method exists for the elimination of …
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EXAMINING BACKGROUND PARENCHYMAL ENHANCEMENT AS A NOVEL BIOMARKER FOR BREAST CANCER RISK IN BLACK WOMEN
Although breast cancer mortality rates have declined over recent decades, it remains the second leading cause of cancer death among women in the United States. Stark racial disparities persist, with Black women more likely than White women to be diagnosed at later stages and with more aggressive …
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A pilot study exploring the acute effects of aerobic exercise and relaxation on fatigue and executive function in breast cancer survivors
More than 250,000 new cases of invasive breast cancer, and roughly 63,000 new cases of in situ breast cancer were estimated to be diagnosed in 2017, within the United States (DeSantis, Ma, Goding Sauer, Newman, & Jemal, 2017). Chronic fatigue occurs at an extremely high rate in women diagnosed with …
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Mammographic density in relation to breast cancer Tumor characteristics, mode of detection, and density assessments
… density reflects the composition of the breast tissue and can be measured by different methods. Mammography has a lower sensitivity in women with dense breasts, and women with dense breasts have a higher incidence of breast cancer than do women with non–dense breasts. Furthermore, there …
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Design and Evaluation of Peptide Lipid-Associated Nucleic Acids (PLANAs) for siRNA and CRISPR/Cas9 Delivery and Protein Silencing
<p>Breast cancer affects 1 in 8 women in the United States. The American Cancer Society has estimated that in 2020 about 276,480 new cases of invasive breast cancer will be diagnosed in women. Cancer research has taken a turn in the last several decades to focus on new approaches to combat the …
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Molekulare Steuerung des Mamma-Karzinom-Verhaltens durch das inflammatorische Zytokin MIF
… molecular link between chronic inflammation and cancer. In the context of the present study we investigated the role of MIF in tumorigenesis of breast cancer. MIF was abundantly expressed in the non-invasive breast cancer cell lines MDA-MB-468 and ZR-75-1, but not in invasive MDA-MB-231 cells, …
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TACTILE AND MULTISPECTRAL BIMODAL IMAGING FOR BREAST CANCER RISK ASSESSMENT
American Cancer Society estimates that in 2021 nearly 300,000 women in the United States will be diagnosed with invasive breast cancer, and about 43,600 women will die from breast cancer. While many have access to health care and cancer screening, women from rural or underdeveloped communities …
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Atp-Citrate Lyase Links Cyclin E to Cellular Metabolism In Breast Cancer
… one-third of tumors from patients with invasive breast cancer and is a powerful independent predictor for survival in women with stage I-III breast cancer. Full-length cyclin E (EL) is post-translationally cleaved into two low-molecular-weight isoforms, LMW-E (T1) and LMW-E (T2). LMW-E …
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