Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Intracellular signal transduction"”.
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Control of protein adsorption, cell morphology and intracellular signal transduction using self-assembled monolayers of alkylthiolates on gold
… surface interactions at the extracellular and intracellular level. The goal of this research was to provide molecular level information on the surface determinants necessary to produce predictable, controllable biological responses to implanted materials. Various players in "outside-in" …
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Advancing multiple model-based control of complex biological systems: Applications in T cell biology
… by the T cell receptor and a vast network of intracellular signal transduction pathways, which recognize and interpret antigenic signals to determine the cell's response. The critical role of these early signaling events in normal cell function and the pathogenesis of disease ultimately make …
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G-Protein Beta3 Subunit C825T Polymorphism in Patients With Overlap Syndrome of Functional Dyspepsia and Irritable Bowel Syndrome
… beta3 subunit (GNB3) C825T polymorphism alters intracellular signal transduction, which may lead to motor or sensory abnormalities of the gastrointestinal tract. The aim of the present study was to evaluate the association of the GNB3 C825T polymorphism with susceptibility to overlap syndrome of …
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The Role of Wnt Signaling in Bone Mechanotransduction
… low bone mass. In skeletal tissue, canonical Wnt signaling is a critical regulator of bone mass, and dysregulation of the Wnt pathway has been implicated in numerous skeletal displasias. Some components of the Wnt signaling pathway have a clear role in bone homeostasis, particularly in the …
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Molecular Mechanisms Regulating Neurite Growth, Innervation and Survival
… and coordination of a diverse set of cells and signals during development and in the adult. Two important events are the regulated initiation and growth of dendrites that receive and process synaptic information, and the establishment and maintenance of appropriate neural connectivity. The goals …
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Structural and Functional Studies of Escherichia coli Kinases and Phosphatases
… Moreover, it is a ubiquitous element of intracellular signal transduction pathways that regulates a wide range of processes. While protein phosphorylation has been extensively characterized in eukaryotes, far less is known about its emerging counterparts in prokaryotes. This study …
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Engineered biomaterials as extracellular microenvironments for guiding cell programming and reprogramming
… by the cells. Cells incorporate these cues via signal propagation through integrins, and translate this information through intracellular signal transduction cascades to regulate gene expression and cell fate decisions. Advances in biomaterials to direct stem cell lineage decisions have focused …
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In Situ Regulation of Cytosolic Phospolipase A₂
… is an agonist-responsive effector for intracellular signal transduction through the arachidonate cascade.<em> In vitro</em> studies have demonstrated that this enzyme is regulated by sub-micromolar calcium and is specific for arachidonate as the sn-2 fatty acyl group of phospholipid …
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Analysis Of The Structure And Function Of A Timp-1/cd63 Complex And Its Relationship To An Mt1-Mmp/cd63 Complex
… In this area, we and others have shown important signaling cues mediated by TIMP-1 including anti-apoptotic signaling and epithelial-to-mesenchymal transition (EMT) induction; which may play a role in cancer progression. Our current research has included direct protein-protein interaction analysis …
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Novel Monte Carlo Approaches to Identify Aberrant Pathways in Cancer
… of multi-platform data to investigate signal transduction pathways within a cell. In order to model complicated dynamics and heterogeneity of biological pathways, sophisticated computational models are needed to address unique properties of both the biological hypothesis and the data. …
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Investigation on the Intracellular Sognal Transduction Mechanism of Human Dermal Fibroblasts of Photorejuvenation in Photodynamic Therapy
… skin. However, there have been no studies on the intracellular mechanism of photorejuvenation following PDT. The purpose of this study was to investigate the effects of PDT on the signal transduction mechanism in human dermal fibroblast and the role of reactive oxygen species (ROS) in vitro. …
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Neue Interaktionspartner der MAPKAP-Kinasen 3pK und MK2
… was ein funktionelles Zusammenwirken von MAPK-Signaltransduktionsnetzwerk und der Regulation der PcG-Funktion nahe legt. Ein weiterer durch das two-hybrid-System und Coimmunpräzipitationsexperimente identifizierter Interaktionspartner beider hier analysierter MAPKAP-Kinasen ist der basische …
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Influence of climate changes on cross allergies: possible involvement of pollen transglutaminase
… SAMs or psECM component, inducing possibly intracellular signal transduction during the interaction between pollen-stylar occuring in the germination process, since a protein immunorecognised by anti-FN antibody is also present in pollen, in particular at the level of pollen grain cell wall …