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Showing 1 to 2 of 2 for “"Intramembrane chaperone"”.
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Biogenesis of Multipass Membrane Proteins
… complexes: the Sec61 translocation channel, an intramembrane chaperone called PAT, an Oxa1 insertase family member called GEL, and a complex of unknown function termed BOS. Structural and mutational analysis showed that the PAT complex contains a membrane-exposed amphipathic surface that binds …
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Mechanisms of multipass membrane protein biogenesis
… we define the engagement of a newly identified intramembrane chaperone protein complex that we term the PAT complex. The PAT complex is an obligate heterodimer consisting of the highly conserved proteins CCDC47 and Asterix. A diverse set of multipass membrane proteins show impaired biogenesis …