Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 67 for “"Intracerebral"”.
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Peripheral Leukocytes and Intracerebral Hemorrhage
… suffer significant disability from spontaneous intracerebral hemorrhage (ICH) every year. No proven treatment is available that improves ICH outcomes. Since hematoma volume is the strongest predictor of ICH outcome, limiting hematoma expansion has been the primary goal of recent ICH clinical …
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The Epidemiology of Intracerebral Haemorrahge. Risk factors and prognosis
… The present thesis explored the epidemiology of intracerebral haemorrhage (ICH), i.e., factors associated to incidence and prognosis. In the population of Malmö (Malmö 1990 cohort), it was shown that immigrants from China/Vietnam and the Former Soviet Union had higher risk of ICH than citizens …
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The role of substance P in experimental intracerebral haemorrhage.
… SP plays a similarly deleterious role following intracerebral haemorrhage (ICH). We further hypothesised that the post-ICH effects of intracerebral thrombin (which is known to play a major role in post-ICH secondary injury) are at least partly SP-mediated. Thrombin, similarly to SP, is known to …
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Mechanisms of Brain Edema Formation in Mouse Models of Intracerebral Hemorrhage
… causes major neurologic deterioration following intracerebral hemorrhage (ICH), mainly resulting from the disruption of the blood-brain barrier (BBB) by multiple mediators, including inflammatory mediators and thrombin. The objective of our study was to investigate the mechanisms by which …
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Blood pressure variability and the characteristics and outcomes of patients with intracerebral haemorrhage
… strongest modifiable risk factor for spontaneous intracerebral haemorrhage (ICH). International guidelines about the management of high BP for primary prevention of cardiovascular disease and secondary prevention after stroke refer to mean or 'usual' BP targets for office BP monitoring (long-term …
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ENDOSCOPE-ASSISTED EVACUATION OF INTRACEREBRAL HEMATOMAS (ICH)//Ендоскоп-асистирана евакуация на интрацеребрални хематоми (ICH)
Интрацеребралните хематоми (ИЦХ) са социално значимо заболяване с висока смъртност или тежка инвалидизация. Класическият метод за хирургично лечение на ИЦХ е широката краниотомия/ краниектомия с открита евакуация. Като възможна алтернатива се обсъжда ендоскоп-асистираната евакуация на ИЦХ. …
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Shuttlebox Self-Stimulation Behavior Following Intracerebral Microinjections of Morphine Into the Ventral Tegmental-Substantia.
Systemic analgesic injections of morphine have been shown to increase the rate at which rats will lever-press for electrical brain stimulation as well as decrease the current intensity required for this self-stimulation. In the shuttlebox paradigm, the animal crosses from one side of the case to …
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Evaluating Blood Pressure Methods in Non-traumatic Intracerebral Hemorrhage: A Two-site Prospective Observational Study
… complex in the treatment of acute non-traumatic intracerebral hemorrhage (ICH). Despite mean arterial pressure (MAP) being the most reliable measure of noninvasive automatic oscillometric (NIBP) in clinical practice, clinicians instead rely on systolic and diastolic blood pressure (SBP and DBP) …
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Multi-modality imaging assessment of cerebral small vessel disease biomarkers after stroke due to spontaneous intracerebral haemorrhage
In most cases, spontaneous intracerebral haemorrhage (ICH) is thought to result from cerebral small vessel diseases (SVDs). Cerebral amyloid angiopathy (CAA) and arteriolosclerosis (non-CAA SVD) are the two main types of SVD associated with ICH. The risk of recurrent ICH and post-stroke dementia …
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The Long Term (Five Year) Neuropsychological and Functional Outcomes of Primary Intracerebral Haemorrhage. A Population Based Study.
