Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Intrinsic Dissolution Rate"”.
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Preparation of amorphous forms to increase the solubility of poorly soluble drugs using spray drying
… by Spray drying on apparent solubility and intrinsic dissolution rate was determined. All the spray dried composites exhibited higher apparent solubility and intrinsic dissolution rate when compared to the pure drugs and their physical mixtures. The stability of the spray dried composites …
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Clarithromycin nanocrystals for high-dose inhalation
… particles", in which nanocrystals are incorporated in a matrix shell are designed for deep-lung deposition while retaining good flow and dispersion. Hydroxypropyl methylcellulose (HPMC) served as a dual-function excipient, stabilising nanocrystals during milling and acting as the spray-drying …
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The development of a novel in vitro model suitable for the prediction of bioavailability
… responsible for the increased absorption rate observed in a novel paracetamol formulation and the development of novel ibuprofen tablet formulations containing alkalising excipients as dissolution promoters.Several novel dissolution methods were developed. A method to study the interaction …
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Physicochemical and tableting properties of crystallised and spray-dried phenylbutazone containing polymeric additives. Effect of polymeric additives (hydroxypropyl methylcellulose and a polyoxyethylene-polyoxypropylene glycol) on the crystalline structure, physicochemical properties and tableting behaviour of crystallised and spray-dried phenylbutazone powders
… directed torwards the improvement of drug dissolution characteristics of drugs with low aqueous solubility. This thesis has considered the controlled modification of drug dissolution profiles by means of incorporating low concentrations of hydrophilic polymers by different processes into a …
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Crystal engineering approaches to solid-state pharmaceutical systems
… supercooled melt. The study carried out demonstrates the ability to selectively crystallise the α polymorph of indomethacin using specific polymer substrates. The second theme details a crystal engineering strategy for a drug molecule to obtain a novel solid form. It is shown how knowledge of …
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Understanding the Solid State, Solubility and Dissolution Behavior of Cefuroxime Axetil Diastereomers in Interactive Mixture Formulations
… major objective of this project was to study the dissolution behavior of interactive mixtures containing CFA. Mechanically stable interactive mixtures were prepared utilizing the amorphous and crystalline forms of the drug with hydrophilic carrier particles. The dissolution rate of CFA was …
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Functional organic thin films under extreme confinement
… In my first study (Chapter 2), we demonstrated a control in film thickness of APIs in nanometer scale range (1.5 μm to 30 nm) as well as their morphology and molecular packing by varying simple processing parameters. Moreover, we also performed sequential deposition of multiple components …