Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 16 of 16 for “"Invasive Fungal infections"”.
-
Developing novel drug combinations for treatment of invasive fungal infections
Several Fungal species have the potential to cause a broad spectrum of diseases in humans, ranging from mild superficial to disseminated invasive infections that involve the bloodstream and vital organs. Invasive fungal infections are severe, life-threatening diseases that result in the deaths of …
-
Toward the Synthesis of CAY-1, an Antifungal Steroidal Saponin
Invasive fungal infections are prevalent and often deadly in immunocompromised patients. There continues to be a pressing need for the development of novel antifungal compounds since there are currently only 13 compounds licensed for the treatment of invasive fungal infections and …
-
A Mathematical Model of the Iron Regulatory Network in Aspergilus Fumigatus
Aspergillus fumigatus is an opportunistic fungal pathogen responsible for invasive aspergillosis in immunocompromised individuals. Current detection and treatment strategies for invasive aspergillosis, as well as other invasive fungal infections, are poor. Iron has been shown to be essential for …
-
Discovery and development of novel antifungal agents for the treatment of Candida auris infections
Fungal infections are one of the leading causes of death in humans, causing infections that range from mild superficial infections to severe, and life-threatening invasive infections that affect the bloodstream and vital organs. Invasive fungal infections have a high mortality rate, leading to …
-
Cryptococcal Meningitis in The Tropics: Defining the Problem and Refining the Management
… Vietnam, I estimated the burden of all the major invasive fungal infections in Vietnam. An actuarial approach to making these estimates was used, and showed that the leading fungal pathogen is likely to be Aspergillus. The CryptoDex trial was stopped early on the basis of an excess of adverse …
-
Synthesis and Antifungal Evaluation of Barbiturate Saponins And Progress Towards Cysteinyl Metal Peptides
<p>Invasive fungal infections are a major threat to immune-compromised patients. There is a critical need to develop new antifungal agents because of increasing resistance to the common antifungal drugs.</p> <p>In the first part of this dissertation, methods for preparation of novel barbiturate …
-
A synthesis enabled understanding of Amphotericin B leading to derivatives with improved therapeutic indices
Systemic fungal infections represent a significant contributor to human morbidity and mortality. To lower the impact of invasive fungal pathogens on the global population, more progress must be made in the areas of diagnostic tests and safe and effective new therapies. Although Amphotericin B (AmB) …
-
Methods to enable the detection of targeted AmphDI glycosyltransferase mutants that transfer GDP-C2’epimycosamine to amphoteronolide
Invasive fungal infections remain a leading cause of morbidity and mortality in the world, accounting for ~1.5 million deaths each year. Currently available treatments have important limitations, and the emergence of pathogen resistance is further weakening the clinical efficacy of most of these …
-
Probing the role of histone acetylation in the evolution of pathogenicity in <i>Candida glabrata</i>
With the advancement of modern medicine, invasive fungal infections are a growing cause of global mortality.<i> Candida glabrata</i> accounts for 25% of fungal infections in UK hospitals, second only to<i> C. albicans</i>. This number is expected to rise given current treatment challenges due to …
-
Targeting Coenzyme A Biosynthesis for Antifungal Development.
… estimated 1.5 million people die each year from invasive fungal infections (IFIs) involving dissemination to the deeper organs via the bloodstream, with estimated healthcare costs of over $7 billion in the U.S. alone. Collectively, several Candida species account for more than 75% of disseminated …
-
Development and evaluation of amphotericin B Loaded iron oxide nanoparticles for targeted drug delivery to systemic fungal infections
… system to diagnose and treat life threatening invasive fungal infections (IFIs) such as cryptococcal meningitis was designed, developed, characterized, and evaluated. To address the development processes, first, iron oxide nanoparticles (IONP) (34-40 nm) coated with bovine serum albumin (BSA), …
-
Infecções fúngicas invasivas em neonatos, epidemiologia e perfil de susceptibilidade antifúngica dos agentes etiológicos
Infecções fúngicas invasivas têm se tornado cada vez mais freqüentes em neonatos, principalmente devido ao aumento da sobrevivência de prematuros e a deficiência do sistema imune. Dessa forma, torna-se relevante o conhecimento dos fatores epidemiológicos e susceptibilidade aos antifúngicos, uma vez …
-
Validation and Application of a Novel Target-Based Whole-Cell Screen to Identify Antifungal Compounds
… to apply this technique in the prevalent human fungal pathogen Candida albicans and validated this approach using dihydrofolate reductase. However, our approach, which we have termed target abundance-based fitness screening (TAFiS), should be applicable to an extensive array of molecular targets …
-
Synthesis and characterization of new light emitting probes for sensitive detection of bio-molecules and live cells
… of fluorescent derivatives of the antifungal drugs, posaconazole and caspofungin, for diagnostic imaging of fungal cells. Invasive fungal infections (IFI's) are a growing threat to human health particularly, with increase in the number of immune-compromised patient population, such as …
-
Examining How Non-Antifungal Medications Impact Host-Fungal Interactions
<p>Invasive fungal infections (IFIs) are estimated to kill 1.5 million people each year with mortality rates remaining high (around 30-70%), despite the availability of three major classes of antifungal drugs. Furthermore, millions more suffer debilitating infections of the mucosal membranes or …
-
Transcriptional Regulation of Azole Antifungal Resistance and Tolerance in Candida Glabrata
<p>Azole antifungal resistance has emerged as a significant problem in the management of infections caused by fungi including <em>Candida</em> species. In recent years, <em>Candida glabrata</em> has become the second most common cause of mucosal and invasive fungal infections in humans second to …