Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 28 for “"Intrinsic activity"”.
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Approaches to Understanding the Function of Intrinsic Activity and its Relationship to Task-evoked Activity in the Human Brain
… paradigm treated underlying spontaneous brain activity, a.k.a. intrinsic activity, as noise hence irrelevant to cognitive or behavioral functions. This view, however, has been profoundly modified by the discovery that intrinsic activity is not random, but temporally correlated at rest in widely …
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Amino acids regulate the transcription, internal sorting, and intrinsic activity of the general amino acid permease (GAP1) in S. cerevisiae
… amino acid levels are low. Regulation of activity allows the cell to rapidly and reversibly modulate amino acid import according to the nitrogen requirements of the cell. I have explored three distinct modes of action by which amino acids repress GAP1 activity: transcriptionally, by …
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Regulation of survival and synaptic connectivity in the adult brain by cell-intrinsic excitability
… knowledge in our understanding of how the cell-intrinsic excitability of new neurons governs their incorporation into mature circuits in the adult brain. Contrary to the notion that adult neurogenesis represents continual addition of the same type of neurons that are incorporated during brain …
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Sample Path Analysis of Integrate-and-Fire Neurons
… to complex naturalistic stimuli. If neural activity can be assumed to be primarily driven by the stimulus at early stages of processing, the intrinsic activity of neural circuits interacts with their high-dimensional input to transform it in a stochastic non-linear fashion at the cortical …
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The Extracellular Domains of the AMPA, Kainate, and Orphan Delta Receptor Regulate Channel Gating in Distinct Ways
… function through fast glutamate-gated ionotropic activity, which needs precise structural changes to perform properly. While Cryo-EM structures have provided snap shots of these proteins, questions remain regarding the dynamics across conformations and individual roles of the extracellular …
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Nanocrystalline perovskites for catalytic combustion and oxygen separation
… nm and a surface area of 19 m2/g. The catalytic activity of these perovskites was investigated for different A- and B-site substitutions. Among LaBO3 perovskites, the catalytic activity was found to decrease in the order: Mn > Fe [approx.] Ni > Co, with LaMnO3 showing the lowest light-off …
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Asymmetric reduction using enzymes and Chiral chemical reagents
… be obtained. This was primarily due to the low intrinsic activity of the enzyme. To complement the enzymic studies the chiral chemical reduction of dihydrofolic acid was investigated. The sepamtion of the C6 epimers was thus particularly important for the assessment of the efficiency of the …
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Investigation of potential intervention targets to improve insulin action: a therapeutic approach
… of PI 3-kinase, possibly via an increase in the intrinsic activity of glucose transporters. Neither tolbutamide nor thiazolidinediones directly altered insulin sensitivity in L6 skeletal muscle cells: however vanadyl sulphate and thioctic acid increased glucose transport but appeared to exert …
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Understanding the catalytic activity of oxides through their electronic structure and surface chemistry
… to develop descriptors to improve catalytic activity, thus reducing material cost for commercial technologies, this work studies fundamental processes that occur on model catalyst systems. Electrochemical studies of epitaxial oxide thin films establish the intrinsic activity of oxide …
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Modelling resting-state neural oscillations to uncover circuit mechanisms of aging and rTMS response in late-life depression
Understanding the brain's intrinsic activity is essential for advancing treatments for psychiatric and neurological disorders. Resting-state oscillations are rhythmic neural patterns observed when the brain is not engaged in a specific task, measurable via magnetoencephalography (MEG) or …
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Gas Phase Oxidation of Levulinic Acid for the Production of Maleic Anhydride over Supported Vanadium Oxide Catalysts
… extent to which vanadate structure dictates reactivity and selectivity, we consider the oxidative cleavage of 2-pentanone over a number of vanadium oxide catalysts that vary in both vanadium oxide structure and support. We observe that activity and selectivity on supported vanadium oxides is …
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Ligand participation in energy storage electrocatalysis and photocatalysis
… The thesis begins by investigating the reactivity of nickel porphyrins during the electrocatalytic generation of hydrogen from acid. Rather than forming a traditional metal-hydride intermediate, nickel porphyrins are found to be protonated on the macrocycle ligand to first form a phlorin …
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Synthesis, Characterization, and Antimicrobial Activity of Water-soluble, Tri-carboxylato Amphiphiles
Many previous studies of biological activity in a homologous series of amphiphiles have shown a cut-off effect, where the biological activity increases with an increase in chain length, after which the activity plateaus or weakens. One factor suspected to cause this problem is solubility issues. We …
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Synthesis and biological studies of a fullerene-Taxol conjugate and fullerene-based transfection vectors
… problem. The conjugate was designed to have no intrinsic activity by modifying 2'-hydroxyl group of Taxol and to release the active drug via enzymatic hydrolysis of a 2'-ester bond. The conjugate synthesis involved the synthesis of Taxol-2'-succinate and a fullerene aminoderivative and then …
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Correlative ex-situ analysis and operando ellipsometric investigation during oxygen evolution reaction of mesoporous iridium oxide model catalysts
… of the data from the VEEL spectra with activity measurements of the oxygen evolution reaction (OER) suggests that the intrinsic activity (surface charge normalized activity) of IrOx scales with interband transition energies between the Ir 5d t2g sub-level and the O 2p orbital. For SE …
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Assessing functional connectivity in the newborn brain using fNIRS
… represents a powerful approach to describe the intrinsic activity of the brain. It reveals the organization and correlations among anatomically separated regions supporting similar cognitive and sensory processes. Using functional Magnetic Resonance Imaging (fMRI), the recurrent spatial …
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SYNTHESIS AND CHARACTERIZATION OF RESVERATROL AND ITS CONJUGATED METABOLITES AND CONTRIBUTION OF METABOLISM TO ITS DECREASED BIOVAILABILITY
… possibility that resveratrol metabolites possess intrinsic activity and thus contribute to the observed effects of the parent. The mono-sulfated and glucuronidated conjugates of trans-resveratrol were synthesized and tested for antiproliferative activity in a panel of mammalian cell lines. Their …
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River oxygen uptake by benthic microorganisms
… depths were estimated from chamber and sediment intrinsic activity measurements and ranged from 0.32 to 32 cm, with minimum values for ‘sewage fungus’ biofilms. Actual measurements of interstitial DO for 2 pumice bed rivers, showed DO present down to at least 10 cm in the Waiotapu River and down …
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Nuovi catalizzatori per l'idrogenazione, l'idrogenolisi/ring-opening di composti aromatici policiclici
… ring-opening rates and selectivity. High intrinsic activity may be enhanced by deposition of noble metals on acidic, high surface area supports, because it is possible to arrange close proximity of the metal and acid sites. Moreover, in large-pore supports, the diffusion resistance of …
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Synthesis, Characterization, Critical Micelle Concentration and Biological Activity of two-Headed Amphiphiles
… acids having the lowest CMCs. Antibacterial activity (minimal inhibitory concentrations, MICs) for a series of homologous dendritic two-headed amphiphiles and three series of homologous, three-headed amphiphiles against Staphylococcus aureus and methicillin-resistent S. aureus (MRSA) were …
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