Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Intestinal dysfunction"”.
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The Role of Adipose-Specific Free Fatty Acid Receptor 2 in Obesity and Associated Metabolic Dysfunction
… insulin resistance and general metabolic dysfunction. Free Fatty Acid Receptor 2 (FFA2/GPR43) has emerged as a potential modulator of adipocyte function, inflammation, and metabolism. To investigate the role of FFA2 expressed in the adipose tissue, we generated adipose-specific FFA2 …
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OVEREXPRESSION OR REDUCED BIOAVAILABILITY OF VEGF DURING MOUSE POST-NATAL INTESTINAL DEVELOPMENT ALTERS THE PROLIFERATION OF INTESTINAL STEM CELL PROGENITOR CELLS
… VEGF affects the post-natal development of the intestinal epithelial by either overexpressing VEGF or by reducing the bioavailability of VEGF with the overexpression of soluble VEGF receptor (sFLT-1) within the gastrointestinal tract. After three weeks of VEGF overexpression, mutant mice …
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The role of organelle crosstalk in a Drosophila model of Parkinson’s disease
… in motor function. At present, mitochondrial dysfunction and the endoplasmic reticulum (ER) unfolded protein response (UPR) are perceived to be molecular features of PD. The UPR is an evolutionarily conserved adaptive cellular response to unfolded or misfolded proteins in the ER. Three …
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On Microvascular Inflammation and Intestinal Leakage in Radiation Enteropathy
Gastrointestinal tract damage is an insidious feature in patients undergoing radiotherapy. Microvascular inflammation, including leukocyte and platelet recruitment as well as epithelial barrier dysfunction, are considered to constitute key components in the pathophysiology of radiation-induced …
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Butyrate-Induced Expression of Proglucagon: Implications for Enteroendocrine Signaling and Intestinal Growth
While the gastrointestinal tract is primarily recognized for its digestive and absorptive capacity, it is also the largest endocrine organ in the body. There are a number of different types of endocrine cells in the gut which have the ability to mediate nutrient-gene interactions. Of interest for …
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Butyrate-induced expression of proglucagon: implications for enteroendocrine signaling and intestinal growth
While the gastrointestinal tract is primarily recognized for its digestive and absorptive capacity, it is also the largest endocrine organ in the body. There are a number of different types of endocrine cells in the gut which have the ability to mediate nutrient-gene interactions. Of interest for …
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Beyond the basal ganglia
… mainly focused on the role of the basal ganglia. Dysfunction of these brain nuclei likely underlies motor disturbances in HD, including the conspicuous, uncontrollable, dance-like movements (chorea). However, HD is frequently complicated by other important signs and symptoms that cannot, or not …
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Modulation of mechanosensitive gastro-oesophageal vagal afferents by novel targets.
… neuronal pathways and reflexes central to gastrointestinal disorders such as GORD, disordered food intake and functional dyspepsia. There are numerous candidates for modulation of vagal afferent signals from the gastrointestinal tract to the CNS, all of which may represent novel targets for …
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Technical and economic viability of value added product recovery in the corn dry grind ethanol process
… been linked with reduced risks of fatality and intestinal dysfunction in infant piglets. However, high costs associated with synthesis and purification restrict its commercial production. Distillers dried grains with solubles (DDGS) is a post-fermentation coproduct of corn dry grind ethanol …
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Evaluating the functional effects, morbidity, recurrence, survival and quality of life after curative treatment for rectal cancer
… receiving radiotherapy had even greater rectal dysfunction. This high rate of rectal dysfunction did not impact on the global quality of life. Patients with a permanent stoma had more restricted physical activity those without a stoma but there were no differences in mental functioning. There …
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Interactions Between Microbial, Neuronal, and Immune Cells in the Digestive System
… system (ENS). In concert with the commensal intestinal microbiota, the enteric immune and nervous systems communicate with one another, and this crosstalk was the focus of my thesis work. The studies as presented here are divided into two parts: The first part will focus on the influence of …