Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 14 of 14 for “"Intracellular Signaling Peptides and Proteins"”.
-
Calpain 9 Functions in TNF Receptor Mediated Apoptosis
… cancer development. The Inhibitor of Apoptosis Proteins, IAPs, block Caspase activity and cell death. Release of the Second Mitochondria-Derived Activator of Caspases, Smac, from the mitochondria relieves IAP Caspase inhibition, activating apoptosis. Our lab has developed a small molecule Smac …
-
Orexin Signaling and the Prevention of Diet-Induced Obesity
… appetite, yet orexin deficiency in humans and mice is associated with obesity. Prolonged effects of orexin signaling upon energy homeostasis have not been fully characterized. In this study, I utilized both genetic and pharmacologic approaches to characterize metabolic effects of orexin …
-
Detection of Polypeptide Interactions Via Periodate Triggered Dopa Crosslinking
… interactions between the 26S proteasome and activation domains as well as the Arp 2/3 complex and the CA peptide. Finally, we present the creation of a chimeric molecule consisting of the biarsencial fluorescent reporter FLAsH conjugated to 3,4-Dihydroxyphenylalanine as a route to deliver …
-
SCAP, Insig, and Cholesterol Interactions in Mammalian Cells
… of genes necessary for both fatty acid and cholesterol production are controlled by sterol regulatory element binding proteins (SREBPs). The critical regulatory step is the proteolytic release of SREBPs from their inactive membrane bound form. Soon after translation, SREBPs bind SREBP …
-
The Intracellular Domain of EPHB1 Is Required for Axon Pathfinding at the Optic Chiasm and Corpus Callosum
… evidence of the importance of EphB1 mediated signaling in retinal and callosal axons while attempting to reach their targets. EphB receptor tyrosine kinases direct axonal pathfinding through interactions with ephrin-B proteins following axon-cell contact. Since EphB:ephrin-B binding leads to …
-
Delineating the Role of CD244 in NK Cell Cytotoxicity and the Contribution of Ly108 to Thymocyte Development
… (Ly9), CS-1 (CRACC), CD48 CD150 (SLAM), CD84, and Ly108 (NTB-A)) as causative for a breach in tolerance of both T and B cells leading to the production of self reactive antibodies. Analysis of common strains of laboratory mice revealed the existence of two stable haplotypes (b and z) of the …
-
Modalities of Cholesterol Binding and Modulation of the NPC Proteins and Scap
Low density lipoproteins (LDL) and related plasma lipoproteins deliver cholesterol to cells by receptor-mediated endocytosis. The lipoprotein is degraded in late endosomes and lysosomes, allowing cholesterol to be released. Export of cholesterol from late endosomes and lysosomes (hereafter referred …
-
Evolutionary Constraints Specifying Protein Folding and Function
Proteins are complex macromolecules that carry out biological functions while under constant mutational load and selective pressure during evolution. Consequently, evolution has generated protein families by exploring the set of sequences able to carry out a particular biological activity, …
-
Blood Vessel Development
… developing functional organ in vertebrates, and one of the fundamental organ systems through adulthoods. Cardiovascular function depends on patent blood vessel formation by endothelial cells. In this dissertation, a careful analysis of different aspects of blood vessel development was …
-
The Hippo Signaling Pathway in Organ Size Control and Regeneraton
The Hippo (Hpo) signaling pathway controls cell growth, proliferation and apoptosis in both Drosophila and vertebrates. Our lab has previously demonstrated that Hpo signaling regulates gene expression by inhibiting a transcription complex consisting of the transcriptional coactivator Yorkie (Yki) …
-
Utilizing Drosophila S2 Cells as a Model System to Determine Underlying Mechanisms of ER-associated Degradation
Proper folding of nascent polypeptides is vital to maintain cellular homeostasis; proteins that adopt aberrant confirmations are selectively degraded through a multi-step process known as endoplasmic reticulum-associated degradation (ERAD). Underlying mechanisms for ERAD of membrane proteins, …
-
A Chemically Induced Colitis Screen Reveals the Necessity for Membrane Traffic in Intestinal Homeostasis
… caused by the interaction of environmental and genetic aberrations. Under normal conditions, a genetic program actively prevents inflammatory bowel disease, preventing invasion of microbes without permitting severe inflammation of the gut. To identify genes that maintain this balance, we …
-
STK25 and TAO Regulate Muscle-Specific Transcription and Muscle Function in the Parasitic Flatworm Schistosoma Mansoni
… regions, including large parts of Africa, Asia, and South America. In some of these areas, the disease affects over 50% of the population, making Schistosomiasis second only to Malaria in parasite devastation. To look for functionally important schistosome genes, we performed a large-scale RNAi …
-
Regulation of the cGAS-STING Pathway in Health and Disease
Pages v-xiii are misnumbered as pages vi-xiv.