Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 29 for “"Intracellular distribution"”.
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Intracellular distribution of pentobarbital sodium in rat brain
… this study was undertaken to determine the intracellular distribution of a particular barbiturate, pentobarbital sodium, within rat brain cells."--Introduction
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Intracellular distribution of nitrogen during synchronous growth of Chlorella pyrenoidosa
… nucleotide-N; DNA-N; RNA-N). The amino acid distribution within the cellular protein remained nearly constant during cellular development. Protein-N accounted for approximately 60% of the total cellular-N throughout the cell cycle. The free amino acids exhibited a variety of trends in change …
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Tissue targeting signals of Tomato leaf curl virus
The tissue and intracellular distribution of the monopartite Tomato leaf curl virus (TLCV) was investigated by in situ hybridization. contrary to the previous understanding of geminiviral localization, single stranded (SS) DNA of TCLV accumulated in the cytoplasm. TCLV ssDNA was also found in the …
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Distribution and regulation of ion channels in neurons: Quantitative studies of global ion channel transport and homeostatic synaptic scaling
… neural excitability. This thesis concerns the intracellular distribution of ion channels in the context of longitudinal transport and global neuron regulation. The principal contributions are experimental measurements, data analysis, and modeling in the study of longitudinal neurite transport. …
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Thermotherapeutic enhancement of infusate distribution during convection enhanced delivery in the brain using fiber-optic microneedle devices
… the advantages of increasing the volume of distribution (Vd) of the infusate, as well as facilitating intracellular penetration of the therapeutic. We hypothesize that heating of brain tissue will increase infusate Vd in ex vivo CED brain infusions. Methods: Formalin fixed mouse brains were …
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Intracellular Transport in Cancer Treatments: Carbon Nanohorns Conjugated to Quantum Dots and Chemotherapeutic Agents
… Nanoparticle or chemotherapeutic compound intracellular transport has implications in understanding therapeutic effect and toxicity. The scope of this thesis was to study the intracellular transport of carbon nanohorns and to improve the efficacy of various chemotherapeutic agents through …
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Potassium in young children
… defined. One reason for this is the predominant intracellular distribution of the ion and the attendant difficulties in the detection of deficiency states. Serum potassium levels are of little value as over 95% of the potassium in the body is intracellular. Balance studies and the analysis of …
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Investigation of zinc metalloneurochemistry with fluorescent sensors based on fluorescein platforms
… Fluorescein Platform: Synthesis, Properties and Intracellular Distribution Two new fluorescent sensors for Zn2' that utilize fluorescein as a reporting group, Zinpyr-1 (ZP1) and Zinpyr-2 (ZP2), have been synthesized and characterized. ZP1 is prepared in one step via a Mannich reaction, and ZP2 is …
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No-Independent Modulation of Soluble Guanylyl Cyclase (Sgc) Activity and Function
… as an NO receptor and generator of a secondary intracellular messenger, cGMP. In addition to NO, investigators have identified a number of proteins that interact with sGC and modulate its function. For example, the interaction of sGC with ADP-ribosylation factor GTPase activating protein 1 …
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AKAP12 Signalosome Regulates Cardiac β2-Adrenergic Receptor Signaling
… States. An extensive network of intertwined intracellular signaling pathways regulates cardiac remodeling (a general determinant of HF). The ability of signalosomes (molecular signaling complexes) to compartmentalize several cellular pathways has been recently established. One example of …
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PI(4)P-Dependent Recruitment of Clathrin Adaptors to the Trans-Golgi Network
… 1 (Arf1), but paradoxically, Arf1 has a broader intracellular distribution than these adaptors. We found that the Golgi is particularly enriched in phosphatidylinositol 4 phosphate [PI(4)P] and that the clathrin adaptor AP-1 binds PI(4)P directly, suggesting that PI(4)P binding may specify the …
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Lipid Targets of the Antimalarial Trioxanes in <i>Plasmodium falciparum</i>
… the endoperoxide pharmacophore underlies the intracellular distribution of trioxanes; thereby identifying cellular targets of the artemisinin-based antimalarials. We therefore identified trioxane cellular accumulation patterns within laboratory cultures of <em>P. falciparum</em> using …
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Two-Photon Microscopy of E-Combretastatin uptake and activation in live mammalian cells
… live mammalian cells, as well asmonitoring their intracellular distribution and concentration. Two-photon excitation of^-Combretastatins on monolayers of live cells led to effective conversion of the inactivepro-drugs to the highly cytotoxic Z-derivatives leading to apoptosis in the irradiated …
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Synthesis and evaluation of novel antivascular agents for two-photon activation
… cell monolayers and spheroids and their intracellular distribution. In conclusion, the two-photon excited activation of E-combretastatins on live cells was demonstrated, making these E-combretastatins promising pro-drug candidates for two photon excited anticancer phototherapy.
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An Analysis of Mitochondrial DNA in Rett Syndrome and Other Neurodegenerative Disorders
… lymphoblasts and identified an intercellular distribution of mutant and normal mtDNA. This differs from analyses performed in LHON and MERRF (myoclonic epilepsy, ragged red fibers) pedigrees which demonstrate a predominantly intracellular distribution. This may implicate MELAS as a …
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REEP5-MFN1/2 tethering in ER-mitochondria crosstalk
… ER and plays a critical role in regulating the intracellular distribution of mitochondria. Results demonstrated that attenuated interactions between REEP5 and MFN1/2 lead to the collapse of mitochondrial networks and perinucleus clustering. Conversely, enhanced interactions between REEP5 and …
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Recombinant DDX58 associates with SOD1 protein and selective miRNA changes in secreted EVs
… control exerted by RNA-binding proteins at intracellular level. Here, we studied a novel EV-associated function for DExD/H-Box Helicase 58 (DDX58) RNA-binding protein, also known as RIG-I (retinoic acid inducible gene I). DDX58 is a cytosolic RNA sensor involved in innate immunity against …
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The impact of advanced maternal age on endometrial differentiation and placental development
… insufficient activation levels and abnormal intracellular distribution of phospho-STAT3, combined with highly variable progesterone receptor expression, may be possible causes of these defects. In addition, I examined the possible effects of ageing on the epigenome as a potential contributor …
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Expression and Functional Analysis of Hepatitis B Virus DNA Polymerase
… of chimeric polymerases were not detected. The distribution of HBV polyemerase was exclusively localized in cytoplasm and little co-localized between HBV polymerase and the organelles markers such as endoplasmic reticulum, Golgi and peroxisome. When the several chimeric constructs and polymerase …
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Therapeutic targeting of the ATP7A copper transporter in cancer
… this, cells have evolved to control Cu uptake, intracellular distribution, and export. The high-affinity Cu transporter 1 (CTR1) mediates cellular Cu uptake, while the P1B-type ATPase ATP7A facilitates Cu transport from the cytosol into the lumen of vesicles or the trans-Golgi network (TGN), …
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