Global ETD Search
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Showing 1 to 20 of 24 for “"Intraperitoneal injections"”.
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The Effects of Cyclohexylamine on Antibody Production in Rabbits
… in rabbits, a group of rabbits was given intraperitoneal injections of cyclohexylamine hydrochloride (CHA-HCL) at a concentration of 50 mg/kg/day. After 70 days of treatment with CHA-HCL, the animals were assayed for total gamma globulin, specific antibodies to bovine serum albumin and …
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Ο ΡΟΛΟΣ ΤΟΥ ΧΡΟΝΟΥ ΕΦΑΡΜΟΓΗΣ ΤΟΥ ΠΡΟΑΓΩΓΟΥ ΠΑΡΑΓΟΝΤΑ ΣΤΗ ΧΗΜΙΚΗ ΔΙΦΑΣΙΚΗ ΚΑΡΚΙΝΟΓΕΝΕΣΗ ΤΟΥ ΒΛΕΝΝΟΓΟΝΟΥ ΤΟΥ ΣΤΟΜΑΤΟΣ. ΠΕΙΡΑΜΑΤΙΚΗ ΜΕΛΕΤΗ ΣΕ ΛΕΥΚΟΥΣ ΕΠΙΜΥΣ
… 2 AND 3 ANIMALS RECEIVED EACH, TWO (ONCE A WEEK) INTRAPERITONEAL INJECTIONS OF CHEMICAL CARCINOGEN (NMU - 50MGR/KGBW). IN THESE ANIMALS ACUTE LIVER INJURY WAS INDUCED BY INJECTION OF D- GALACTOSAMINE (200 MGR/KGBW). CONTINUOUS CHRONIC, NON-SPECIFIC, MECHANICAL IRRITATION WAS APPLIED ON THE LEFT …
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Investigation of Nocifensive and Cellular Effects of Dihydroergotamine in a Model of Chronic Migraine
… capsule. Three and four days post-CFA-injection, intraperitoneal injections of DHE, sumatriptan, or vehicle control were delivered. I found that DHE, but not sumatriptan, was able to transiently inhibit CFA-mediated increases in nocifensive withdrawal behavior. Within the spinal cord, DHE was …
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Use of methionine sulfoximine to dissect the role of glutamine synthetase and glutamine in progression of acute liver failure
… liver failure (ALF) in mice, animals were given intraperitoneal injections of E. coli lipopolysaccharides (LPS) and sugar D-galactosamine (D-GalN). When these animals were pretreated with MSO, 80% of the animals were completely rescued from liver failure. Moreover, when we characterized the …
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Aspects of the feeding behaviour of intensively reared trout
… and satiety in the hypothalamus of brain by the intraperitoneal injections of goldthioglucose. Feeding under nine different constant photoperiods at 160 lux, at a temperature of 13.5°C, showed that trout exhibit a rhythmic pattern of feeding behaviour in all photoperiods except in continuous …
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Role of Betaine-Homocysteine S-Methyltransferase in Homocysteine Methylation
… Hcy (tHcy, 2.7-fold) for 8 hours. Repeated intraperitoneal injections of D,L-CBHcy (6 doses) additionally reduced the liver S-adenosylmethionine-to-S-adenosylhomocysteine ratio (65%). To assess whether BHMT inhibition affected liver and plasma amino acids, rats were fed 5mg D,L-CBHcy (9 …
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Peripheral regulation of food intake in the domestic fowl
… tryptophan depresses food intake was clarified. Intraperitoneal injections of tryptophan methyl ester were demonstrated to inhibit feeding in Single Comb White Leghorn (SCWL) cockerels. Intragastric intubations of tryptophan inhibited food intake and decreased body temperature of SCWL cockerels. …
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Role of the NLRP3 Inflammasome in bacterial keratitis
… administered as topical drops (10µL of 100µM) or intraperitoneal injections (100µL of 20 mg/mL) twice a day to the infected mice. Ocular grading was performed using a slit lamp. Numbers of viable bacterial, polymorphonuclear cells and macrophages, and cytokines concentrations in eye homogenates …
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1,25- dihydroxycholecalciferol-glycoside supplementation for LPS - challenged broiler chickens
… (SUP+LPS). The LPS challenge was administered as intraperitoneal injections at 21 and 23 days of age (1 and 1.12 mg/kg of body weight, respectively). Four hours after the first LPS injection, one bird per experimental unit was euthanized to collect blood, spleen, duodenum, and jejunum samples. …
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Targeting Neuronal Nitric Oxide Synthase (nNOS) for Melanoma Treatment
