Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Intracellular infection"”.
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Staphylococcus aureus virulence factors dictate host signaling pathways and immune responses
… causes nosocomial- and community- acquired infections. This versatile pathogen expresses virulence factors (VF) that enhance establishment of infection and immune evasion. Our research focused on defining the roles of S. aureus VF on host immune responses during intracellular or …
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Neutrophil-Derived IFN-γ in Toxoplasma gondii Infection and Innate Immunity
… critical for host resistance to a broad range of intracellular pathogens. Production of IFN-γ by Natural Killer (NK) and T cells is initiated by the recognition of pathogens through Toll-like receptors (TLRs). In an experimental model of toxoplasmosis we have identified the presence of a …
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Reciprocal Regulation of CD4+ and CD8+ T Lymphocyte Effector and Memory Fates by Interleukin 12 and Type 1 Interferon
… (IFN-a/b) are induced to high levels by intracellular bacterial and viral infections and have been shown to promote adaptive T lymphocyte responses to infection. While the role for IL-12 on the development of T lymphocyte effector responses has been well characterized, the exact role for …
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Bacterial and host dynamics of Mycoplasma genitalium infection of the human female reporductive tract
… was available for the capacity to establish infection of the female reproductive tract and activate host immune responses. This considered, we undertook a multifaceted approach to understanding the capacity and mechanisms of MG to cause inflammatory reproductive tract disease using cell …
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Analysing M. abscessus-macrophage interactions and investigating treatments for M. abscessus and S. aureus intracellular bacterial infections, using a continuously growing, primary cell model of lung alveolar macrophages
… pathogens capable of causing a range of infections in humans, and pulmonary infections are significant amongst them. During pulmonary infection, alveolar macrophages (AMs), as sentinel immune cells of the airways, are key cells for the recognition of these invaders, and they are central …
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A Leishmania ortholog of macrophage migration inhibitory factor modulates host macrophage responses
… pathways that are important for either intracellular parasitism or for immune evasion remains to be determined. In conclusion, the presented results indicate that a Leishmania ortholog of the cytokine MIF has the ability to activate the human MIF receptor and influence the functional …
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Applying phenotypic phage selection to Chlamydia trachomatis infection
*Chlamydia trachomatis* (*Ctr*) is an obligate intracellular pathogen that causes the most common bacterial sexually transmitted infection worldwide and is the agent of trachoma, an ocular infection that is the leading cause of preventable blindness. *Ctr* has a biphasic lifecycle dependent on an …
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Modelling the interactions of Salmonellae with the human host using stem cell-derived intestinal organoids and macrophages
… predominantly flagellated, facultative intracellular bacteria, and are an important cause of enteric disease in humans and in animal hosts worldwide. Their transmission is predominantly via the faeco-oral route and members of the Salmonella enterica species can be arbitrarily classified …