Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Intrinsic Factor"”.
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Toward a Cell-Based Assay for Cubam-Mediated Intrinsic Factor-Vitamin B12 Binding and Uptake
Background: Vitamin B12 deficiency caused by intrinsic factor (IF) autoantibodies can lead to pernicious anemia. The 2025 iGEM project aimed to develop a novel oral B12 supplement capable of escaping autoantibody recognition. This study was designed to complete and continue the iGEM project with …
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Mosaic Analysis of Neurogenesis and Neuronal Morphogenesis in Drosophila Learning and Memory Center Mushroom Bodies
… analysis shows that Chinmo is an important intrinsic factor involved in birth order-dependent specification of neuronal identities. These findings provide news insights into the mechanisms underlying neuronal morphogenesis and the generation of neuronal diversity.
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Exendin 4 Conjugation and Sequence Modification to Treat Type 2 Diabetes and Obesity
… Can B12 dietary uptake proteins such as gastric intrinsic factor offer protection to B12</p> <p>conjugated peptides or proteins (focusing on Ex-4), with a view to improving in vivo PK?</p> <p>Goal: To demonstrate (in vivo) that IF binding of B12-Ex-4 confers protection against gastric</p> …
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The Apical Polarity Complex Protein, Pals1, Regulates Cell Fate In The Development of Cerebellum and Neocortex
… Additionally, we uncovered a crucial downstream factor mediating Pals1 function, Pttg1, which is known as an essential protein for sister chromatid segregation during mitosis. Thus, our study identifies Pals1 as a new intrinsic factor required for the proliferation and differentiation of neural …
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Job satisfaction of emergency nurses in Tennessee
… care. The purpose of this study was to identify intrinsic and extrinsic factors that contributed to job satisfaction and dissatisfaction among emergency nurses, to determine if there was a relationship between emergency nurses' years of experience and job satisfaction, and to ascertain if there …
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Vitamin B12 Bioconjugates In Pharmaceutical Design
… that of the enteric B12 transport protein intrinsic factor (IF) and its receptor cubilin, and the expression and exploitation of IF/cubilin in pharmaceutical development.</p> <p>Q1: (Chapter 2) Does an 89Zr-B12 conjugate allow for improved background/noise ratio, relative to 99mTc and 64Cu …
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Socioenvironmental and demographic modifiers of aging in nonhuman animals
… predictor of mortality and the leading risk factor for many non-communicable diseases. However, not all individuals within a species exhibit the same age-related declines in health. For example, some individuals develop early-onset of age-associated diseases while others never develop certain …
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Integrin α2 and Akt in early hematopoiesis
… that hyperactivation of Akt, which is a key intrinsic factor regulating the homeostasis of HSCs, was incompatible with the survival and growth promoting ability of FMS-like tyrosine kinase 3-internal tandem duplication (FLT3-ITD) signaling in murine stem and progenitor cells. Prospective …
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Perceived factors associated with high and low job satisfaction among teachers
… This was a qualitative study of those factors which teachers with high and low job satisfaction perceived affected how they felt about their jobs. A sample of 200 tenured Virginia Beach teachers was randomly selected sent the Teacher Job Satisfaction Questionnaire (TJSQ). Eighty-four of …
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Biosystematics and Diversification in the Genus <i>Striga Lour.</i> (Scrophulariaceae) in Africa
… although the chances of self-pollination (intrinsic factor) are high, this alone cannot guarantee the reproduction isolation necessary for speciation.</p>
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Yellow Perch Production in Semi-Permanent Wetlands in Eastern South Dakota and Evaluation of a New Chemical Marking Tool for Juvenile Yellow Perch
… Because little information is available about factors influencing yellow perch production in semi-permanent wetlands, my objectives were to: 1) monitor yellow perch movement and habitat selection during and after spawn in Little Brush Waterfowl Production Area (WPA), 2) compare yellow perch use …
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Konstruktion eines bakteriellen Systems zum Export von Coenzym B<sub>12</sub>
… von TorA mit dem menschlichen B12-bindenden Intrinsic Faktor (IF) bzw. der B12-bindenden Untereinheit (MutB) der Methylmalonyl-CoA-Mutase aus E. coli fusioniert. Zur Detektion der gebildeten Fusionsproteine wurden an das 3`-Ende der Gene die Sequenz für einen His6- oder Strep-Tag angefügt. …