… an immunocompetent allograft mouse model, daily intraperitoneal injections of nNOS inhibitors (HH044 or MAC-3-190) exhibited significant anti-melanoma activity and inhibited tumor growth, which was enhanced when combined with immune checkpoint inhibitors. The co-treatment with HH044 and anti-PD-1 …
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The Effects of post-training strychnine treatment of the long term retention of discrimination training by mice
… second training trial, mice were administered intraperitoneal injections of either strychnine sulphate (1 . 0 mg/kg) or physiological saline. After retention intervals of either 1, 3, or 27 day s, mice were tested under either complete cue reversal (both training cues were reversed), partial …
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LOCOREGIONAL DELIVERY OF UNMETHYLATED CPG-OLIGODEOXYNUCLEOTIDES TO CANCER THERAPY: PRECLINICAL STUDIES
… to the peritoneal cavity, therefore repeated intraperitoneal injections of CpG-ODN recruiting and activating innate effector cells throughout the abdominal cavity to the tumor site might control tumor cell growth and ascites formation. After a single CpG-ODN treatment, in IGROV-1 ovarian tumor …
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Characterization and Role of Secretoneurin in the Ovulatory Cycle of Zebrafish
… bioactivity of SNa1-34 and SNa1-14, we performed intraperitoneal injections and analyzed the expression numerous reproductive genes. The results suggested that SNa1-34 could induce ovulation by stimulating time-dependent expression of gnrh3 in brain, cga and lhb in pituitary and npr in ovaries. In …
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Dietary Protein Concentration and the Metabolism of 1,2-Dimethylhydrazine by Mice
… In time course studies employing subcutaneous or intraperitoneal injections of the text chemicals, host-mediated mutagenesis was increased by AOM in 20 min while DMH-induced activity required at least 1 hr. When {('14)C}-DMH was administered {('14)C}-azomethane was expired immediately, while …
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The effects of nitrosoureas on Thymocyte differentiation and T cell activation
… mice. Treatment of normal C57BL/6 mice with 5 intraperitoneal injections of 20 mg/kg body weight of BCNU or CLZ caused an increase in the percentage of CD4⁻ CD8⁻ T cells and a decrease in the percentage of CD4⁺CD8⁺ T cells in the thymus. In addition, such treatment also caused an increase in …
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The effects of hypoxis hemerocallidea on blood glucose levels in rats with Type 2 diabetes
… 200, 400, 800 mg/ml). Diabetes was induced by intraperitoneal injections of STZ (65mg/kg). Two weeks after the injection (STZ 65 mg/kg), different concentrations of HHS was administered intraperitoneally after an overnight fast. The blood glucose levels were monitored in the diabetic and …
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The Role of Il-6 In Adenosine-Mediated Pulmonary Fibrosis
… mice were subjected to intraperitoneal injections of bleomycin twice a week for four weeks. Results demonstrated that <em>IL-6<sup>-/-</sup></em> mice developed reduced pulmonary fibrosis. To examine a therapeutic approach in this model, wild type mice exposed to …
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Long-term effects of LPS and high-fat diet on dopaminergic neurodegeneration
… (HFD). All mouse groups were challenged with intraperitoneal injections of either saline or LPS (5 mg/kg; one or five times on a monthly basis). Significant genotype and diet effects were observed in behavioral, metabolic and inflammatory outcomes over a period of 9 to 15 months, whereas the …
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Long-term effects of LPS and high-fat diet on dopaminergic neurodegeneration
… (HFD). All mouse groups were challenged with intraperitoneal injections of either saline or LPS (5 mg/kg; one or five times on a monthly basis). Significant genotype and diet effects were observed in behavioral, metabolic and inflammatory outcomes over a period of 9 to 15 months, whereas the …
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