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Showing 1 to 20 of 964 for “"Intrinsically"”.
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Probing Order within Intrinsically Disordered Proteins
… the field of natively unfolded – or so-called intrinsically disordered – proteins, is rapidly developing. Protein disorder content has been positively correlated with organismal complexity, with over thirty percent of eukaryotic proteins predicted to contain disordered regions. However, the …
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Intrinsically Disordered Proteins within the Genome
The hundreds of millions of DNA base pairs within eukaryotic cells are not found free but packed inside the micrometre-sized nuclei through the formation of a macromolecular structure known as chromatin. Chromatin consists of a chain of nucleosomes – nucleoprotein complexes where the DNA makes …
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Intrinsically Localized Lattice Vibrations in Crystalline Lattices
We examined the formation of Intrinsically Localized Modes (ILMs) for a pair of harmonic phonons along the direction [111] of the Sodium Iodide (NaI) crystalline lattice. The tendency for ILMs to form at a certain center-of-mass momentum ▁q and corresponding relative momentum vector ▁k is …
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Modeling and simulation of intrinsically disordered biomolecular systems
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-05-01
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Intrinsically secure communication in large-scale wireless networks
… an information-theoretic definition of the intrinsically secure communications graph (iS-graph), based on the notion of strong secrecy. The iS-graph is a random geometric graph which captures the connections that can be securely established over a large-scale network, in the presence of …
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Decoding the Sequence-Dependent Properties of Intrinsically Disordered Proteins
… binding partner, thus imparting functionality. Intrinsically disordered proteins (IDPs) lack a well-defined structure yet manage to interact with a variety of partners. At a basic level we can use amino-acid sequences to predict disordered content, but the sequence profile of an IDP can tell us …
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Intrinsically disordered proteins in molecular recognition and structural proteomics
Intrinsically disordered proteins (IDPs) are abundant in nature, being more prevalent in the proteomes of eukaryotes than those of bacteria or archaea. As introduced in Chapter I, these proteins, or portions of these proteins, lack stable equilibrium structures and instead have dynamic …
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Investigating Cold Adaptation of Intrinsically Disordered Proteins in p53 Homologs
No abstract prepared.
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Structural and functional studies of intrinsically disordered fibronectin-binding proteins
… (Fn). FnBPs are predicted to contain a series of intrinsically disordered Fn-binding repeats (FnBRs), which undergo a disorder-to-order transition on binding up to five F1-modules (1−5F1) from the N terminal domain of Fn through a tandem β-zipper interaction. This work investigated these …
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An investigation of intrinsically disordered proteins in Gram-negative bacteria
Sporulation in Gram-positive bacteria results in the production of small acid-soluble proteins (SASPs) to coat the spore DNA and shield it from UV radiation. While orthologs of these SASPs exist in many sporulating and non-sporulating bacteria, they are noticeably absent from the Gram-negative …
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Serial digital multiplexing of transducer data for intrinsically safe applications
… The aim of the work here has been to realise an intrinsically safe fibre optic multi-drop bus utilising an unbroken fibre as the transmission path. The technique employed involves the modulation of light within the fibre using an acoustic wave to vary the characteristics of a multi- mode fibre …
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Modeling intrinsically disordered proteins ; a comprehensive study of [alpha]-synuclein
… challenging to study because it is an Intrinsically Disordered Protein (IDP); i.e., it lacks a well-defined structure in aqueous solution. Unlike folded proteins, IDPs typically interconvert between many different conformations during their biological lifetime. In this thesis we apply …
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Production of Bio-based Lactone Monomers for Intrinsically Recyclable Plastics
The development of intrinsically recyclable plastics is crucial to halt the accumulation of waste plastics in the environment. While great strides have been made in the design of novel polymers that exhibit desirable qualities and degrade back to their respective monomer at mild conditions, the …
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A Highly Charged Topic: Intrinsically Disordered Proteins and Protein pKa Values
Intrinsically disordered proteins (IDPs) are known not only for their roles in disease but also for their conformational flexibility, which makes them elusive for experimentation. We consider the role played by theory and simulation in resolving important questions pertaining to IDP structure and …
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Sequence-Based Properties that Identify Intrinsically Disordered Phase-Separating Protein Regions
… drive liquid-liquid phase separation (LLPS) of intrinsically disordered proteins (IDPs). This phenomenon is critical in many cellular processes (including RNA metabolism, chromatin rearrangement, and signal transduction), and known to be driven primarily, but not exclusively, by IDPs. To fully …
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Intrinsically Disordered Protein Polymer Libraries as Tools to Understand Protein Hydrophobicity
<p>Intrinsically disordered protein polymers (IDPPs) are repetitive biopolymers that, when enriched with prolines, glycines, and aliphatic amino acids, have observable lower critical solution temperature (LCST) phase transition behavior at physiologically relevant temperature and concentration …
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Primary Structure and Solution Conditions Determine Conformational Ensemble Properties of Intrinsically Disordered Proteins
<p>Intrinsically disordered proteins (IDPs) are a class of proteins that do not exhibit well-defined three-dimensional structures. The absence of structure is intrinsic to their amino acid sequences, which are characterized by low hydrophobicity and high net charge per residue compared to folded …
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Disengagement From Intrinsically Transient Social Worlds: The Case of a Distance Learning Community
… participants undertake as they disengage from an intrinsically transient social world. Taken together, these twelve dimensions model the process of disengaging from an intrinsically transient social world.
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