Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 54 for “"Intestinal barrier"”.
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Effects of GABA on inflammation and intestinal barrier disruption
<p> Gut dysbiosis and intestinal barrier disruption have been linked to multiple sclerosis (MS). Our previous works show that experimental autoimmune encephalomyelitis (EAE) induction modifies the gut's microbiota composition, reducing frequencies of gamma-aminobutyric acid (GABA)-producing …
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Role of Myosin Light Chain Kinase in Binge Ethanol and Burn Injury-Induced Intestinal Barrier Dysfunction
… that ethanol increases both pulmonary and gastrointestinal inflammation as well as susceptibility to infection in burn-injured mice; however, the mechanisms of these responses are not entirely known. Moreover, after burn injury, bacteria and their products leak out of the intestinal lumen and …
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INTERACTIVE EFFECT OF DIETARY FIBRE AND IMMUNE CHALLENGE ON THREONINE REQUIREMENT AND INTESTINAL BARRIER FUNCTION IN GROWING PIGS
… (Thr) may also play an important role in intestinal barrier function. Therefore, this thesis evaluated the independent and combined effects of high DF and immune challenge [Salmonella typhimurium and systemic E. coli lipopolysaccharide (LPS)] on the Thr requirement for PD and growth in …
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IMMUNOMODULATION AND INTESTINAL BARRIER PROTECTION ACTIVITIES OF A NOVEL SYNTHETIC GLUCOSE ANALOGUE IN INFLAMMATORY ANIMAL MODEL OF COLITIS AND ASTHMA.
The mucosal surfaces of the gastrointestinal and respiratory tracts are the main interfaces between the environment and the host. All two are protected by continuous epithelia that prevents the entry of microbes and integrity loss of these epithelia commonly predispose to infection. On the other …
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Effects of fructan source and degree of polymerization on intestinal barrier function and histomorphology characteristics in obese C57BL/6 mice
Obesity is linked to increased intestinal permeability that may contribute to low grade inflammation. Fructan prebiotics have been demonstrated to increase intestinal resistance and decrease systemic inflammation. The objective of this study was to test the effects of prebiotics on intestinal …
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¿CHIOS MASTIC GUM FROM PISTACIA LENTISCUS AS A MODULATOR OF INFLAMMATION AND INTESTINAL BARRIER FUNCTION: AN IN VITRO AND CLINICAL INVESTIGATION.¿
… by dysregulated inflammation and impaired intestinal barrier function. Although effective, current therapies present limitations, highlighting the need for complementary approaches. Chios Mastic Gum (CMG), a resin from Pistacia lentiscus, has shown anti-inflammatory and barrier-protective …
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Follow your gut: Does AKR1D1 impact gastrointestinal health?
… species in the intestine, disrupt cytoprotective intestinal bile acid signalling and drive gut dysbiosis, impairing intestinal barrier function and inducing hepatic inflammation. We have previously shown that expression of the bile acid synthesis enzyme 5β-reductase (AKR1D1) is decreased in …
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Interaction of Salmonella typhimurium and Listeria monocytogenes with the murine host
… that cause systemic disease must cross the intestinal barrier. Many of these pathogens, eg Salmonella typhimurium and Shigella flexneri, use M cells, found only within the follicle associated epithelium (FAE) that overlies Peyer’s patches and other lymphoid follicles, to enter the host. This …
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How Listeria monocytogenes crosses host cell barriers
… people. Listeria is able to cross several host barriers to cause severe disease, including the intestinal barrier, the blood-brain barrier, and the placental barrier. This is mediated by a diverse range of bacterial factors. In this review, I outline the key host barriers encountered by Listeria …
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The Role of MICRORNAs on Systemic and Central Nervous System- Inflammation in Aged Mice
… important risk factors for infection and sepsis. Intestinal barrier impairment occurs with aging and after brain injuries, including stroke. Both aging and stroke increase the risk of infection and sepsis and are a common cause of death in stroke patients. There has been a paucity of research …
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Adapt, Survive or Die - Metabolic Imbalances and the Enteric Nervous System
… Obese and T2D patients have high rates of gastrointestinal (GI) symptoms. The GI tract comprises the body’s largest surface to the outside environment; it performs diverse and complex roles in an ever changing external environment. It has evolved into a fine tuned sensory organ, with a complex …
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DIETARY BIOACTIVES IN THE MODULATION OF METABOLIC, FUNCTIONAL AND AGING BIOMARKERS
… health, including cardiometabolic regulation, intestinal function, and healthy aging. In particular, dietary (poly)phenols and xanthines have gained attention for their potential benefits on several metabolic and functional biomarkers. However, the mechanisms are not completely understood and …
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Giardia Cathepsins and Their Role in Intestinal Disease
… including humans, closely associates with intestinal epithelial cells. The pathophysiology of giardiasis includes intestinal barrier dysfunction and cytoskeletal injury; however, the mechanisms or parasitic factors involved remain unclear. The Giardia genome contains genes for …
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ESTABLISHING IN VITRO INTESTINAL EPITHELIAL CELL MODELS IN TRANSLATIONAL ANIMAL NUTRITION
… are reported to beneficially affect the host intestinal immunity. However so far, the biological pathways modulated by these nutrients in intestinal inflammation at the level of intestinal epithelial layer (IEL) remains elusive. To bridge this knowledge gap, the aim of our present study was …
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The gut microbiome: A key regulator of mucosal tolerance, barrier function, and vaccine response
In multicellular organisms, the gastrointestinal tract serves as the largest interface between the internal body and the external environment. In mammals, the gastrointestinal (GI) tract intestine is home to a diverse and dynamic microbial community, continuously exposing the mucosal epithelium to …
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Epithelial Cell Autophagy in Antibacterial Defense of the Small Intestine
… resident bacteria opportunistically invade the intestinal barrier, leading to pathologies such as inflammatory bowel disease (IBD), and bacteremia. As a result, epithelial cell innate immune responses play an essential role in preventing bacterial invasion of host tissues and maintaining a …
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Microbiota-host interactions and infection dynamics in critical illness.
… impaired host defense. We recently reported that intestinal dysbiosis in critically ill patients is associated with expansion of hypofunctional immature neutrophils, resulting in a significant reduction in infection-free survival. To further establish the causal impact of Enterobacteriaceae …
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Development of in vitro infant intestinal models to assess responses to infant formulae
Early postnatal nutrition and intestinal barrier maturation are intimately linked, with the neonatal gut characterized by higher permeability than in adults. The aim of this thesis was to develop and validate in vitro models that mimic the infant intestinal barrier. Once developed, these models …
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