Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 34 for “"Intrinsic resistance"”.
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Metabolic vulnerability in HER2-positive Breast Cancer
… patients. However, almost all patients develop resistance either from the beginning of therapy or with prolonged treatment in two years. </p><p>Previous studies to unveil the resistance mechanisms were mainly focused on acquired resistance, culturing cells with HER2 inhibitors and making …
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Barriers to tuberculosis drug discovery: the mycobacterial cell wall
… complex macromolecular structure that provides intrinsic resistance to several anti-tuberculosis drugs, making it critical in the success of Mycobacterium tuberculosis infection. Multiple layers encapsulate the cell membrane, including arabinogalactan chains and mycolic acids that are covalently …
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Development, synthesis and anticancer evaluation of trinuclear Platinum Group Metal organometallic complexes
… properties of cisplatin. However, acquired and intrinsic resistance, toxicity and a host of side-effects have encouraged the research for new metal based anticancer agents. Organometallic complexes have proved to be successful anticancer agents and several have commenced clinical trials. The aim …
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Threat of Carbapenem Resistant Enterobacteriaceae and the Rise of Antibiotic Resistance
Antibiotic resistance is no new phenomenon. Evidenced by the presence of intrinsic resistance, microbes have had mechanisms to subvert antimicrobials for a very long time. Improper and poor use of antibiotics has further exacerbated the prevalence of antibiotic resistance in the microbial world, …
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RESISTANCE TO VESICULAR STOMATITIS VIRUS IS INTRINSIC TO PC3 PROSTATE CANCER CELLS AND CAUSES INHIBITION OF EARLY STEPS OF THE VIRUS REPLICATION CYCLE
… this thesis was to determine the mechanism(s) of resistance of prostate cancer cells to the oncolytic activity of vesicular stomatitis virus (VSV). In Chapter 1 I analyzed the timing of the different steps of the virus replication cycle in PC3 prostate cancer cells (VSV-resistant cells) to LNCaP …
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Phylogeny of the Resistance-Nodulation-Cell Division (RND) Superfamily
… study spans all domains to understand the Resistance-Nodulation-Cell Division (RND) superfamily’s evolution and points of divergence. Several members of the superfamily are involved in both the acquisition and intrinsic resistance to antibiotics despite origins that are ubiquitous and …
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Role of C-Met and Egfr In Acquired Resistance to Parp Inhibitors In Triple-Negative Breast Cancer
… is modest, suggesting the emergence of resistance. We previously demonstrated that c-MET contributes to intrinsic resistance to PARP inhibitors in triple-negative breast cancer. However, whether c-MET plays a role in acquired resistance to PARP inhibitors in triple-negative breast cancer …
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DISSECTING RESISTANCE TO IMMUNOTHERAPY IN MSS COLORECTAL CANCER
… Based on our results, MSS tumors seem to be intrinsically unsensitive to the immune system activity. Exploring the unknown causes, we identify that soluble factors secreted by MSS cells hinder neoantigen-mediated recognition in MSI CRC cells. This comprehensive approach challenges the …
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Purification and characterisation of the Escherichia coli multidrug efflux protein MdtM
Multidrug resistance (MDR) is the simultaneous acquisition of resistance by bacteria to a broad spectrum of structurally dissimilar compounds to which they have not been previously exposed. The principle cause of MDR has been identified as the efflux of antimicrobials from the cell by proteins …
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MICROWAVE ACTIVE INDUCTOR ANALYSIS AND DESIGN
… The conventional passive inductor has an intrinsic resistance and a stray capacitance, which will severely affect its quality factor and available frequency band in the circuit design. In this project, some novel microwave active inductors and the designed circuit configurations are …
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Pre-clinical evaluation of inhibitors of apoptosis protein (IAP) antagonists in colorectal cancer
… less than 10% when diagnosed at Stage IV. Drug resistance is a major limitation to current treatment options for advanced CRC. Consequently, there is an unmet clinical need for novel therapeutic agents for treating patients with CRC in the advanced disease setting. <br/><br/>CRC is frequently …
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Identification of Oncogenic KRAS-Associated Vulnerabilities in Non-Small Cell Lung Cancer
… in FSTL5 and mutations in Hippo pathway. The intrinsic resistance was reversed by coadministration of YAP1/TEAD inhibitor. Thus, our study suggests that XPO1 can be exploited for a promising therapeutic opportunity for KRAS mutant lung cancer and provides strategies for genomics-guided …
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Integrative genomic approaches to dissecting host-tumor and host-pathogen immune processes
… of extrinsic apoptosis as key strategies of resistance to cytolytic activity. Genetic amplifications were also associated with high cytolytic activity, including immunosuppressive factors such as PDL1/2 and ALOX12B/15B. Our genetic findings thus provide evidence for immunoediting in tumors …
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Delineating the Upc2A Regulon in Candida glabrata
… most common cause of invasive candidiasis. Intrinsic resistance has greatly limited the utility of the triazole antifungal, fluconazole, in the treatment of invasive fungal infection. The transcription factor Upc2 regulates the expression of sterol biosynthesis genes in yeast. Disrupting …
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Understanding the intrinsic antibiotic resistance in Lysobacter enzymogenes, a ubiquitous environmental bacterium
… to many antibiotics, resulting in multidrug resistance (MDR). Increased understanding of antibiotic resistance in environmental bacteria provides new targets for discovery of novel therapeutics. However, little is known about the antibiotic resistance of the vast majority of environmental …
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Identification and characterization of farR and farE as a regulator and effector of fatty acid resistance in Staphylococcus aureus
… mechanisms for regulating gene expression and intrinsic resistance in response to these fatty acids have not been reported. Through in vitro selection for increased resistance of S. aureus to linoleic acid, I identified fatty acid resistant clone FAR7, where a single nucleotide polymorphism …
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Decoding The Evolutionary Response to Prostate Cancer Therapy Using Plasma Genome Sequencing
… therapy and harbored mutations associated with resistance. Furthermore, we applied PEGASUS to profile a larger cohort of 79 prostate cancer patients with 2-10 longitudinal samples. A single time point analysis of 49 patients revealed extensive interpatient-heterogeneity and recurrent aberrations …
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The plasticity of diamond
… the suggestion that this element reduces the intrinsic resistance to dislocation movement and encourages the initiation of cracks in the diamond structure.
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Functional Interrogation Of Anti-Cancer Drug Resistance
… ability to resist upfront target inhibition (intrinsic resistance) as well as, in cases where tumors are initially sensitive, develop resistance over the course of drug treatment (acquired resistance). The literature to date reveals a problem as complex as the tumor itself; the heterogeneity …
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Riboswitch regulation of methionine metabolism and vitamin B12 uptake in mycobacteria – implications for drug susceptibility and pathogenesis
… investigate the link between cobamides and the intrinsic resistance to anti-folate antibiotics confirmed novel mycobacterial vulnerabilities in cobamide-related methionine metabolism, indicating that the outcomes of cobamidedependent regulation may have relevance to mycobacterial pathogenesis …
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