Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 111 for “"Intracellular Ca2+"”.
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Signalling to intracellular Ca2+ channels
… to sustained (60 min) stimulation. However, intracellular concentrations of cAMP were greater after sustained stimulation. Inhibition of protein kinase A (PKA) or exchange proteins activated by cAMP (EPAC) had no effect on the Ca$^{2+}$ signals evoked by carbachol after acute or sustained …
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Analysis of intracellular Ca2+ oscillations in a neuroendocrine cell
Contains fulltext : 147080.pdf (Publisher’s version ) (Open Access)
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The role of intracellular Ca2+ in the arrhythmogenic activity of pulmonary vein cardiomyocytes
… underlying mechanisms are unknown. Changes in intracellular Ca2+ signalling have been proposed to play an important role in the arrhythmogenic properties of the pulmonary vein. Therefore, the aim of this thesis was to study factors that might influence Ca2+ signalling in the cardiomyocytes. …
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Myocardial force and intracellular Ca2+ in an animal model of hypertensive heart failure
… was to investigate the relationship between intracellular calcium ([Ca2+]i) and isometric force during the relatively narrow time frame in which long-standing compensated hypertrophy progresses to decompensated end-stage heart failure in an animal model of human essential hypertension. In …
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TRP channels and a dextran sulfate activated rise in intracellular Ca2+ and Na+ in a subpopulation of double positive thymocytes
… the characteristics of the sustained rise of intracellular Ca2+ ([Ca2+]i) and Na+ ([Na+]i), observed in pre-selection CD4+CD8+ (double-positive, DP) thymocytes when stimulated with dextran sulfate (DxS) and explores several candidate channels that may be involved in this rise. . This [Ca2+]i …
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TRP channels and a dextran sulfate activated rise in intracellular Ca2+ and Na+ in a subpopulation of double positive thymocytes
… the characteristics of the sustained rise of intracellular Ca2+ ([Ca2+]i) and Na+ ([Na+]i), observed in pre-selection CD4+CD8+ (double-positive, DP) thymocytes when stimulated with dextran sulfate (DxS) and explores several candidate channels that may be involved in this rise. . This [Ca2+]i …
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Modulation of neuronal ryanodine receptor-mediated calcium signaling by calsenilin
Calsenilin is calcium (Ca2+) ion Ca2+ binding protein found in the nucleus, plasma membrane, and endoplasmic reticulum of neuronal cells. Calsenilin was first found to interact with two proteins involved in early-onset familial Alzheimer disease (AD), presenilin 1 and presenilin 2. Several studies …
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Coronary artery disease in metabolic syndrome: a role for the sarcoplasmic reticulum Ca2+ ATPase
… for the first time the time course of Ca2+ dysregulation during MetS-induced CAD progression. In particular, we used the fluorescent Ca2+ dye, fura-2, to examine alterations in CSM intracellular Ca2+ regulation during CAD progression, as perturbations in intracellular Ca2+ regulation …
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Reactive Oxygen Species-Induced Necrotic Cell Death
… adenine dinucleotide (NAD), elevations in intracellular Ca2+ concentrations, loss of mitochondrial membrane potential, and subsequent necrotic cell death. Interestingly, PARP-1 hyperactivation was not accompanied by the translocation of apoptosis-inducing factor (AIF) from mitochondria to …
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Morphological responses of neutrophils in suspension to plasma components and chemotactic factors / Damien Gerard Harkin.
… roles of extracellular divalent cations (Ca2+ and Mg2+), intracellular Ca2+ ions and actin microfilament distribution during responses to each stimulus are examined.
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Investigation of the role of Staphylococcus Aureus toxins in a cartilage explant model of septic arthritis
… culture medium osmolarity and extracellular Ca2+ on Hla-induced in situ chondrocyte death; and (4) dynamic changes in intracellular Ca2+ within in situ chondrocytes following Hla exposure. S. aureus 8325-4 and S. aureus clinical strains rapidly reduced in situ chondrocyte viability (>45% …
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A pharmacological study of signal transduction mechanisms controlling fluid reabsorption and Ion transport in the locust rectum
… both Cl- and fluid reabsorption. External Ca2+ was not required for the maintenance or stimulation of rectal transport. However, intracellular Ca2+ was shown to influence the control of rectal transport. The role of intracellular Ca2+ appears to be quite complex and may vary with its …
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Cholinergic Regulation of Circadian Rhythms in the SCN: Characterization of Signaling Mechanisms and the Role of Intracellular Calcium in the Directionality of Clock Resetting
This study shows that stimulus-specific intracellular Ca2+ (Ca2+i) release controls the direction of clock resetting. Direct activation of the InsP3-induced Ca2+ i release (IICR) mimics cholinergic phase advance, while InsP3 , but not ryanodine, receptor antagonists block it. In contrast, selective …
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Assessing the Role of the Transient Receptor Potential Melastatin 3 (TRPM3) Ion Channel in Visceral Sensation
… pain. I utilized immunohistochemistry, Ca2+ imaging, and afferent nerve recording to evaluate TRPM3 protein expression in colon-projecting dorsal root ganglion (DRG) neurons and colonic nerve terminals, as well as functional activity at the neuronal and nerve levels. TRPM3 protein …
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Angiotensin Type-2 (At2) Receptor Modulation of Nmda-Mediated Current, Signaling and Apoptosis
… subunit phosphorylation and current to decrease intracellular Ca2+ levels and subsequent downstream signaling. Taken together these results characterize a novel mechanism for describing the AT2 receptor's neuroprotective functions.
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Impaired metabolism in X-linked muscular dystrophy: experimental evaluation of potential therapies to improve calcium regulation, bioenergetics and muscle architecture
… muscle wasting disease characterised by [Ca2+]-induced hyper-catabolism, and subsequently, a higher demand for energy production to modulate intracellular Ca2+ homeostasis, and protein degradation and synthesis pathways. The broad aim of this thesis was to elucidate potential defects in …
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Regulation of Transglutaminase by 5-HT2A Receptor Signaling and Calmodulin
… (IP3) and diacyglycerol. IP3 mobilizes Ca2+ from the endoplasmic reticulum and thereby increases intracellular Ca2+ and consequently, it may enhance TGases enzymatic activity. Inhibition of PLC or manipulation of intracellular Ca2+ by a chelating agent suppressed 5-HT2A receptor-mediated …
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The role of extracellular matrix in modulation of myocyte Ca2+ signalling and contraction in the isolated rat heart
… it was observed that the amplitude of the intracellular Ca2+ transients that underlie contraction was reduced in isolated myocytes in comparison to Ca2+ transients from multicellular trabeculae. The role of ECM in myocyte Ca2+ modulation is poorly understood. We therefore hypothesised that …
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Towards an understanding of the role of Ca2+ signalling in neural stem cell activation
… activation. Since Slo is a negative regulator of Ca2+ signalling, I investigated Ca2+ levels in quiescent and active NSCs. I have found that quiescent NSCs have significantly higher intracellular Ca2+ compared to active NSCs. Upregulation of intracellular Ca2+ phenocopies loss of Slo, repressing …
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Pharmacological Studies of the Signal Transduction Pathways of the a 1a-Adrenbrgic Receptor Subtype
… activation by norepinephrine increased cytosolic Ca2+ concentration and phosphorylated ERR 1/2 in a time- and concentration-dependent manner. ERR 1/2 phosphorylation was blocked by the MAPR kinase (MER1/2) inhibitor, PD98059, and the a1-AR antagonist, prazosin. A transient elevation in …
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