… and functional outcomes of primary intracerebral haemorrhage (ICH) using a population-based sample. The World Health Organisation‟s model of health outcomes; the International Classification of Functioning (ICF), was used to identify areas for consideration in characterising …
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The Neuropsychological and Functional Outcomes of Primary Intracerebral Haemorrhage (ICH) at 6 and 12 Month Follow Up: A Population-Based Study
… mood, cognitive, and functional outcomes of Intracerebral Haemorrhage (ICH). Previous research has tended to use hospital-based samples; examine stroke outcomes generally rather than specific to stroke subtype; assess outcomes only in the acute phase post-stroke; and favour functional …
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Experimental Models of Brain Hemorrhage Using Clostridial Collagenase
… States, and the most severe form is known as intracerebral hemorrhage, which is bleeding into the brain. The goal of this study is to establish novel animal models to buildup foundations for translational research of intracerebral hemorrhage. We, for the first time, established four animal …
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Desmoteplase zur lokalen Fibrinolyse intrazerebraler Blutungen in einem Großtiermodell
Recombinant Desmoteplase was used for lysis of intracerebral hemorrhages in a well-established large-scale animal model. The fibrinolytic potential of the plasmonogen activator, as well as the effect on the delayed edema was evaluated which is most prominent three to five days after ictus. We …
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Observations on the Sturge-Weber syndrome
… hardly be accepted as such; some are cases of intracerebral racemose angioma, some of the patients have a facial naevus but scanty neurological symptoms or deficits are recorded; a few lack the facial cutaneous stigma. A rather rigid definition of the Sturge Weber syndrome seems therefore …
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Incidencia de hemorragia intracerebral en pacientes postquirurgicos de resección de tumor cerebral por craneotomía, en la Unidad de Cuidados Intensivos Quirúrgica del Hospital Nacional Rosales de 01 enero a 31 de diciembre del año 2022
… es muy importante dado el riesgo de hemorragia intracerebral manifestado con deterioro neurológico. Entre los factores asociada a sangrado postquirúrgico de craneotomía de tumores se encuentran, comorbilidades como hipertensión arterial, trombocitopenia, uso de anticoagulantes y/o …
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MR-tomographische Untersuchungen zur Entwicklung eines verspäteten Hirnödems nach operativer Ausräumung intrazerebraler Blutungen im Schweinemodell
Objectives: Spontaneous intracerebral hemorrhage is associated with high mortality and morbidity. Despite of countless clinical and experimental trials, no evidence-based therapy can be recommended. The therapeutic alternatives include best medical therapy, surgical therapy via craniotomy and lysis …
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Avaliação do erro das coordenadas de localização estereotáctica guiada por tomografia computadorizada do encéfalo
… em cavidade tumoral, drenagem de hematoma intracerebral e drenagem de abscesso cerebral. As orientações de craniotomias foram para MAVs, tumores e processos inflamatórios, em 21 pacientes. As biópsias cerebrais estereotácticas para diagnóstico anatomopatológico apresentaram um índice de …
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Neurochemical and Neuroanatomical Basis Of Reversal Learning In The Rat
… were assessed, both systemically and via intracerebral infusions into different regions of the striatum. Systemic raclopride had no specific effects initially on serial reversal learning, but continued treatment with a low dose did impair retention of a novel visual discrimination, and its …
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An injectable, biomaterial-based therapy to promote endogenous neural progenitor cells in a hemorrhagic stroke lesion
… cells (NPCs) in the lesion. In a well-validated intracerebral hemorrhagic (ICH) stroke model in rats, NPCs were quantified and compared to ICH-only controls at 2 and 4 weeks post-injection.
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PRECLINICAL PHARMACOKINETIC AND PHARMACODYNAMIC EVALUATION OF NEW ANTICANCER AGENTS FOR BRAIN TUMOR CHEMOTHERAPY
… tumor penetration and activity of ON01910 in the intracerebral glioma model led to the evaluation of ON013105, a prodrug of its more lipophilic anticancer congener, ON013100. A similar PK/PD approach as for ON01910.Na was applied wherein systemic pharmacokinetic properties of ON013105 and its …
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