Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"Intracellular Signals"”.
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A dynamical model of the distributed interaction of intracellular signals
A major goal of modern cell biology is to understand the regulation of cell behavior in the reductive terms of all the molecular interactions. This aim is made explicit by the assertion that understanding a cell's response to stimuli requires a full inventory of details. Currently, no satisfactory …
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Rutas de señalización intracelular que regulan la apoptosis inducida por lovastatina en neuroblastos fetales de rata
The aim of this Thesis has been to study the intracellular signals and molecular mechanisms that control neuronal apoptosis. We have mainly focused our attention to the survival pathways Duch as RAS/RAF/MAP-kinases, PI3-K/PKB, as well as death pathways, stress-activated MAP-kinases (JUN-kinases and …
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Cytokine engineering through ligand/receptor dynamics : a study on granulocyte colony-simulating factor
… on bone marrow precursor cells and generates intracellular signals that cause these cells to proliferate and differentiate into mature neutrophils. However, for such cytokines that act as agonists for cell-surface receptors, these complexes undergo trafficking processes that often attenuate …
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MODELING, ANALYSIS, AND CONTROL OF SYK-MEDIATED SIGNALING EVENTS FOR B CELLS AND ASSOCIATED CELLULAR RESPONSE FOR B CELLS
… responses, and chemicals responsible for intracellular and intercellular communication. The overall immune response is driven by individual actions of neutrophils, antigen-presenting cells, and lymphocytes (T cells and B cells), among other cells. Intercellular communication is the means …
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Functional relationships among lck kinase and the lat and grb2 adaptors in the intracellular signaling cascade of the tcr/cd3 complex: implications in thymic development and lymphocyte activation
… which upon activation triggers a very complex intracellular signaling. Failures in these intracellular signals can lead to the loss of tolerance or to the development of deficient T lymphocytes. In this work, we attempt to address the role of two essential proteins in early TCR signaling, the …
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Investigations into the chemistry of protein tyrosine phosphatase redox regulation
Transmission of complex intracellular signals, such as those for glucose uptake or proliferation, is often accomplished through the reversible phosphorylation of specific protein tyrosine residues. This reversible phosphorylation serves as a biochemical "rheostat" that alters a protein's functional …
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Dissection of spatiotemporal intracellular signaling using engineered chemical and genetic tools
… proteins are responsible for transmitting intracellular signals and enacting the appropriate response to received stimuli. These messages are propagated through networks that rely on allosteric regulation, post-translational modifications, or other mechanisms for modulating signaling …
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Cue, signal, response analysis of murine embryonic stem cell differentiation : multivariable analysis of cytokine and ECM effects on commitment to differentiation
… to generalize broadly or discern determinative signals from. Here we offer a combined experimental/computational investigation aimed at elucidating in a systematic manner important synergies between multiple extracellular cues, especially from cytokines and matrix proteins together, and …
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Zeta-Ketten Expression bei Patienten mit SCCHN und dendritische Zellen als Stimulatoren für T-Zellen In Vitro
… (TCR) is involved in the transduction of intracellular signals and is therefore critical for T cell activation and subsequent induction of an anti-tumor response. In patients with squamous cell carcinoma of the head and neck (SCCHN) several mechanisms of immune suppression have been …
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Overcoming the biological barriers to intravenous delivery of stem cells and drugs for the treatment of vascular-related diseases
… By incorporating moieties sensitive to the intracellular signals of cancer cells, drug release from the particles was significantly accelerated, giving rise to superior in vivo antitumor efficacy. Ultimately, the results of this dissertation will greatly contribute to improving the …
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NK Cell Function and Tumor Resistance in Mice Transgenic for Antibody to NK Inhibitory Receptors
… cell. This allows the transmission of inhibitory signals through intracellular signals to block NK cytotoxicity. Many tumors express sufficient levels of self MHC class I and are able to escape lysis by NK cells. Our lab has been studying the inhibitory regulatory pathways in natural killer cells …
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The Role of EGFR Signaling in Gonadotropin-Induced Steroidogenesis
… tissues. We have recently characterized the intracellular signals regulating Luteinizing Hormone (LH) -induced steroid production in Leydig cells, demonstrating a linear pathway whereby LH receptor activation stimulates cAMP production and PKA signaling. Protein Kinase A (PKA) signaling then …
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Synthetic Peptide Ligand Mimetics and Tumor Cell Motility
… subunits and elevates laminin-5 dependent intracellular signals including focal adhesion kinase, mitogen activated protein kinase kinase, and extracellular signal-regulated kinase. The scrambled derivative of HYD1, HYDS, does not interact with the a6 or a3 integrin subunits and is not …
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Visualization of cellular signaling by fluorescence resonance energy transfer in response to biochemical and mechanical microenvironments
… their behavior. Hence, visualization of the intracellular signals is a challenge of major importance for in-depth understanding of the relationship between biochemical/mechanical cues and various cellular responses. In this thesis, I have focused on Ca2+, cAMP-dependent protein kinas A (PKA), …
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Structural and Functional Studies of SLO K+ Channels: Mechanisms of Gating by Intracellular Signaling
… (SLO1, SLO2 and SLO3) provide a link between intracellular signaling and the electrical activity of a cell. The opening and closing (gating) of the three different SLO homologs is controlled by the synergistic action of membrane voltage and specific intracellular cues: Ca<sup>2+</sup> binding …
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The differential Role of Insulin-like Growth Factor-1 Isoforms in Skeletal muscle
… in the hypertrophic response. Analysis of the intracellular signals transduced by the different IGF-1 isoforms revealed a complex regulatory network, excluding certain pathways previously implicated in the induction of skeletal muscle hypertrophy in response to IGF-1. Preliminary analysis of …
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Investigating the Role of the IP₃ Signalling Pathway in RNA Interference in C. elegans
… is a key second messenger in the transduction of intracellular signals. Produced by the hydrolysis of membrane phospholipid PIP₂ by phospholipase C (PLC), IP₃ triggers Ca²⁺ release from internal stores by binding to the IP₃ receptor, a ligand gated calcium channel in the ER, thus triggering …
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Molecular mechanisms of mammalian cell survival and differentiation
… processes are regulated by extracellular and intracellular signals that are mediated by networks of signaling pathways. In recent years, microRNAs have also emerged as a class of critical modulators of the same processes. For my thesis studies, I focused on regulatory mechanisms underlying …
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REGULATION OF GLYCOSYLATION IN MAMMALIAN CELL LINES: INSIGHTS FROM STRUCTURAL GLYCOMICS, ANALYSIS OF GLYCOSYLATION-RELATED GENES AND FUNCTIONAL RNAI SCREENS
… pathway in response to extracellular or intracellular signals. In summary, this multi-layered investigation provides a set of essential information for selection of cell lines for biotech application as well as promising molecular targets for controlling the glycosylation for enhancing …
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Molecular and Cellular Mechanisms of LIM Protein Mechanotransduction
… convert mechanical stimuli into biochemical signals (mechanotransduction) are poorly understood. The actin cytoskeleton serves as a nexus for cellular mechanotransduction, generating and transducing forces into intracellular signals that coordinate cell migration, cellular contractility, …
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