Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Intramembrane proteolysis"”.
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Inhibition of Cell Proliferation through Regulated Intramembrane Proteolysis of CREB3L1
… bound precursor and activated by regulated intramembrane proteolysis in response to stimuli like ER stress. By comparing gene expression between Huh7 subclones that are permissive for hepatitis C virus (HCV) replication versus the non-permissive parental Huh7 cells, we identified CREB3L1 as …
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Interrogating regulated intramembrane proteolysis of IGF-1R, and its role in cell migration
… substrate for gamma-secretase-mediated regulated intramembrane proteolysis (RIP). This proteolytic pathway begins with ectodomain shedding, mediated by sheddases, which produces a soluble fragment in the extracellular space. Following ectodomain shedding, a membrane anchored C-terminal fragment …
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Regulated intramembrane proteolysis in the control of the Bacillus subtilis anti-sigma factor RsiW.
… RsiW is degraded by the mechanism of regulated intramembrane proteolysis (RIP). This process involves two site-specific proteolytic cleavage events in the extracytoplasmic part (site-1) and in the transmembrane domain (site-2) of RsiW. In consequence, SigW is released to interact with the …
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Intramembrane Proteolysis Mediated by the gamma-Secretase Complex : Nicastrin Functions as a Substrate Receptor
… nicastrin, Aph1, and Pen-2; (2) catalyzes the intramembrane cleavage of a broad range of substrates, regulating physiology from neurodevelopment to neurodegeneration. The aim of this thesis is to elucidate the mechanism by which the gamma -secretase recognizes its substrates. I provide evidence …
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Identification and characterization of innate immune receptor substrates of γ-secretase enzyme complex
… protease complexes and associated regulated intramembrane proteolysis play an important role in controlling receptor-mediated intracellular signalling events, which have a central role in Alzheimer’s disease, cancer progression and immune surveillance. It has previously been reported that the …
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Ceramide-Induced Alternative Translocation of TM4SF20
… helices that inhibits the Regulated Intramembrane Proteolysis (RIP) of the transcriptional factor CREB3L1 (cAMP response element binding protein 3-like 1), a transcription factor synthesized as a membrane-bound precursor. CREB3L1 RIP is induced by several stimuli: ER stress, viral …
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EWSR1 and FUS fusion genes in tumorigenesis
… results suggest that the chimera is regulated by intramembrane proteolysis like wt CREB3L2. In Article IV, low-grade fibromyxoid sarcoma (LGFMS), which is characterized by the FUS-CREB3L2 fusion, was found to have a specific gene expression profile, compared to histologically similar tumors types. …
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The Voltage Gated Sodium Channel β1/β1B subunits: Emerging Therapeutic Targets in the Heart
… may increase β1 adhesion by upregulating the intramembrane proteolysis of β1, a process which has important downstream implications and effects on translation. Despite these exciting findings, we were unable to translate them into a primary culture of cardiac cells with endogenous expression …
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Investigation of p75 neurotrophin receptor and the role of its post-translational modifications in tumour cell motility and invasiveness
… shown to undergo γ-secretase-mediated regulated intramembrane proteolysis, and the receptor ICD was found to migrate to the nucleus where it regulates gene transcription. Moreover, γ-secretase-mediated proteolysis was shown to be involved in glioblastoma cell migration and invasion. In this study …
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Solution structure and biochemistry of an intramembrane aspartyl protease (IAP)
Intramembrane proteases (IPs) play important roles in numerous biochemical processes in all kingdoms of life, including cell differentiation, development and metabolism. IPs are attractive targets for therapeutics development and have been implicated in the pathogenesis of human diseases, such as …