Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"Intimal hyperplasia"”.
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The compounding effects of obesity on the development of Intimal Hyperplasia following vascular intervention : a histopathological analysis
This study examines the histopathological response to injury following both balloon angioplasty and endovascular stenting in the Zucker rat, a model that allows interpretation of the role of obesity as well as progressive glucose intolerance and hyperinsulimaemia. Lean and obese Zucker fatty rats …
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Granulocyte Colony-Stimulating Factor Minimizes Negative Remodeling of Decellularized Small Diameter Vascular Graft Conduits but Not Medial Degeneration
BACKGROUND: Poor endothelialization and intimal hyperplasia are major causes of small diameter vascular conduit (SDVC) failure. The present study was aimed to investigate the influence of granulocyte colony-stimulating factor (G-CSF) on inhibiting adverse remodeling of decellularized SDVCs. …
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FUNCTIONALIZATION OF A NOVEL ELASTOMERIC BIOMATERIAL FOR VASCULAR TISSUE ENGINEERING
… (< 6 mm) coronary arteries, but is subject to intimal hyperplasia, thrombosis, and accelerated atherosclerosis. To date, no biomaterial functions as a substitute for autologous vein graft. A novel composite material composed of electrospun poly(glycerol sebacate), silk fibroin, and type I …
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Expression, Purification, And Characterization Of Elastin-Like Polypeptides Containing Chondroitin Sulphate Binding Domains
… number of factors including thrombus formation, intimal hyperplasia, and infection. Intimal hyperplasia, of particular interest in this study, involves the build up of smooth muscle cells (SMCs) in the intimal layer of the artery due to abnormal migration and proliferation. This work focuses on …
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RHAMM Alters Vascular Smooth Muscle Cell Constrictive Matrix Remodeling
… been met with very high rates of late failures. Intimal hyperplasia and constrictive remodeling are the two primary structural mechanisms that lead to restenosis. Constrictive remodeling refers to artery wall shrinkage independent of new wall mass formation after arterial intervention. The …
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Novel Treatment of Anal Fistulas and Endovascular Drug Delivery for Peripheral Arterial Disease
… experience recurrence. The cause of this is intimal hyperplasia. The drug Amlexanox has been shown to reduce intimal hyperplasia in dogs. In this study we propose a stretch-release drug delivery platform for delivering Amlexanox. This platform consists of a cyclodextrin acrylamide gel coating …
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Fluid Dynamic Assessments of Spiral Flow Induced by Vascular Grafts
… end stage renal disease. The development of neo-intimal hyperplasia and thrombosis in the distal anastomosis remains the main reason for occlusion in that region. The local haemodynamics produced by a graft in the host vessel is believed to significantly affect endothelial function. Single spiral …
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Hyaluronic acid enhancement of expanded polytetrafluoroethylene for small diameter vascular grafts
… display failure due to early thrombosis or late intimal hyperplasia. With the shortage of tissue donors and the limited supply of autologous blood vessels available, there is a need for a small diameter synthetic vascular graft alternative. The aim of this research is to create and characterize …
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Regulations and functions of P2Y₂ and P2X₇ nucleotide receptors in the central nervous system
… the involvement of P2Y₂Rs in the development of intimal hyperplasia. Based on these studies, particular emphasis was placed on delineating the role of the P2Y₂ receptor subtype in neuronal inflammation and the P2X₇ receptor subtype in neuronal apoptosis in the central nervous system. In the rat …
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Distant hemodynamic impact of local geometric alterations in the arterial tree
… as reflected by a reduction in in-stent neo-intimal hyperplasia.
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Leukocyte Response to Elastin-Like Polypeptide Coatings
… due to luminal narrowing from thrombosis and intimal hyperplasia. Current attempts to address this issue include the development of materials that support endothelialisation and protein modification to the material surfaces that reduce thrombosis. The extracellular matrix protein elastin has …
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A patient-specific FSI model for vascular access in haemodialysis
… flow circulation are identified as areas where intimal hyperplasia may develop. The flow results from the simulation show good qualitative agreement with the MRI data.
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DRUG ELUTING TISSUE ENGINEERED VASCULAR GRAFTS
… of restenosis secondary to a phenomenon called Intimal Hyperplasia (IH). We have performed previous animal studies using 2mm TEVG in rabbits and 5mm TEVG in sheep which had restenosis rates secondary to IH of 70% and 60% respectively. IH is secondary to an inflammatory response after …
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Investigating the Role of Phosphodiesterase 1C in Vascular Smooth Muscle Cell Migration and Invasion
… while several cAMP-elevating agents reduce intimal hyperplasia/hypertrophy in animal models, it is presently unclear whether these effects are due to reduced matrix invasion of these cells or solely to inhibition of their migratory capacity. Previous work conducted by our group and others …
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Polo-Like Kinase 1 and Smooth Muscle Cells in Coronary Artery Bypass Conduits and Coronary Arteries Following Angioplasty
… internal mammary artery (IMA) graft is immune to intimal hyperplasia (IH) whereas a saphenous vein (SV) graft is prone to undergo restenosis due to neointima formation. However, the underlying mechanism in vein-graft that makes it prone to stenosis and closure is unknown. In this study, we …
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Synthesis, evaluation, and applications of hydrogen sulfide-releasing supramolecular materials
… releasing H2S locally to test its efficacy on intimal hyperplasia. The hydrogel delivered H2S over the period of several hours and inhibited the proliferation of human vascular smooth muscle cells (VSMCs) significantly better than fast-releasing NaSH salts. This study shows a promising …
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Effect of laminar shear stress on gene regulation, protein synthesis, and protein secretion by cultured human endothelial cells
… vessel bifurcations and; (2) the severity of intimal hyperplasia in surgical vein bypass grafts and vessel anastomotic sites.
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Cyclic stretch-mediated release of vascular endothelial growth factor by vascular smooth muscle cells : a role in improved vascular graft patency
… endothelial cell mediation, will not result in intimal hyperplasia but rather play a role in microvessel maintenance and more complete healing.
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Isolating and optimising transmural endothelialization as an independent mode of spontaneous vascular graft healing
… 12 and 24 (95.0±10.0% and 84.0±30.13%). The subintimal thickness did not increase (91.8±93.9 mm vs. 71.4±59.4 mm at 6 and 24 weeks, respectively; NS). All sealed grafts occluded. Mid-graft endothelialization was not influenced by 50µmFilmwrap (93±8.3%), but the 350µm-Wrap significantly reduced …
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