Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 10 of 10 for “"Intra-tumor Heterogeneity"”.
-
Intra-tumor heterogeneity and evolution
… many cancers are extremely hard to treat. Tumors likely resist treatment because each tumor is heterogeneous, and can evolve. Although tumor evolution has long been appreciated, it remains incompletely understood. In this thesis, I will explore two questions related to cancer heterogeneity …
-
Deciphering the heterogeneity and spatial architecture of tumors
… of cells, called clones. The resulting intra-tumor heterogeneity evolves temporally, as well as spatially, and is the main cause of relapse and resistance to treatment. With decreasing costs in DNA sequencing technology, rich cancer genomics datasets that effectively capture mutational …
-
Using Tissue Morphology to Infer Intra-Tumor Variation in Molecular State and Response
Intra-tumor heterogeneity (ITH) presents a significant challenge in the effective treatment of cancer. The traditional approaches to characterize ITH, such as multi-regional sequencing, are cost prohibitive for broad adoption. In contrast, histopathology slides are ubiquitous and, as evidenced by …
-
INTEGRATED SINGLE-CELL MUTATION, GENE EXPRESSION AND ISOFORM ANALYSIS TO DECONVOLVE ACUTE MYELOID LEUKEMIA HETEROGENEITY
… from the hematopoietic stem cell (HSC). As other tumor types, AMLs are characterized by multiple and interconnected levels of intra-tumor heterogeneity, including genetic (DNA mutations), phenotypic (transcriptional patterns) and ecological (interactions with host immune-cells) diversity. Emerging …
-
Applying multi-omics to detect indolent and aggressive early-stage lung adenocarcinoma
… grade. Second, to assess molecular and tumor microenvironment features associated with the VI subtype we analyzed resected stage I tumors (n=163) with and without VI by RNA sequencing, including 15 samples by high-resolution spatial transcriptomics. Interestingly, gene expression …
-
Decoding Treatment Resistance and Genotype-Phenotype Interactions at Single Cell Resolution
<p>Understanding how cancer cells and their tumor microenvironment (TME) mediate chemoradiation (CRT) resistance in esophageal adenocarcinoma (EAC) is key for improving the low treatment response rate in the clinic. Here, we generated single cell transcriptomics data of 302,035 cells from N=83 …
-
Quantifying and summarizing tumor phylogeny solution spaces
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2026-08-01
-
Developing Targeted Therapies for T-cell Acute Lymphoblastic Leukemia
… often occurs during leukemogenesis, resulting in heterogeneity in the leukemia cell population and affecting dasatinib response. Therefore, we tested these hypotheses: 1) a subset of T-ALL cases responds to dasatinib in an ABL1-independent manner; 2) dasatinib sensitivity in T-ALL is associated …
-
Integrative Analysis of Omics Data In Adult Glioma and Other Tcga Cancers to Guide Precision Medicine
… plasticity and its association with the tumor microenvironment in glioblastoma (GBM). I have integrated transcriptomic, genomic, protein and clinical data to increase the accuracy of GBM classification, and identify the association between the GBM mesenchymal subtype and reduced …
-
Algorithms for genomic variant identification and interpretation
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2025-05-01