Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 43 for “"Intramolecular interactions"”.
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X-Ray Crystallographic Studies of Short Intramolecular Interactions Involving Sulfur, Selenium and Oxygen
Made available in DSpace on 2014-12-10T23:01:37Z (GMT). No. of bitstreams: 1 7317588.pdf: 5509083 bytes, checksum: 6e4480430a3a9f5d8b3da0b81c3b72cd (MD5) Previous issue date: 1973
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Examination of intramolecular interactions between residues of the cys-loop GABA receptor Hco-UNC-49 from Haemonchus contortus
… The objective of this thesis was to characterize intramolecular interactions of Hco-UNC-49B. Two sets of oppositely charged residues were chosen based on their proximity to each other in a model of Hco-UNC-49 generated using the C. elegans GluCl crystal structure as a template. These residues are …
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A study of inter- and intramolecular interactions through neutron compton scattering and low temperature matrix isolation infrared spectroscopy
… solvents, thought to be due to solvent-solvent interactions limiting solvent availability to the polymer. Deuterium labels were introduced in neutron scattering experiments, and expected to show significant momentum change with this collapse of hydrogen bonding.
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The intramolecular domain interactions and phosphatase activation mechanisms of Shp2
… PDGFRβ induced a significant FRET increase via intramolecular interaction between C-SH2 and phosphotyrosine 580 (pY580). The phosphotyrosine 542 (pY542) has an adverse position despite a favored surrounding amino acid sequence such that it can only bind to C-SH2 in the absence of pY580. In …
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Design and Synthesis of Molecularly Encapsulated Conjugated Materials for Organic Electronics.
… attributed to their intermolecular and intramolecular interactions. In conjugated polymers, charges or excitons can transport either along the conjugated backbone or intermolecularly via π-stacking interactions. Yet, our understanding of what each type of interaction contributes, is …
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Enabling tools for de-novo single molecule protein sequencing
… hurdle in protein sequencing is overcoming the intramolecular interactions between amino acids that compete, prevent access, or interfere with the function of reagents that can detect amino acid side chains. Current solutions involve denaturation agents that are transient, harsh, and can …
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Investigation of Neural and Epithelial Cadherin Monomer Properties Using a Molecular Dynamics Approach
… the testing of specific hypotheses regarding the intramolecular interactions of neural and epithelial cadherin. We particularly focus on interactions involving critical residues at the N-terminus of the proteins, the hydrophobic core residues, and the ionic surface area.
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Regulatory domains of the Arf GEF Sec7 scaffold autoinhibited and active conformations
… by the Arf GEF Sec7. A network of inter- and intramolecular interactions of Sec7 gives robust spatiotemporal specificity to the potent Arf GEF. The Sec7 homodimer is autoinhibited, and interactions with Rab1, Rab11, Arl1, Arf1 and the membrane recruit Sec7 and stimulate activity. These …
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Functional Genomic Approaches to Study Cell Polarity Regulation by G1 Cyclins in Saccharomyces cerevisiae
… by systematically identifying their genetic interactions. To do this, I conducted Synthetic Genetic Array (SGA) screens using strains deleted for different combinations of cyclin genes. The results of screens with strains deleted for the G1 cyclin pairs, CLN1, CLN2, or PCL1, PCL2, confirmed a …
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Structural and Molecular Mechanisms of Centrosome Assembly and Strength
… for mitotic spindle assembly. The molecular interactions that enable PCM to assemble and resist external forces are poorly understood. To answer such question, we use cross-linking mass spectrometry (XL-MS) to analyze PLK-1-potentiated multimerization of SPD-5, the main PCM scaffold protein …
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Molecular Biophysics of Mammalian and Fungal Macromolecular Assemblies
… organization of an ordered structure, and even intramolecular interactions of nuclei. This thesis details two projects that utilized NMR to gain a higher understanding of two macromolecular assemblies; each project has been divided into two separate chapters. Chapter One describes the study of …
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Thermodynamically Driven (Reversible) End-Capping of Pseudorotaxanes to Produce Rotaxanes
… by the host molecule via chemical equilibrium. Intramolecular interactions such as hydrogen bonding and π-π stacking facilitate threading to form the pseudorotaxane which is endcapped to form the thermodynamically stable rotaxane. In this work, the synthesis and characterization of rotaxanes …
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Comparative evaluation of two carbohydrate force fields for modelling polysaccharide conformation
… glycosidic linkage that are stabilised by strong intramolecular interactions. The reduced consideration for repulsive Coulombic forces in GLYCAM06, originating from a collective lack of partial aliphatic hydrogen charges, is likely the principle factor behind these differences. This work suggests …
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DNA Walkers: Emerging Analytical Applications, Biomolecular-Nanomaterial Probes and Biomolecule Sensors
… DNA walkers capable of probing dynamic interactions occurring at the biomolecule-nanoparticle (bio-nano) interface. By monitoring dynamics of DNA walkers on spherical nucleic acid (SNA) tracks, we systematically investigated effects of varying interfacial factors, including …
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A structure-reactivity study of selected phosphate esters
… compound (4) donor-acceptor nitrogen-phosphorus interactions change the geometry of the molecule from tetrahedral to quasi trigonal bipyramidal, thus the structure may be considered as an "early stage" of the intramolecular displacement of the 4-ni trophenoxide group. In the diester (6) this …
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Life in a drop of water
… biochemically map the functional groups making intramolecular interactions that permit activity in an in vitro-evolved RNA enzyme, the class I ligase ribozyme; although this ribozyme, derived from random sequence, has never been a part of any organism, understanding its structure and …
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The structure and function of the human ghrelin receptor
… to the activation of Family A GPCRs, with interactions between the two helices stabilising the ground state. During activation conformational rearrangements result in these interactions being broken, with new contacts forming and stabilising the active state. Investigation of the ghrelin-R …
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Regulation of the histone H3K36 methyltransferase Set2 by the histone chaperone Spt6
… Set2 mutants that likely impair either Set2-Spt6 interactions or the Set2 intramolecular interactions underlying Set2 autoinhibition. The Set2 autoinhibition mutants contain mutations within the Set2 catalytic domain at a predicted interface with the Set2 AID, which is in support of the …
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Protein Mechanics Through X-Ray Crystallography
… comprehensive knowledge of the energetics of intramolecular interactions in model proteins is essential. Here, we present three approaches which begin to address this problem, each through a different form of perturbation to a series of members of the PDZ protein family. First, we show that …
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The Role of Force-Sensitive Interactions in Amyloid Assembly by Fungal Adhesins
… other adhesin β-sheets by sidechain–sidechain interactions to form highly stable amyloid fibrils. The Als (agglutinin-like sequence) proteins are one type of the amyloid fibril-forming adhesin that decorates the cell wall of C. albicans and have been implicated in pathogenesis and biofilm …
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