Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 96 for “"Intestinal epithelium"”.
-
Inflammasomes in the Intestinal Epithelium
… inflammasomes are critical for controlling intestinal pathogens and regulating epithelial-mucosal homeostasis, little is known about how they function in this cellular compartment. Moreover, very few studies focus specifically on inflammasomes in human cells, and this has implications for …
-
The origin and properties of pro-oncogenic fields in the intestinal epithelium
Abstract: The intestinal epithelium is maintained by intestinal stem cells that replace each other stochastically over time. Stem cells that are excluded from the stem cell pool will differentiate into the absorptive or secretory cell lineages. However, intestinal cell-fate specification is not …
-
Identifying novel roles for basement membrane-associated proteins in the adult Drosophila intestinal epithelium
Maintenance of a healthy epithelium relies on the functionality of resident stem and progenitor cells, which must divide and differentiate in a way that precisely meets tissue requirements. To achieve this, cells integrate an array of information, including chemical, mechanical and adhesion-based …
-
Role of cytokine IL-15 in the homeostasis of the intestinal epithelium and inflammatory bowel diseases
… Crohn’s disease, are characterized by increased intestinal permeability caused by intestinal mucosal barrier dysfunction, a critical factor in the pathogenesis of IBD. The immune system is the major effector of this tissue damage, through the action of multiple cell types as well as soluble …
-
Nuclear Rna Polymerase Activity in the Rat Intestinal Epithelium: A Comparison of Undifferentiated Crypt Cells and Differentiated Villus Epithelial Cells
Made available in DSpace on 2014-12-11T22:22:27Z (GMT). No. of bitstreams: 1 7514193.pdf: 4868084 bytes, checksum: febe65990dc399728e8f41180da2133d (MD5) Previous issue date: 1975
-
Interplay between Cannabinoids, SOCS3, and Autophagy Process in the Intestinal Epithelium with the Use of an Established in vitro Model System.
Autophagy is a catabolic process involved in homeostatic and regulated cellular protein recycling and degradation via the lysosomal degradation pathway. Emerging data associates Crohn's Disease (CD) with an impaired ATG16L1 autophagy gene. Increased activity in the endocannabinoid system and …
-
Characterization of the carbohydrate receptors of the <i>Clostridium difficile</i> enterotoxin
… after antibiotic therapy disrupts the normal intestinal microflora. Once established in the intestines, the organism causes disease by producing two toxins, designated toxin A and toxin B. Only toxin A is active on intestinal epithelium, thus toxin A is the cause of the initial tissue damage …
-
The Role of Cdx in Intestinal Development
… embryo and persist throughout adulthood in the intestinal epithelium, but their functions and mechanisms of action in this lineage are poorly understood, in part due to the peri-implantation lethality of Cdx2-/- mice. To circumvent this limitation, a conditional loss of function strategy was …
-
Tumor Suppressor APC and Musashi1: Double-Negative Feedback, Wnt Signaling and Colon Cancer
… role of APC in maintenance of homeostasis in the intestinal epithelium. I have identified a double-negative feedback loop between APC and a sequence specific RNA binding protein, Mushashi-1 (MSI1). I hypothesize that this feedback loop serves to maintain a critical balance and that disruption of …
-
Epithelial Retinoic Acid Receptor Beta Regulates Serum Amyloid A Expression and Vitamin A-Dependent Intestinal Immunity
… that is essential for the development of intestinal immunity. Vitamin A is absorbed and converted to its bioactive derivatives retinol and retinoic acid by the intestinal epithelium, yet little is known about how epithelial cells regulate vitamin A-dependent intestinal immunity. Here I …
-
Local effects of Linoorbitides and enterolactone On intestinal epithelial functions
… of LOBs and lignans at the level of the intestinal epithelium due to the potential lack of permeation of LOBs, and susceptibility of lignans to enterohepatic circulation. Our aim in this work is to evaluate the effects of the lignan enterolactone (ENL) and LOBs on intestinal epithelium …
-
Quantifying Intestinal Stem Cell Dynamics Using Microsatellite Sequencing
The intestinal epithelium is rapidly renewing throughout life. A population of stem cells exist within the intestinal crypt that drive rapid cell renewal and replace each other by a pattern of neutral drift. Perturbation of these dynamics through oncogenic mutation can predispose the epithelium to …
-
Interaction of Salmonella typhimurium and Listeria monocytogenes with the murine host
… that cause systemic disease must cross the intestinal barrier. Many of these pathogens, eg Salmonella typhimurium and Shigella flexneri, use M cells, found only within the follicle associated epithelium (FAE) that overlies Peyer’s patches and other lymphoid follicles, to enter the host. This …
-
Investigating the functional significance of the upregulation of Cyclin D2 and p21 following Apc loss in vivo
… this I have conditionally deleted c-Myc from the intestinal epithelium and examined the response of intestinal enterocytes following DNA damage. Remarkably, following DNA damage, c-Myc deficient enterocytes were unable to upregulate p53 and induce apoptosis, which was mechanistically due to an …
-
Notch activation and clone fate in intestinal homeostasis and inflammation
… and functions depending on the tissue. In the intestinal epithelium Notch signals are important for determining cell fate between the absorptive and secretory lineage and regulating the proliferation of intestinal stem cells (ISCs). As a result, Notch is also an important pathway during disease …
-
Transepithelial transport of nanoparticles targeted to the neonatal Fc receptor for oral delivery applications
… because of the barriers presented by the gastrointestinal tract. In particular, transport across the intestinal epithelium limits efficient oral delivery of NPs. The neonatal Fc receptor (FcRn) mediates IgG antibody transport across epithelial barriers. It was discovered as the receptor in the …
-
A Chemically Induced Colitis Screen Reveals the Necessity for Membrane Traffic in Intestinal Homeostasis
… membrane of enterocytes and functions in the intestinal epithelium to protect against colitis. SMCR8, along with C9ORF72 and WDR41, is a member of a tripartite complex that functions as a guanine exchange factor. SMCR8 localizes to the lysosome, and its absence results in perturbations to …
-
EFFECTOR T CELL HOMING TO THE SMALL INTESTINAL MUCOSA
The intestinal mucosa, including the intestinal epithelium and underlying lamina propria (LP), contains a large number of effector/memory T cells that are thought to play a central role in the generation and maintenance of mucosal immune responses and in maintaining mucosal integrity. The work in …
-
Investigating how Notch, and JAK/STAT Signaling Synergistically Regulate Intestinal Stem Cell Homeostasis Using Engineered Optogenetic Alleles
… elucidated, particularly as it relates to the intestinal epithelium. I utilize the Drosophila melanogaster midgut as a model system to study stem cell dynamics and more specifically, how Notch and JAK/STAT signaling cooperatively regulate intestinal stem cell turnover. In order to accomplish …
-
Genetic regulation of cell extrusion in caenorhabditis elegans
… squeezed out from a layer of cells, such as an epithelium. Cell extrusion is also an evolutionarily conserved form of cell elimination and has been observed in organisms ranging from Drosophila to mammals. It is the primary method of cell elimination in mammalian epithelial tissues, such as the …
Page 1 of 5