Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 8 of 8 for “"Intestinal Stem Cells (ISCs)"”.
-
Integrity of the Barrier Epithelium in Drosophila Gut is Mediated by Factors That Regulate Intestinal Stem Cell Activity
<p>My thesis work on the Drosophila intestinal epithelium (IE) involved characterizing the mitochondrial unfolded protein response (UPRmt), validating proliferation specific regulatory genes, and proposing gut barrier function–specific genes as regulators of commensal bacteria density. The results …
-
The Regulation of Dna Methylation In Mammalian Development and Cancer
… with various human diseases. For example, cancer cells usually show global hypomethylation and regional hypermenthylation, which have been implicated in genomic instability and tumor suppressor silencing, respectively. Although great progress has been made in elucidating the biological functions …
-
Role of The Immune System In The Modulation of The Mmr-Deficient Intestinal Stem Cell Niche
… Repair (MMR) is a crucial DNA repair system to maintain genomic integrity in cells that is integrated by specific genes including <em>MLH1</em>, <em>MSH2</em>, <em>MSH6</em>, and <em>PMS2. </em>These genes play a critical role in repairing errors that occur in base pairing by stabilizing …
-
The Hippo Signaling Pathway in Organ Size Control and Regeneraton
… other two sites. The recent identification of intestinal stem cells (ISCs) has made the Drosophila adult midgut an excellent model to study adult stem cell biology. Multiple signaling pathways have been implicated in the regulation of ISC proliferation, self-renewal and differentiation. I …
-
Dissecting the Mechanisms and the Nutritional Requirements of the Expansion of Normal and Tumorigenic Intestinal Stem Cell Lineages in Drosophila melanogaster
… by injury and senescence. To replenish lost cells, adult tissue must contain a cellular reserve to maintain homeostasis. For example, adult stem cells exhibit two unique properties, self-renewal and potency, that make them well suited for this role. Tight regulatory control of stem cell …
-
Notch activation and clone fate in intestinal homeostasis and inflammation
… and functions depending on the tissue. In the intestinal epithelium Notch signals are important for determining cell fate between the absorptive and secretory lineage and regulating the proliferation of intestinal stem cells (ISCs). As a result, Notch is also an important pathway during disease …
-
Dysregulation of Noncanonical NF-κB Signaling in Gastrointestinal Diseases
… coordinated by a diverse interplay of immune cells detecting assaults from pathogens via recognition of pathogen associated molecular patterns (PAMPs) to mount an immune response, as well as detecting damage associated molecular patterns (DAMP) to indicate an area of damage and signal tissue …
-
Impaired ketogenesis is implicated in intestinal stem cell function and epithelial regeneration in ulcerative colitis
… to mucosal healing in Ulcerative Colitis (UC). Intestinal stem cells (ISCs) drive this response, proliferating and differentiating from the base of the crypt to regenerate the entire epithelium. ISCs therefore exist in a highly active state and resultantly are vulnerable to changes in energy …