Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 78 for “"Intestinal microbiota"”.
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The Role of the Intestinal Microbiota in Inflammatory Bowel Disease
… environmental, and microbial factors. The intestinal microbiota is crucial for IBD induction and complex shifts in microbiota composition occur in IBD, but disease has not been consistently associated with presence or absence of a specific microbe. It is thus controversial whether …
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Human intestinal microbiota and metabolites they produce in relation to host health
The aim of this thesis was to identify selected potential probiotic characteristics of Bifidobacterium longum strains isolated from human sources, and to examine these characteristics in detail using genomic and phenotypic techniques. One strain in particular Bifidobacterium longum DPC 6315 was the …
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Bacterial Mucolysis, Inflammatory Mucogenesis and the Stability of Host-Intestinal Microbiota Interactions
… dissertation addressed the balance between the intestinal microbial ecology and the host. Moreover, the intestinal mucosal barrier serves as an important and necessary mediator of host-microbe interactions. Due to the exquisite sensitivity of this complex system, disruptions to the microbiota, …
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The upper small intestinal microbiota regulates nutrient sensing pathways to influence glucose homeostasis
… by a dysregulation in glucose homeostasis. The microbiota within the gastrointestinal tract has been suggested to play a role in glucose regulation. However, the majority of work to date has focused on the distal intestinal microbiota despite the fact that the upper small intestine has immense …
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Alterations in preconception, antenatal, and postnatal maternal gut microbiota influence offspring intestinal microbiota and immunity
Maternal microbiota during pregnancy, as well as maternal disease state, may impact offspring gut bacterial colonisation. Here, we explore the impact of maternal antibiotics during gestation and/or nursing on offspring gut microbiota. Further, we investigate the effect of preconception helminth …
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Evaluation of Different Probiotic Strains Supplemented in Commercial Broiler Rations and their Influences on Performance, Yield, and Intestinal Microbiota.
… and their influences on performance, yield, and intestinal microbiota. This trial was completed as a randomized-block design with 4,800 birds split into 96, 5’x10’ pens, and randomly assigned to one of eight treatment groups. The birds were placed at a stocking density of 1.00 …
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Pre-, pro-, and synbiotic modulation of the intestinal microbiota stimulates enteroendocrine mediated intestinal adaptation in piglets with short-bowel syndrome
… an ill-defined etiology that is associated with intestinal microbial dysbiosis, defined by altered intestinal microbiota, decreased bacterial diversity, and antibiotic use. SBS is associated with an enteroendocrine cascade beginning with intestinal secretion of glucagon-like peptide-2 (GLP-2), an …
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REGULATION OF T CELLS AND TISSUE INFLAMMATION BY SHORT CHAIN FATTY ACIDS
Intestinal microbiota regulate various biological processes in the host. Intestinal microbiota produce short chain fatty acids (SCFAs) via dietary fiber fermentation. SCFAs have profound effects on the immune system. We investigated the roles of SCFAs in regulating T cell differentiation and tissue …
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Modulation of Obesity and its Sequelae by Microbiome/Immune System Interactions
<p>The intestinal microbiota have been proposed as one of the causally contributing factors to the current obesity pandemic. A dearth of safe and effective approaches to the therapy of obesity points to the need for clearer definition of the mechanisms underlying the development of obesity and its …
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Investigating dysbiosis as a cause and predictor of intestinal pathology
Intestinal dysbiosis involves a shift in microbial composition and abundance within the gut and compelling evidence has highlighted the pivotal role dysbiosis plays in the onset and pathogenesis of numerous diseases, including inflammatory bowel disease (IBD), allergies and even mental health …
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Regulation of Autoimmunity and Inflammation by microRNAs and Environmental Factors
… Study III, we investigated whether the maternal intestinal microbiota is an environmental factor influencing T1D development in the offspring. By modulating the intestinal gut microbiota with antibiotics during pregnancy of NOD mice we showed decreased diversity and a persistent modulation of the …
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The role of host and microbial factors in the pathogenesis of chronic schistosomiasis in mice
… tripartite interplays between the commensal microbiota, host's genetic factors, and immune response during helminth infections which are still poorly understood. The study explores this relationship in the context of chronic schistosomiasis-driven pathology. In the first part of the thesis, …
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Molecular characterisation of selected gastrointestinal microbiota in South African HIV-positive patients during HAART
… diarrhoea due to the disruption of the gastrointestinal microbiota caused by either the HIV-infection or the use of antibiotics and drugs such as highly active antiretroviral therapy (HAART). An imbalance in the microbial composition, attributable to a disturbed mucosal barrier, as well as …
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Influencia del estrés materno prenatal sobre la composición y estructura de la microbiota intestinal infantil
… and babies development, focusing on the infant intestinal microbiota and health, besides being a potential for bacterial interventions to improve the health and development of the offspring in pregnant women with stress.
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Effect of chia (Salvia hispanica l.) on the bioavailability of minerals, lipid profile, inflammation, oxidative stress, and intestinal health
… from chia on the morphology and functionality intestinal, on intestinal microbiota and on iron and zinc status are not known. In this sense, the objective of the study was to evaluate the effect of chia (Salvia hispanica L.) flour consumption on the bioavailability of calcium, iron and zinc, …
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Non-Alcoholic Fatty Liver Disease: Investigating the Impact of Bariatric Care and the Role of Immune Function
… a potential role for liver immune function and intestinal microbiota (IM). The objectives of this research were 1) to prospectively evaluate the impact of bariatric care on metabolic and liver histology parameters by studying two bariatric care interventions: the routinely prescribed …
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Metabolomic analysis of the interleukin-10-deficient mouse model of Crohn's disease
… of the bowel, arising from the dysregulation of intestinal mucosal immunity. The interleukin-10-deficient (IL10-/-) mouse develops intestinal inflammation with similar characteristics to Crohn’s disease, due to the loss of immune tolerance towards intestinal microbiota. Metabolomic analysis is …
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