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Showing 1 to 6 of 6 for “"Intestinal metabolism"”.
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The Comparison of Rat and Human Intestinal and Hepatic Glucuronidation of Enterolactone Derived from Flaxseed Lignans
… and highly variable due to extensive first-pass metabolism, especially glucuronidation, which results in the large amount of glucuronide metabolites but low levels of free EL in human plasma. Hepatocytes and enterocytes express UDP-glucuronosyltransferases (UGT), the enzymes responsible for the …
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Folate Metabolism in Normal and Tumour Bearing Mammals
The whole animal metabolism and physiological disposition of folate derivatives has been studied in normal and tumour bearing rodents. Within 48 h of administration of radioactive folate tissue radioactivity was incorporated largely into high molecular weight folate conjugates. The major derivative …
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Investigation of Gut-Derived Circulating Succinate in Metabolism and Liver Signaling
… (TCA) cycle is the epicenter of cellular aerobic metabolism and accounts for the majority of cellular ATP production. In addition to its use in anabolic and catabolic processes, TCA cycle intermediates may serve as signaling molecules. The TCA cycle intermediates succinate and α-ketoglutarate are …
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Non-Canonical Roles of Cytosolic Phosphoenolpyruvate Carboxykinase in Small Intestine Metabolism
… Though amino acid, fatty acid, and glucose metabolism of the small intestine have been well studied, no investigation has emphasized the role of intestinal PEPCK in these pathways. The aim of this work is to examine the roles of PEPCK in small intestine function and metabolism. A mouse model …
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Activation of proestrogens from hops by human intestinal bacteria: conversion of isoxanthohumol into the potent phytoestrogen 8-prenylnaringenin
… other phytoestrogens and related with variable intestinal bacterial metabolism, the goal of this work was to investigate whether intestinal bacteria also determine the final activity of hop phytoestrogens by combining batch incubations with SHIME, rat and human studies. Batch incubations learned …
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Intestinal cytoplasmic lipid droplets, associated proteins, and the regulation of dietary fat absorption
… multi step process of digestion, uptake, metabolism, and secretion or storage. When dietary fat is taken up by the absorptive cells of the small intestine, enterocytes, it can be secreted into circulation where it contributes to blood lipid levels or temporarily stored in cytoplasmic lipid …