Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 9 of 9 for “"Intra-tumour heterogeneity"”.
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The Intra-Tumour Heterogeneity Landscape of Human Cancers
Tumours accumulate many somatic mutations in their lifetime. Some of these mutations, drivers, convey a selective advantage and can induce clonal expansions. Incomplete clonal expansions give rise to intra-tumour heterogeneity. Somatic mutations can be measured through massively parallel …
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Evaluations and Consequences of Tumour Evolution
… lineage, resulting in varying degrees of intra-tumour heterogeneity. Thus, the cancer genome encodes part of the evolutionary history of the tumour. Studying tumour evolution sheds light on the diversity of evolutionary paths to invasive disease and addresses challenges in cancer clinical …
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Inferring tumour evolution from single-cell and multi-sample data
Tumour development has long been recognised as an evolutionary process during which cells accumulate mutations and evolve into a mix of genetically distinct cell subpopulations. The resulting genetic intra-tumour heterogeneity poses a major challenge to cancer therapy, as it increases the chance of …
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Preclinical Modelling of Breast Cancer Drug Responses
… disease, exhibiting both inter- and intra- tumour heterogeneity at genomic and phenotypic levels. This remains a key limitation in the treatment of the disease. While recent advances have dramatically improved our understanding and treatment strategies for specific subgroups of …
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Clonal Dynamics in Barrett's Oesophagus and Oesophageal Adenocarcinoma
… known to be highly heterogeneous, but while this heterogeneity has been well studied for IM, little is known about the clonal dynamics in GM and OAC. Clonal dynamics can be explored through longitudinal or multi-sample genomic studies, or experimentally. There is no physiologically relevant in …
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Decoding the regulatory role and epiclonal dynamics of DNA methylation in 1482 breast tumours
… protocol was performed on 1482 primary breast tumours (and 237 matched adjacent normal tissues). This constitutes the largest breast cancer methylome yet, and this thesis describes the bioinformatics and statistical analysis of this study. Noticeable epigenetic drift (both gain and loss of …
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Resolving the evolution of Oesophageal Adenocarcinoma using spatial and temporal sampling
… the US guidelines. Furthermore, the considerable intra-tumour heterogeneity (ITH) may underlie the observed chemo-resistance. There have not been any large-scale studies to assess ITH in OAC and associated BO. Aside from multi-region sequencing, another way of overcoming sampling bias of the …
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Prostate cancer evolution employing artificial intelligence to enhance biomarker discovery
… with phenotypically and genetically distinct tumour foci. Additionally, cellular heterogeneity has the ability to harbour phenotypically diverse cancer cell types. Prostate cancer needs to be explored across different levels to enhance our understanding of disease progression. This can be …
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Characterising the evolutionary dynamics of hypermutated tumours using single-cell sequencing
… to a high burden of neoantigens and increased tumour immunogenicity. As a result, hypermutated cancers show the highest response rates to immune checkpoint blockade (ICB), a type of immunotherapy that has revolutionised the treatment landscape for multiple cancer types. Yet, durable responses …